Coexpression cluster:C1

Full id: C1_testis_epididymis_embryonic_medulla_pituitary_trachea_caudate

Phase1 CAGE Peaks

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Hg19::chr10:100206067..100206107,+	p@chr10:100206067..100206107 +
Hg19::chr10:100226702..100226710,-	p@chr10:100226702..100226710 -
Hg19::chr10:101119327..101119335,+	p6@CNNM1
Hg19::chr10:101380625..101380638,-	p10@SLC25A28
Hg19::chr10:101989381..101989400,+	p2@ENST00000444359
Hg19::chr10:102747052..102747060,-	p3@MRPL43
Hg19::chr10:102795886..102795905,+	p@chr10:102795886..102795905 +
Hg19::chr10:1034647..1034660,+	p3@GTPBP4
Hg19::chr10:1034666..1034675,+	p4@GTPBP4
Hg19::chr10:103526767..103526807,-	p@chr10:103526767..103526807 -
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
0.00106922262372736	0.0440739387471973	12	65	Glycolysis / Gluconeogenesis (KEGG):00010
2.92061264722708e-06	0.000616249268564915	27	153	RNA transport (KEGG):03013
0.000390216894033864	0.0205839411602863	15	84	mRNA surveillance pathway (KEGG):03015
0.000145699002463195	0.00922274685592022	8	25	Dorso-ventral axis formation (KEGG):04320
0.00111403320688018	0.0440739387471973	24	183	Huntington's disease (KEGG):05016
4.91128218607651e-05	0.00371190462835568	10	34	Fatty Acid Beta Oxidation (Wikipathways):WP143
5.27758951898912e-05	0.00371190462835568	12	48	Glycolysis and Gluconeogenesis (Wikipathways):WP534
0.000242850825015732	0.013974961112269	20	126	Metabolism of carbohydrates (Reactome):REACT_474
3.00752948800507e-05	0.00317294360984535	41	315	Cell Cycle, Mitotic (Reactome):REACT_152
1.29586911660761e-06	0.000410142575406309	55	421	Gene Expression (Reactome):REACT_71
1.11319657127999e-05	0.00169026403257765	27	164	Metabolism of RNA (Reactome):REACT_21257
1.33512166870272e-05	0.00169026403257765	30	194	HIV Infection (Reactome):REACT_6185
4.30717114439506e-05	0.00371190462835568	24	148	mRNA Processing (Reactome):REACT_1675
1.89389697870065e-07	0.000119883678751751	50	346	{CDC2,351} (Static Module):NA
0.00105635131603901	0.0440739387471973	5	13	{GAPDH,13} (Static Module):NA
0.000611272808984804	0.0297642836990293	10	45	{GLI1,45} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048232	male gamete generation	0
GO:0007283	spermatogenesis	0
GO:0019953	sexual reproduction	0
GO:0007276	gamete generation	0
GO:0044424	intracellular part	4.23362043533979e-55
GO:0005737	cytoplasm	8.80337911534492e-47
GO:0043231	intracellular membrane-bound organelle	7.22818580741109e-41
GO:0043227	membrane-bound organelle	7.22818580741109e-41
GO:0043226	organelle	7.42896095612408e-40
GO:0043229	intracellular organelle	1.24699012974532e-39
GO:0005622	intracellular	8.20095035813228e-36
GO:0005515	protein binding	1.06814844382708e-28
GO:0044464	cell part	2.62153724710214e-27
GO:0016043	cellular component organization and biogenesis	1.21155094158549e-26
GO:0044446	intracellular organelle part	6.16879531390781e-26
GO:0044422	organelle part	9.59192127375638e-26
GO:0005634	nucleus	2.3946535003449e-21
GO:0032502	developmental process	8.49644939498531e-21
GO:0048869	cellular developmental process	4.27852248264967e-20
GO:0030154	cell differentiation	4.27852248264967e-20
GO:0007049	cell cycle	3.31096670639216e-19
GO:0022402	cell cycle process	2.99432246394449e-18
GO:0015630	microtubule cytoskeleton	1.01416274579531e-17
GO:0022414	reproductive process	1.29878839843645e-17
GO:0044444	cytoplasmic part	2.81802193549612e-16
GO:0009566	fertilization	2.17558096786889e-15
GO:0007338	single fertilization	1.33305111357723e-14
GO:0044428	nuclear part	3.84864057284226e-14
GO:0005856	cytoskeleton	4.24671951231704e-14
