MCL coexpression mm9:1028

Phase1 CAGE Peaks

	Short description
Mm9::chr10:58071854..58071882,+	p@chr10:58071854..58071882 +
Mm9::chr1:127573438..127573451,+	p5@Gpr39
Mm9::chr1:127573708..127573719,+	p9@Gpr39
Mm9::chr1:127573773..127573786,+	p6@Gpr39
Mm9::chr1:137662814..137662817,+	p5@Phlda3
Mm9::chr2:50152414..50152430,+	p2@ENSMUST00000123699
Mm9::chr8:33119942..33119952,-	p4@Nrg1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005176	ErbB-2 class receptor binding	0.0258495539819157
GO:0046579	positive regulation of Ras protein signal transduction	0.0258495539819157
GO:0045213	neurotransmitter receptor metabolic process	0.0258495539819157
GO:0051057	positive regulation of small GTPase mediated signal transduction	0.0258495539819157
GO:0043624	cellular protein complex disassembly	0.0258495539819157
GO:0043241	protein complex disassembly	0.0258495539819157
GO:0032984	macromolecular complex disassembly	0.0258495539819157
GO:0007416	synaptogenesis	0.0269185018583432
GO:0048663	neuron fate commitment	0.0269185018583432
GO:0022411	cellular component disassembly	0.0269185018583432
GO:0007422	peripheral nervous system development	0.0269185018583432
GO:0043112	receptor metabolic process	0.0269185018583432
GO:0010001	glial cell differentiation	0.0377552695103153
GO:0042063	gliogenesis	0.0378231262427327
GO:0050808	synapse organization and biogenesis	0.037881510381851

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
muscle precursor cell	6.13e-16	6
contractile cell	6.13e-16	6
muscle cell	6.13e-16	6
myoblast	6.13e-16	6
mesodermal cell	1.52e-13	7
multi-potent skeletal muscle stem cell	2.37e-10	9
smooth muscle cell	4.24e-09	3
vascular associated smooth muscle cell	4.24e-09	3
aortic smooth muscle cell	4.24e-09	3
smooth muscle myoblast	4.24e-09	3
cardiocyte	1.81e-08	3
striated muscle cell	1.81e-08	3
cardiac muscle cell	1.81e-08	3
cardiac muscle myoblast	1.81e-08	3

Uber Anatomy

Ontology term	p-value	n
skeletal muscle tissue	2.37e-10	9
striated muscle tissue	2.37e-10	9
muscle tissue	2.37e-10	9
multilaminar epithelium	2.37e-10	9
epithelial vesicle	2.37e-10	9
musculature	2.37e-10	9
somite	2.37e-10	9
myotome	2.37e-10	9
presomitic mesoderm	2.37e-10	9
presumptive segmental plate	2.37e-10	9
dermomyotome	2.37e-10	9
trunk paraxial mesoderm	2.37e-10	9
musculature of body	3.11e-09	10
smooth muscle tissue	4.24e-09	3
blood vessel smooth muscle	4.24e-09	3
arterial system smooth muscle	4.24e-09	3
artery smooth muscle tissue	4.24e-09	3
aorta smooth muscle tissue	4.24e-09	3
compound organ	5.45e-09	43
cardiovascular system	5.65e-09	23
circulatory system	5.65e-09	23
dense mesenchyme tissue	2.56e-08	11
paraxial mesoderm	2.56e-08	11
presumptive paraxial mesoderm	2.56e-08	11
splanchnic layer of lateral plate mesoderm	2.86e-08	33
aorta	6.87e-07	4
artery	6.87e-07	4
systemic artery	6.87e-07	4
arterial blood vessel	6.87e-07	4
systemic arterial system	6.87e-07	4
aortic system	6.87e-07	4
arterial system	6.87e-07	4

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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