MCL coexpression mm9:1626

Phase1 CAGE Peaks

	Short description
Mm9::chr12:73862204..73862252,+	p2@Ppm1a
Mm9::chr12:73862254..73862303,+	p1@Ppm1a
Mm9::chr15:31460754..31460824,-	p1@March6
Mm9::chr16:13671951..13672011,+	p2@3110001I22Rik p2@Bfar
Mm9::chr5:89315834..89315850,+	p1@Slc4a4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008510	sodium:bicarbonate symporter activity	0.0149564455158056
GO:0015701	bicarbonate transport	0.0256241713817642
GO:0005452	inorganic anion exchanger activity	0.0256241713817642
GO:0015380	anion exchanger activity	0.0256241713817642
GO:0015106	bicarbonate transmembrane transporter activity	0.0256241713817642
GO:0015301	anion:anion antiporter activity	0.0256241713817642
GO:0015108	chloride transmembrane transporter activity	0.0256241713817642
GO:0015296	anion:cation symporter activity	0.0283892302834395
GO:0006885	regulation of pH	0.0283892302834395
GO:0015071	protein phosphatase type 2C activity	0.0283892302834395
GO:0008287	protein serine/threonine phosphatase complex	0.0285219372589867
GO:0015103	inorganic anion transmembrane transporter activity	0.0336041502350863
GO:0004722	protein serine/threonine phosphatase activity	0.0336041502350863
GO:0043169	cation binding	0.0336041502350863
GO:0015297	antiporter activity	0.0376142207968676
GO:0046872	metal ion binding	0.0376142207968676
GO:0043167	ion binding	0.0376485239032373
GO:0015294	solute:cation symporter activity	0.0430868884768256

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
anatomical conduit	1.56e-09	122
regional part of nervous system	1.71e-09	54
tube	3.34e-09	114
neural tube	2.42e-08	52
neural rod	2.42e-08	52
future spinal cord	2.42e-08	52
neural keel	2.42e-08	52
multi-tissue structure	2.75e-08	230
gray matter	1.35e-07	34
occipital lobe	5.40e-07	10
visual cortex	5.40e-07	10
neocortex	5.40e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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