GO:0006996	organelle organization and biogenesis	2.18671446478815e-13
GO:0006512	ubiquitin cycle	2.46052223929533e-13
GO:0031975	envelope	2.23974483906015e-12
GO:0065003	macromolecular complex assembly	2.23974483906015e-12
GO:0007275	multicellular organismal development	2.57667877031586e-12
GO:0022607	cellular component assembly	6.2616522894963e-12
GO:0031967	organelle envelope	7.83385552205938e-12
GO:0003712	transcription cofactor activity	1.04828017185295e-11
GO:0044238	primary metabolic process	1.9653889572235e-11
GO:0022403	cell cycle phase	1.98586831718415e-11
GO:0000279	M phase	1.98586831718415e-11
GO:0005874	microtubule	4.15258148329577e-11
GO:0007286	spermatid development	4.3753287231624e-11
GO:0043170	macromolecule metabolic process	5.12180048545753e-11
GO:0043687	post-translational protein modification	8.26874154405013e-11
GO:0048515	spermatid differentiation	1.7234330848237e-10
GO:0008134	transcription factor binding	4.03099116533809e-10
GO:0044237	cellular metabolic process	4.17118491447792e-10
GO:0005813	centrosome	5.27468294775141e-10
GO:0048523	negative regulation of cellular process	6.39102524336075e-10
GO:0006366	transcription from RNA polymerase II promoter	6.50892396363686e-10
GO:0003713	transcription coactivator activity	1.5719633889725e-09
GO:0019538	protein metabolic process	1.66226393616427e-09
GO:0006464	protein modification process	2.1974294532407e-09
GO:0043283	biopolymer metabolic process	2.79125750810284e-09
GO:0043233	organelle lumen	5.33958125384464e-09
GO:0031974	membrane-enclosed lumen	5.33958125384464e-09
GO:0048519	negative regulation of biological process	8.20547995263143e-09
GO:0005739	mitochondrion	1.13495079865507e-08
GO:0043412	biopolymer modification	1.17930471015682e-08
GO:0031090	organelle membrane	1.36926550100485e-08
GO:0019861	flagellum	1.62314113329351e-08
GO:0043228	non-membrane-bound organelle	2.53896452881295e-08
GO:0043232	intracellular non-membrane-bound organelle	2.53896452881295e-08
GO:0044260	cellular macromolecule metabolic process	3.26764377685333e-08
GO:0044430	cytoskeletal part	3.33835410089152e-08
GO:0044267	cellular protein metabolic process	4.25073456402383e-08
GO:0005815	microtubule organizing center	4.89791402128984e-08
GO:0051301	cell division	6.86066966796814e-08
GO:0007010	cytoskeleton organization and biogenesis	8.19169621870682e-08
GO:0031981	nuclear lumen	1.04625796940626e-07
GO:0031326	regulation of cellular biosynthetic process	1.2691290653275e-07
GO:0009889	regulation of biosynthetic process	3.2038922410246e-07
GO:0000074	regulation of progression through cell cycle	3.51726419957668e-07
GO:0005635	nuclear envelope	4.44771491888798e-07
GO:0044429	mitochondrial part	6.5012837200688e-07
GO:0006417	regulation of translation	6.5012837200688e-07
GO:0051726	regulation of cell cycle	6.5012837200688e-07
GO:0031966	mitochondrial membrane	1.07359190562511e-06
GO:0022618	protein-RNA complex assembly	1.08833733921072e-06
GO:0031965	nuclear membrane	1.13456199408882e-06
GO:0031968	organelle outer membrane	1.1579983733561e-06
GO:0065007	biological regulation	1.17931845352225e-06
GO:0005829	cytosol	1.57185955275723e-06
GO:0000278	mitotic cell cycle	1.79690409973825e-06
GO:0019867	outer membrane	1.85355236431311e-06
GO:0042995	cell projection	2.02879754036138e-06
GO:0000287	magnesium ion binding	2.15190994910107e-06
GO:0003006	reproductive developmental process	2.2221904154663e-06
GO:0005875	microtubule associated complex	2.39867161482347e-06
GO:0007017	microtubule-based process	2.43516959379415e-06
GO:0050789	regulation of biological process	2.70747252996494e-06
GO:0051246	regulation of protein metabolic process	3.35666986429494e-06
