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Coexpression cluster:C4382

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Full id: C4382_basal_hepatic_Eosinophils_Adipocyte_Preadipocyte_Neutrophils_Ewing



Phase1 CAGE Peaks

Hg19::chr4:15704615..15704626,+p5@BST1
Hg19::chr4:15704646..15704663,+p3@BST1
Hg19::chr4:15704679..15704733,+p1@BST1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
multi fate stem cell1.33e-23430
somatic stem cell3.79e-22436
stem cell1.44e-21444
myeloid leukocyte5.65e-2076
somatic cell9.90e-19591
CD14-positive, CD16-negative classical monocyte1.66e-1742
monopoietic cell2.69e-1663
monocyte2.69e-1663
monoblast2.69e-1663
promonocyte2.69e-1663
macrophage dendritic cell progenitor5.06e-1565
myeloid lineage restricted progenitor cell1.16e-1470
granulocyte monocyte progenitor cell1.47e-1471
classical monocyte2.13e-1445
non-terminally differentiated cell4.70e-13180
connective tissue cell1.87e-12365
mesenchymal cell2.07e-12358
mesodermal cell6.37e-12119
motile cell9.28e-11390
myeloid cell2.92e-09112
common myeloid progenitor2.92e-09112
contractile cell6.52e-0959
smooth muscle cell6.70e-0942
smooth muscle myoblast6.70e-0942
muscle precursor cell2.27e-0857
myoblast2.27e-0857
multi-potent skeletal muscle stem cell2.27e-0857
vascular associated smooth muscle cell2.62e-0832
muscle cell3.10e-0854
fibroblast7.09e-0875
electrically responsive cell1.69e-0760
electrically active cell1.69e-0760
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm5.62e-33216
musculoskeletal system1.08e-19167
cardiovascular system1.10e-19110
circulatory system4.89e-19113
hemolymphoid system6.77e-16112
vasculature2.11e-1579
vascular system2.11e-1579
hematopoietic system9.70e-14102
blood island9.70e-14102
splanchnic layer of lateral plate mesoderm1.27e-1384
vessel3.67e-1369
bone marrow8.94e-1380
connective tissue2.87e-12375
blood vessel2.12e-1160
epithelial tube open at both ends2.12e-1160
blood vasculature2.12e-1160
vascular cord2.12e-1160
mesoderm3.88e-11448
mesoderm-derived structure3.88e-11448
presumptive mesoderm3.88e-11448
bone element7.90e-1186
skeletal element1.10e-10101
skeletal system1.10e-10101
immune system3.19e-10115
artery1.67e-0942
arterial blood vessel1.67e-0942
arterial system1.67e-0942
epithelial tube9.64e-09118
muscle tissue6.90e-0863
musculature6.90e-0863
musculature of body6.90e-0863
multi-cellular organism8.28e-08659
systemic artery8.50e-0833
systemic arterial system8.50e-0833
skeletal muscle tissue1.31e-0761
striated muscle tissue1.31e-0761
myotome1.31e-0761
anatomical system4.62e-07625
anatomical group7.37e-07626


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.