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UBERON:0002106

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Name:spleen
Definition:"Organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system.[1] In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron.[2] It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells." [Wikipedia:Spleen]
Xrefs:
links:

AAO:0010395
BTO:0001281
EFO:0000869
EMAPA:18767
EV:0100055
FMA:7196
GAID:1289
galen:Spleen
[1]
MA:0000141
MAT:0000085
MESH:A.15.382.520.604.713
MIAA:0000085
ncithesaurus:Spleen
OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA
SCTID:181279003
TAO:0000436
VHOG:0000120
XAO:0000328

ZFA:0000436
Comments:This class was created automatically from a combination of ontologies
Alt_id: UBERON:FMA_7196-MA_0000141-MIAA_0000085-XAO_0000328-ZFA_0000436
Subset: organ_slim
uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:UBERON:0000077(mixed endoderm/mesoderm-derived structure),UBERON:0002075(viscus),UBERON:0004177(hemopoietic organ),UBERON:0005057(immune organ),UBERON:0005172(abdomen element)
develops_from:UBERON:0003104(mesenchyme),UBERON:0006293(spleen primordium)
part_of:UBERON:0000916(abdomen),UBERON:0001007(digestive system),UBERON:0002323(body cavity),UBERON:0002390(hematopoietic system),UBERON:0002405(immune system)



Children

is a:FF:10424-106D1 (splenic lymphoma with villous lymphocytes cell line:SLVL)
derives from:FF:0010025 (human spleen - adult sample),FF:0010044 (human spleen - fetal sample),FF:0011306 (mouse spleen- adult sample),FF:0011360 (mouse spleen- embryo E16 sample),FF:0011417 (mouse spleen- neonate N10 sample),FF:0011430 (mouse spleen- neonate N20 sample),FF:0011491 (mouse spleen- neonate N25 sample),FF:0011517 (mouse spleen-, embryo E18 sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology


Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002106 (spleen), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data