GO:0043234	protein complex	3.47345583594998e-06
GO:0035036	sperm-egg recognition	3.72872965248292e-06
GO:0007339	binding of sperm to zona pellucida	3.72872965248292e-06
GO:0051321	meiotic cell cycle	4.09633414141905e-06
GO:0007548	sex differentiation	4.20030083097572e-06
GO:0005741	mitochondrial outer membrane	4.97530938793883e-06
GO:0051641	cellular localization	5.60390005931758e-06
GO:0007067	mitosis	5.68108049632951e-06
GO:0001669	acrosome	6.43038159724458e-06
GO:0005740	mitochondrial envelope	7.2117853442135e-06
GO:0051649	establishment of cellular localization	7.83075655073484e-06
GO:0050794	regulation of cellular process	8.51868345012748e-06
GO:0000087	M phase of mitotic cell cycle	1.14987967100977e-05
GO:0009988	cell-cell recognition	1.34449957481713e-05
GO:0005929	cilium	1.34639188030504e-05
GO:0044248	cellular catabolic process	1.50750198546078e-05
GO:0051327	M phase of meiotic cell cycle	1.56550368598937e-05
GO:0007126	meiosis	1.56550368598937e-05
GO:0030317	sperm motility	1.56804953429622e-05
GO:0016281	eukaryotic translation initiation factor 4F complex	2.14608923884231e-05
GO:0006461	protein complex assembly	2.48930490703721e-05
GO:0004674	protein serine/threonine kinase activity	2.69786249972216e-05
GO:0045786	negative regulation of progression through cell cycle	2.72370245475017e-05
GO:0048468	cell development	2.82828640497305e-05
GO:0032501	multicellular organismal process	2.98814853835266e-05
GO:0033036	macromolecule localization	4.39564304750257e-05
GO:0044265	cellular macromolecule catabolic process	4.6667176166287e-05
GO:0045892	negative regulation of transcription, DNA-dependent	5.23872717173314e-05
GO:0009434	microtubule-based flagellum	5.27896920192129e-05
GO:0044453	nuclear membrane part	5.88309171383867e-05
GO:0006928	cell motility	6.55852680019278e-05
GO:0051674	localization of cell	6.55852680019278e-05
GO:0046661	male sex differentiation	8.23377862007882e-05
GO:0003702	RNA polymerase II transcription factor activity	8.33216526654277e-05
GO:0016563	transcription activator activity	8.33216526654277e-05
GO:0051236	establishment of RNA localization	8.38518896188244e-05
GO:0050657	nucleic acid transport	8.38518896188244e-05
GO:0050658	RNA transport	8.38518896188244e-05
GO:0003723	RNA binding	9.47907915717124e-05
GO:0006403	RNA localization	9.51099149658596e-05
GO:0045137	development of primary sexual characteristics	9.6595557588438e-05
GO:0006357	regulation of transcription from RNA polymerase II promoter	0.000113547908669402
GO:0048608	reproductive structure development	0.000133557171852753
GO:0008406	gonad development	0.000133557171852753
GO:0048522	positive regulation of cellular process	0.000163124435794625
GO:0009056	catabolic process	0.000165527409761533
GO:0008022	protein C-terminus binding	0.000167800220949046
GO:0031324	negative regulation of cellular metabolic process	0.00017190024832264
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0001834204292415
GO:0005643	nuclear pore	0.000186710938901944
GO:0016481	negative regulation of transcription	0.00023001516539158
GO:0005654	nucleoplasm	0.000253476050498718
GO:0009057	macromolecule catabolic process	0.000291083873710729
GO:0006323	DNA packaging	0.00032717754037739
GO:0050681	androgen receptor binding	0.000359236733684157
GO:0035258	steroid hormone receptor binding	0.000379854312618779
GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport	0.000390670860299252
GO:0008104	protein localization	0.000427551988982026
GO:0030054	cell junction	0.000478353774092236
GO:0051028	mRNA transport	0.000487833936375282
GO:0046907	intracellular transport	0.000513617699529088
