MCL coexpression mm9:265
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005375 | copper ion transmembrane transporter activity | 0.00305968675443354 |
| GO:0006825 | copper ion transport | 0.00305968675443354 |
| GO:0004497 | monooxygenase activity | 0.011632809177397 |
| GO:0046915 | transition metal ion transmembrane transporter activity | 0.011632809177397 |
| GO:0015082 | di-, tri-valent inorganic cation transmembrane transporter activity | 0.016651154664395 |
| GO:0001681 | sialate O-acetylesterase activity | 0.0216281037515903 |
| GO:0004058 | aromatic-L-amino-acid decarboxylase activity | 0.0216281037515903 |
| GO:0015680 | intracellular copper ion transport | 0.0216281037515903 |
| GO:0004034 | aldose 1-epimerase activity | 0.0216281037515903 |
| GO:0005507 | copper ion binding | 0.0237324040824488 |
| GO:0000041 | transition metal ion transport | 0.0248674700475204 |
| GO:0043682 | copper-transporting ATPase activity | 0.0299334793539685 |
| GO:0004008 | copper-exporting ATPase activity | 0.0299334793539685 |
| GO:0050327 | testosterone 17-beta-dehydrogenase activity | 0.0416747881252043 |
| GO:0005783 | endoplasmic reticulum | 0.042507934462699 |
| GO:0004104 | cholinesterase activity | 0.045740498844209 |
| GO:0008126 | acetylesterase activity | 0.045740498844209 |
| GO:0004091 | carboxylesterase activity | 0.0480169632723307 |
| GO:0016491 | oxidoreductase activity | 0.0485779855711809 |
| GO:0004499 | flavin-containing monooxygenase activity | 0.0485779855711809 |
| GO:0030001 | metal ion transport | 0.0497145519814456 |
| GO:0006882 | cellular zinc ion homeostasis | 0.0497145519814456 |
| GO:0055069 | zinc ion homeostasis | 0.0497145519814456 |
| GO:0022890 | inorganic cation transmembrane transporter activity | 0.0497145519814456 |
| GO:0004745 | retinol dehydrogenase activity | 0.0497145519814456 |
| GO:0008508 | bile acid:sodium symporter activity | 0.0497145519814456 |
| GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives | 0.0497145519814456 |
| GO:0004303 | estradiol 17-beta-dehydrogenase activity | 0.0497145519814456 |
| GO:0015125 | bile acid transmembrane transporter activity | 0.0497145519814456 |
| GO:0006878 | cellular copper ion homeostasis | 0.0497145519814456 |
| GO:0005624 | membrane fraction | 0.0497145519814456 |
| GO:0008324 | cation transmembrane transporter activity | 0.0497145519814456 |
| GO:0006812 | cation transport | 0.0497145519814456 |
| GO:0055070 | copper ion homeostasis | 0.0497145519814456 |
| GO:0016853 | isomerase activity | 0.0497145519814456 |
| GO:0005792 | microsome | 0.0497145519814456 |
| GO:0042598 | vesicular fraction | 0.0497145519814456 |
| GO:0042423 | catecholamine biosynthetic process | 0.0497145519814456 |
| GO:0005641 | nuclear envelope lumen | 0.0497145519814456 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| intestinal epithelial cell | 1.65e-07 | 9 |
| epithelial cell of alimentary canal | 1.65e-07 | 9 |
