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Coexpression cluster:C784

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Full id: C784_Endothelial_Lymphatic_Renal_placenta_Hepatic_chronic_acute



Phase1 CAGE Peaks

Hg19::chr10:59999608..59999621,-p@chr10:59999608..59999621
-
Hg19::chr10:94590857..94590871,+p4@EXOC6
Hg19::chr10:94590876..94590889,+p6@EXOC6
Hg19::chr10:94590895..94590905,+p8@EXOC6
Hg19::chr10:94590910..94590942,+p3@EXOC6
Hg19::chr10:94590950..94590955,+p13@EXOC6
Hg19::chr10:94590997..94591006,+p11@EXOC6
Hg19::chr10:94591023..94591034,+p7@EXOC6
Hg19::chr12:96841308..96841312,+p@chr12:96841308..96841312
+
Hg19::chr1:78510648..78510661,+p7@GIPC2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0000145exocyst0.0153556442645342
GO:0006904vesicle docking during exocytosis0.0153556442645342
GO:0048278vesicle docking0.0153556442645342
GO:0022406membrane docking0.0153556442645342
GO:0044448cell cortex part0.0153556442645342
GO:0005938cell cortex0.0181941893586753
GO:0006887exocytosis0.0270288838613802



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Disease
Ontology termp-valuen
myeloid leukemia6.22e-1431
leukemia2.75e-1139
hematologic cancer1.54e-0851
immune system cancer1.54e-0851


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195862.992907456886080.006446587185075730.0280099479561561
ELF1#199772.980668571165280.002378202870469130.013471667277156
HEY1#2346272.8280777301740.003295391007019310.0170481147900777
JUN#3725810.01026335386916.45165515708383e-083.94961555070737e-06
SPI1#668875.743026455965913.41922598863134e-050.00067812484433473
TAF1#687272.34013240002170.01040839844348330.0386339241937289
TBP#690872.594739480967470.00558866901773640.0252716922213098



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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