GO:0012505	endomembrane system	0.000622225799150926
GO:0046930	pore complex	0.00070132465458382
GO:0009892	negative regulation of metabolic process	0.000729157932749919
GO:0016564	transcription repressor activity	0.000732051752075831
GO:0007268	synaptic transmission	0.000732051752075831
GO:0016874	ligase activity	0.000817998749046102
GO:0019222	regulation of metabolic process	0.000853221762221796
GO:0006413	translational initiation	0.000853221762221796
GO:0022613	ribonucleoprotein complex biogenesis and assembly	0.00087070453410655
GO:0046546	development of primary male sexual characteristics	0.00109151595973213
GO:0003796	lysozyme activity	0.00124034294765782
GO:0004690	cyclic nucleotide-dependent protein kinase activity	0.00124034294765782
GO:0019226	transmission of nerve impulse	0.00130949034522726
GO:0006446	regulation of translational initiation	0.00134163487565776
GO:0005794	Golgi apparatus	0.00134163487565776
GO:0008584	male gonad development	0.00134220930814912
GO:0005694	chromosome	0.00140666869899545
GO:0051276	chromosome organization and biogenesis	0.0014742600246462
GO:0048518	positive regulation of biological process	0.00184282455385361
GO:0006511	ubiquitin-dependent protein catabolic process	0.00200476397649829
GO:0006997	nuclear organization and biogenesis	0.00201280702187506
GO:0008037	cell recognition	0.00201280702187506
GO:0043632	modification-dependent macromolecule catabolic process	0.00211863057677857
GO:0019941	modification-dependent protein catabolic process	0.00211863057677857
GO:0051603	proteolysis involved in cellular protein catabolic process	0.00226183797447647
GO:0000079	regulation of cyclin-dependent protein kinase activity	0.00227135760977085
GO:0006913	nucleocytoplasmic transport	0.00244019951026983
GO:0044257	cellular protein catabolic process	0.00258708757425555
GO:0003724	RNA helicase activity	0.00260259708969564
GO:0045026	plasma membrane fusion	0.00261731312001755
GO:0004691	cAMP-dependent protein kinase activity	0.00268857207247839
GO:0003777	microtubule motor activity	0.00271017400661934
GO:0045184	establishment of protein localization	0.0027738787816839
GO:0051169	nuclear transport	0.00296265794813246
GO:0008186	RNA-dependent ATPase activity	0.00297410534289883
GO:0030518	steroid hormone receptor signaling pathway	0.00297410534289883
GO:0031323	regulation of cellular metabolic process	0.00308101847599022
GO:0005764	lysosome	0.00314380917549213
GO:0000323	lytic vacuole	0.00343493798197342
GO:0005773	vacuole	0.00347971870042587
GO:0019866	organelle inner membrane	0.00374603507834463
GO:0007289	spermatid nuclear differentiation	0.00398355078365317
GO:0051018	protein kinase A binding	0.00439544190114286
GO:0007340	acrosome reaction	0.00439544190114286
GO:0007127	meiosis I	0.00454115621138744
GO:0006352	transcription initiation	0.00461968909740027
GO:0044456	synapse part	0.00480115345903059
GO:0030522	intracellular receptor-mediated signaling pathway	0.00507752694009246
GO:0000082	G1/S transition of mitotic cell cycle	0.00541789310354173
GO:0035257	nuclear hormone receptor binding	0.00575462101597944
GO:0030286	dynein complex	0.00592626436153674
GO:0045211	postsynaptic membrane	0.0061625217556763
GO:0051427	hormone receptor binding	0.0065015146242297
GO:0051179	localization	0.00656411536532437
GO:0007342	fusion of sperm to egg plasma membrane	0.00670926396476537
GO:0044427	chromosomal part	0.00692531367686238
GO:0016773	phosphotransferase activity, alcohol group as acceptor	0.00814948087889976
GO:0051789	response to protein stimulus	0.00818858577382398