| epithelial cell | 3.43e-07 | 25 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.00261508 |
| MA0004.1 | 0.275884 |
| MA0006.1 | 0.0229559 |
| MA0007.1 | 0.93006 |
| MA0009.1 | 0.961172 |
| MA0014.1 | 0.00733366 |
| MA0017.1 | 2.15732 |
| MA0019.1 | 0.650431 |
| MA0024.1 | 0.332319 |
| MA0025.1 | 7.3051 |
| MA0027.1 | 1.93116 |
| MA0028.1 | 0.0253985 |
| MA0029.1 | 0.315482 |
| MA0030.1 | 0.320542 |
| MA0031.1 | 0.293406 |
| MA0038.1 | 0.476304 |
| MA0040.1 | 0.377038 |
| MA0041.1 | 2.11028 |
| MA0042.1 | 0.391804 |
| MA0043.1 | 0.446565 |
| MA0046.1 | 5.92195 |
| MA0048.1 | 0.0268917 |
| MA0050.1 | 2.88866 |
| MA0051.1 | 0.948956 |
| MA0052.1 | 0.383564 |
| MA0055.1 | 0.130596 |
| MA0056.1 | 0 |
| MA0057.1 | 0.000751184 |
| MA0058.1 | 0.043314 |
| MA0059.1 | 0.0474385 |
| MA0060.1 | 0.998423 |
| MA0061.1 | 0.166845 |
| MA0063.1 | 0 |
| MA0066.1 | 0.150832 |
| MA0067.1 | 0.664516 |
| MA0068.1 | 0.126795 |
| MA0069.1 | 0.998292 |
| MA0070.1 | 0.37599 |
| MA0071.1 | 0.667184 |
| MA0072.1 | 0.966022 |
| MA0073.1 | 4.57484e-05 |
| MA0074.1 | 0.810061 |
| MA0076.1 | 0.0347575 |
| MA0077.1 | 0.351866 |
| MA0078.1 | 0.540438 |
| MA0081.1 | 1.19525 |
| MA0083.1 | 0.445897 |
| MA0084.1 | 0.971934 |
| MA0087.1 | 1.05539 |
| MA0088.1 | 0.023289 |
| MA0089.1 | 0 |
| MA0090.1 | 0.234247 |
| MA0091.1 | 0.0866349 |
| MA0092.1 | 0.234618 |
| MA0093.1 | 0.114799 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.123725 |
| MA0101.1 | 0.18882 |
| MA0103.1 | 0.0323969 |
| MA0105.1 | 0.385368 |
| MA0106.1 | 0.188607 |
| MA0107.1 | 0.0307115 |
| MA0108.2 | 0.245881 |
| MA0109.1 | 0 |
| MA0111.1 | 0.0718182 |
| MA0113.1 | 0.170658 |
| MA0114.1 | 1.97725 |
| MA0115.1 | 1.9906 |
| MA0116.1 | 0.24435 |
| MA0117.1 | 0.42191 |
| MA0119.1 | 0.0507723 |
| MA0122.1 | 0.438479 |
| MA0124.1 | 0.616327 |
| MA0125.1 | 0.55037 |
| MA0130.1 | 0 |
| MA0131.1 | 0.226654 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.477472 |
| MA0136.1 | 0.436338 |
| MA0139.1 | 0.0907756 |
| MA0140.1 | 0.781633 |
| MA0141.1 | 0.346747 |
| MA0142.1 | 0.282551 |
| MA0143.1 | 0.180984 |
| MA0144.1 | 0.0133016 |
| MA0145.1 | 0.0663158 |
| MA0146.1 | 0.0289936 |
| MA0147.1 | 0.0153902 |
| MA0148.1 | 1.034 |
| MA0149.1 | 0.194806 |
| MA0062.2 | 0.40577 |
| MA0035.2 | 1.87365 |
| MA0039.2 | 0.0512315 |
| MA0138.2 | 0.630162 |
| MA0002.2 | 0.202648 |
| MA0137.2 | 0.0372603 |
| MA0104.2 | 0.00724166 |
| MA0047.2 | 0.475155 |
| MA0112.2 | 0.0288521 |
| MA0065.2 | 0.899711 |
| MA0150.1 | 0.546781 |
| MA0151.1 | 0 |
| MA0152.1 | 0.475315 |
| MA0153.1 | 5.46159 |
| MA0154.1 | 0.38702 |
| MA0155.1 | 0.00350924 |
| MA0156.1 | 0.323742 |
| MA0157.1 | 0.259017 |
| MA0158.1 | 0 |
| MA0159.1 | 0.642998 |
| MA0160.1 | 0.300364 |
| MA0161.1 | 0 |
| MA0162.1 | 0.00377583 |
| MA0163.1 | 0.0173309 |
| MA0164.1 | 0.436868 |
| MA0080.2 | 2.20047 |
| MA0018.2 | 0.147322 |
| MA0099.2 | 0.619984 |
| MA0079.2 | 0.00315557 |
| MA0102.2 | 1.0223 |
| MA0258.1 | 0.0107784 |
| MA0259.1 | 0.064381 |
| MA0442.1 | 0 |
