Coexpression cluster:C846
From FANTOM5_SSTAR
Full id: C846_pancreas_leiomyoma_Smooth_tenocyte_Fibroblast_Adipocyte_Hepatocyte
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 3.40211704163772e-05 | 0.0215354008735668 | 2 | 167 | Protein processing in endoplasmic reticulum (KEGG):04141 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0019511 | peptidyl-proline hydroxylation | 0.00145708230307312 |
| GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 0.00145708230307312 |
| GO:0019471 | 4-hydroxyproline metabolic process | 0.00145708230307312 |
| GO:0018208 | peptidyl-proline modification | 0.00145708230307312 |
| GO:0031545 | peptidyl-proline 4-dioxygenase activity | 0.00291407882225392 |
| GO:0004656 | procollagen-proline 4-dioxygenase activity | 0.00291407882225392 |
| GO:0044432 | endoplasmic reticulum part | 0.00330733669435169 |
| GO:0019798 | procollagen-proline dioxygenase activity | 0.00437092521962316 |
| GO:0031543 | peptidyl-proline dioxygenase activity | 0.00453274461806331 |
| GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | 0.00476807149730774 |
| GO:0003756 | protein disulfide isomerase activity | 0.00476807149730774 |
| GO:0016862 | intramolecular oxidoreductase activity, interconverting keto- and enol-groups | 0.00485629763105131 |
| GO:0005783 | endoplasmic reticulum | 0.00541052206410783 |
| GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity | 0.0100987199993063 |
| GO:0022884 | macromolecule transmembrane transporter activity | 0.0100987199993063 |
| GO:0008320 | protein transmembrane transporter activity | 0.0101955228325995 |
| GO:0005793 | ER-Golgi intermediate compartment | 0.014238010123144 |
| GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | 0.014238010123144 |
| GO:0009306 | protein secretion | 0.017470575942967 |
| GO:0005788 | endoplasmic reticulum lumen | 0.018261464437518 |
| GO:0016860 | intramolecular oxidoreductase activity | 0.018261464437518 |
| GO:0065002 | intracellular protein transport across a membrane | 0.018261464437518 |
| GO:0048770 | pigment granule | 0.0201319783103799 |
| GO:0042470 | melanosome | 0.0201319783103799 |
| GO:0006575 | amino acid derivative metabolic process | 0.0209545000051523 |
| GO:0045454 | cell redox homeostasis | 0.0241718552410727 |
| GO:0018193 | peptidyl-amino acid modification | 0.0260734167618831 |
| GO:0046483 | heterocycle metabolic process | 0.0270087214901337 |
| GO:0009986 | cell surface | 0.0296802210019959 |
| GO:0008565 | protein transporter activity | 0.02985138195407 |
| GO:0005792 | microsome | 0.0303855457068317 |
| GO:0042598 | vesicular fraction | 0.0307047518939551 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 0.031180058507942 |
| GO:0044446 | intracellular organelle part | 0.0417957995859935 |
| GO:0044422 | organelle part | 0.0417957995859935 |
| GO:0032940 | secretion by cell | 0.0455416090038608 |
| GO:0015399 | primary active transmembrane transporter activity | 0.0455416090038608 |
| GO:0015405 | P-P-bond-hydrolysis-driven transmembrane transporter activity | 0.0455416090038608 |
| GO:0044444 | cytoplasmic part | 0.0455416090038608 |
| GO:0016853 | isomerase activity | 0.0455416090038608 |
| GO:0016023 | cytoplasmic membrane-bound vesicle | 0.0485945978872026 |
| GO:0031988 | membrane-bound vesicle | 0.0485945978872026 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| animal cell | 4.77e-26 | 679 |
| eukaryotic cell | 4.77e-26 | 679 |
| somatic cell | 4.05e-20 | 591 |
| non-terminally differentiated cell | 6.22e-20 | 180 |
| embryonic cell | 3.34e-16 | 248 |
| mesodermal cell | 9.33e-15 | 119 |
| native cell | 8.88e-13 | 722 |
| fibroblast | 1.38e-12 | 75 |
| muscle precursor cell | 8.21e-12 | 57 |
| myoblast | 8.21e-12 | 57 |
| multi-potent skeletal muscle stem cell | 8.21e-12 | 57 |
| contractile cell | 9.67e-12 | 59 |
| muscle cell | 7.34e-11 | 54 |
| smooth muscle cell | 1.59e-10 | 42 |
| smooth muscle myoblast | 1.59e-10 | 42 |
| electrically responsive cell | 5.56e-10 | 60 |
| electrically active cell | 5.56e-10 | 60 |
| somatic stem cell | 2.88e-09 | 436 |
| epithelial cell | 4.93e-09 | 254 |
| multi fate stem cell | 8.64e-09 | 430 |
| vascular associated smooth muscle cell | 9.38e-09 | 32 |
| stem cell | 2.70e-08 | 444 |
| Ontology term | p-value | n |
|---|---|---|
| ovarian cancer | 7.90e-08 | 14 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