GO:0006986	response to unfolded protein	0.00818858577382398
GO:0006325	establishment and/or maintenance of chromatin architecture	0.00823165226487956
GO:0010468	regulation of gene expression	0.00866743529714997
GO:0006944	membrane fusion	0.00870036429518664
GO:0008494	translation activator activity	0.00870036429518664
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00893121545794581
GO:0005743	mitochondrial inner membrane	0.00903104403822781
GO:0032991	macromolecular complex	0.0091458230747264
GO:0030036	actin cytoskeleton organization and biogenesis	0.0091458230747264
GO:0015031	protein transport	0.00931663866039569
GO:0007281	germ cell development	0.0105817945184807
GO:0016998	cell wall catabolic process	0.0105817945184807
GO:0006605	protein targeting	0.011473819290081
GO:0000226	microtubule cytoskeleton organization and biogenesis	0.0116474553064716
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	0.0120116744333022
GO:0016568	chromatin modification	0.0121906026307035
GO:0048856	anatomical structure development	0.0122507069786343
GO:0007005	mitochondrion organization and biogenesis	0.0122507069786343
GO:0016879	ligase activity, forming carbon-nitrogen bonds	0.0123862719478295
GO:0006367	transcription initiation from RNA polymerase II promoter	0.012478328669234
GO:0010382	cell wall metabolic process	0.0130413485540829
GO:0007047	cell wall organization and biogenesis	0.0130413485540829
GO:0004672	protein kinase activity	0.0133265405158704
GO:0009893	positive regulation of metabolic process	0.0137753685684269
GO:0030163	protein catabolic process	0.0138411101755434
GO:0019899	enzyme binding	0.0144367879168693
GO:0000786	nucleosome	0.014886172999968
GO:0005819	spindle	0.0149253984930482
GO:0016406	carnitine O-acyltransferase activity	0.0152341839336227
GO:0004004	ATP-dependent RNA helicase activity	0.0158963058365522
GO:0030261	chromosome condensation	0.0158963058365522
GO:0007530	sex determination	0.0158963058365522
GO:0016070	RNA metabolic process	0.0158963058365522
GO:0000794	condensed nuclear chromosome	0.0166026579777547
GO:0016052	carbohydrate catabolic process	0.0166200422238663
GO:0031982	vesicle	0.0170113409539358
GO:0017156	calcium ion-dependent exocytosis	0.0174374225496825
GO:0007131	meiotic recombination	0.0192411820030951
GO:0045229	external encapsulating structure organization and biogenesis	0.0192411820030951
GO:0030029	actin filament-based process	0.0192411820030951
GO:0009386	translational attenuation	0.0192411820030951
GO:0001673	male germ cell nucleus	0.0192411820030951
GO:0007290	spermatid nuclear elongation	0.0192411820030951
GO:0043159	acrosomal matrix	0.0192411820030951
GO:0031058	positive regulation of histone modification	0.0192411820030951
GO:0030952	establishment and/or maintenance of cytoskeleton polarity	0.0192411820030951
GO:0030951	establishment and/or maintenance of microtubule cytoskeleton polarity	0.0192411820030951
GO:0035039	male pronucleus formation	0.0192411820030951
GO:0043285	biopolymer catabolic process	0.0193359219593648
GO:0031325	positive regulation of cellular metabolic process	0.0202906238770631
GO:0050790	regulation of catalytic activity	0.0205896793860806
GO:0004842	ubiquitin-protein ligase activity	0.0206763333225153
GO:0065002	intracellular protein transport across a membrane	0.0208289165206373
GO:0046903	secretion	0.0211487388047765
GO:0051130	positive regulation of cellular component organization and biogenesis	0.0220529559580094
GO:0005730	nucleolus	0.0222213184754228
GO:0000790	nuclear chromatin	0.0222897931014207
GO:0051271	negative regulation of cell motility	0.0222897931014207
GO:0003001	generation of a signal involved in cell-cell signaling	0.0225784925530474
GO:0017056	structural constituent of nuclear pore	0.0228361350534863
GO:0005385	zinc ion transmembrane transporter activity	0.0228361350534863
GO:0000339	RNA cap binding	0.0228361350534863
GO:0004221	ubiquitin thiolesterase activity	0.0230790691419633
GO:0008639	small protein conjugating enzyme activity	0.0235317934998236
GO:0006259	DNA metabolic process	0.0240562363646858
GO:0006468	protein amino acid phosphorylation	0.0240614445411257
GO:0030521	androgen receptor signaling pathway	0.0241346806458228
GO:0065004	protein-DNA complex assembly	0.0241346806458228
GO:0031410	cytoplasmic vesicle	0.0252237349305097
GO:0040013	negative regulation of locomotion	0.0261340206088292
GO:0008219	cell death	0.0263044481685982
GO:0016265	death	0.0263044481685982
GO:0016591	DNA-directed RNA polymerase II, holoenzyme	0.0263044481685982
GO:0007076	mitotic chromosome condensation	0.0272892219074818
GO:0042054	histone methyltransferase activity	0.0274880278494008
GO:0007050	cell cycle arrest	0.0277290803176653
GO:0016301	kinase activity	0.0277290803176653
GO:0019320	hexose catabolic process	0.0281056016069357
GO:0044275	cellular carbohydrate catabolic process	0.028686483274178
GO:0004843	ubiquitin-specific protease activity	0.029014541620793
GO:0031072	heat shock protein binding	0.0294978541574034
GO:0019318	hexose metabolic process	0.0295022294672826
GO:0046365	monosaccharide catabolic process	0.0301442936064128
GO:0006541	glutamine metabolic process	0.0301780757599759
GO:0000785	chromatin	0.0303606701718794
GO:0006302	double-strand break repair	0.0307593121997967
GO:0008276	protein methyltransferase activity	0.0309996272402259
GO:0019783	small conjugating protein-specific protease activity	0.0310082794333106
GO:0044451	nucleoplasm part	0.0342724079300031
GO:0046164	alcohol catabolic process	0.0348939581330135
GO:0006886	intracellular protein transport	0.0365817177134991
GO:0005996	monosaccharide metabolic process	0.0381513318350776
GO:0003714	transcription corepressor activity	0.0411753162128564
GO:0018024	histone-lysine N-methyltransferase activity	0.0413042601936914
GO:0016279	protein-lysine N-methyltransferase activity	0.0413042601936914
GO:0016278	lysine N-methyltransferase activity	0.0413042601936914
GO:0016023	cytoplasmic membrane-bound vesicle	0.0417915382432135
GO:0006007	glucose catabolic process	0.0427971227182524
GO:0044262	cellular carbohydrate metabolic process	0.0429963964966911
GO:0043549	regulation of kinase activity	0.0431453266227206
GO:0006350	transcription	0.0437422682764285
GO:0006006	glucose metabolic process	0.0444152384769106
GO:0065009	regulation of a molecular function	0.0444152384769106
GO:0004459	L-lactate dehydrogenase activity	0.0449279462798471
GO:0019642	anaerobic glycolysis	0.0449279462798471
GO:0051131	chaperone-mediated protein complex assembly	0.0451965411012424
GO:0000801	central element	0.0451965411012424
GO:0004075	biotin carboxylase activity	0.0451965411012424
GO:0005816	spindle pole body	0.0451965411012424
GO:0045578	negative regulation of B cell differentiation	0.0451965411012424
GO:0000150	recombinase activity	0.0451965411012424
GO:0031056	regulation of histone modification	0.0451965411012424
GO:0035092	sperm chromatin condensation	0.0451965411012424
GO:0004103	choline kinase activity	0.0451965411012424
GO:0006096	glycolysis	0.0466420515163397
GO:0019888	protein phosphatase regulator activity	0.0469820486288388
GO:0006915	apoptosis	0.0488611387708815
GO:0043167	ion binding	0.0494767037460143
GO:0031988	membrane-bound vesicle	0.0495081636407389
GO:0046872	metal ion binding	0.0497139626033944

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
testis	6.50e-34	8
male reproductive organ	4.86e-25	11
gonad	1.02e-13	21
indifferent external genitalia	1.02e-13	21
indifferent gonad	1.02e-13	21
gonad primordium	1.02e-13	21
external genitalia	3.77e-13	22
male organism	3.77e-13	22
male reproductive system	3.77e-13	22
body cavity	7.30e-07	46

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
MA0003.1	28.561
MA0004.1	5.66459
MA0006.1	8.83464
MA0007.1	2.21624
MA0009.1	0.170989
MA0014.1	2.12436
MA0017.1	1.59289
MA0019.1	0.00132776
MA0024.1	5.12024
MA0025.1	0.233524
MA0027.1	0.453731
MA0028.1	3.60588
MA0029.1	0.0484599
MA0030.1	0.0070629
MA0031.1	0.00364478
MA0038.1	1.79678
MA0040.1	0.010177
MA0041.1	0.00252347
MA0042.1	4.75785e-05
MA0043.1	3.51848
MA0046.1	9.52305e-06
MA0048.1	3.85471
MA0050.1	1.84524e-13
MA0051.1	1.30703e-10
MA0052.1	5.27042e-05
MA0055.1	0.00482536
MA0056.1	0
MA0057.1	2.79655e-15
MA0058.1	6.34114
MA0059.1	6.88183
MA0060.1	133.37
MA0061.1	0.0184383
MA0063.1	0
MA0066.1	8.47098
MA0067.1	0.730847
MA0068.1	1.12227e-09
MA0069.1	0.163109
MA0070.1	0.360676
MA0071.1	0.772478
MA0072.1	0.284085
MA0073.1	0
MA0074.1	1.06712
MA0076.1	2.24976
MA0077.1	2.37233
MA0078.1	18.1262
MA0081.1	0.000160173
MA0083.1	3.06694
MA0084.1	0.0829684
MA0087.1	0.0714334
MA0088.1	0.849295
MA0089.1	0
MA0090.1	0.407393
MA0091.1	1.36129
MA0092.1	0.0261859
MA0093.1	7.81309
MA0095.1	0
MA0098.1	0
MA0100.1	150.142
MA0101.1	0.0027718
MA0103.1	3.29645
MA0105.1	0.794933
MA0106.1	0.211293
MA0107.1	2.10031e-09
MA0108.2	0.105188
MA0109.1	0
MA0111.1	0.377214
MA0113.1	0.293344
MA0114.1	2.15191
MA0115.1	0.901065
MA0116.1	5.02416
MA0117.1	0.375298
MA0119.1	1.63821
MA0122.1	0.299944
MA0124.1	0.00558762
MA0125.1	0.0335724
MA0130.1	0
MA0131.1	9.2184
MA0132.1	0
MA0133.1	0
MA0135.1	0.0175828
MA0136.1	1.24536e-07
MA0139.1	3.38117
MA0140.1	1.03351
MA0141.1	6.62788
MA0142.1	0.089481
MA0143.1	4.59108
MA0144.1	0.000702263
MA0145.1	4.1716
MA0146.1	28.663
MA0147.1	25.3435
MA0148.1	8.3006e-06
MA0149.1	0
MA0062.2	2.8999
MA0035.2	0.093254
MA0039.2	1.01985
MA0138.2	0.814803
MA0002.2	0.0171171
MA0137.2	0.0119726
MA0104.2	31.0138
MA0047.2	7.94326e-05
MA0112.2	14.5521
MA0065.2	2.41247
MA0150.1	0.00286947
MA0151.1	0
MA0152.1	0.000219945
MA0153.1	0.00233413
MA0154.1	0.220457
MA0155.1	4.48117
MA0156.1	3.93435e-07
MA0157.1	0.00335181
MA0158.1	0
MA0159.1	2.71853
MA0160.1	10.4396
MA0161.1	0
MA0162.1	0.169863
MA0163.1	8.9876
MA0164.1	0.214356
MA0080.2	5.56562e-13
MA0018.2	25.3795
MA0099.2	5.12636e-13
MA0079.2	0
MA0102.2	0.0399404
MA0258.1	10.7641
MA0259.1	15.2786
MA0442.1	0

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ATF3#467	302	1.18475003612551	0.00152509240332078	0.00971273403929626
CHD2#1106	612	1.10557840979384	0.00466226979514862	0.0220078099496283
CTCFL#140690	352	1.21389433712172	0.000124646409602404	0.00166108796382104
E2F6#1876	1309	1.14695369416554	1.609320017654e-08	1.17125974441649e-06
ETS1#2113	700	1.18933507606386	8.45618701873474e-07	3.67675152393688e-05
GABPB1#2553	889	1.09730543666887	0.00142321915323813	0.0091730180909058
HSF1#3297	51	1.46329444638491	0.00522258238603163	0.0241998882743138
IRF1#3659	807	1.0763519296413	0.0125411944816704	0.0453622570641813
MXI1#4601	636	1.10645469016607	0.00370917362299545	0.0187068951135803
NFYA#4800	471	1.51562146517991	3.99479365901351e-19	9.5253939487149e-17
NFYB#4801	484	1.41665035534608	1.3137729585668e-14	2.25302354712246e-12
NRF1#4899	574	1.22401334316906	3.32293300892692e-07	1.65970253715599e-05
SETDB1#9869	188	1.32381504042368	8.37192025131484e-05	0.00125697955596186
SREBF1#6720	193	1.58437459692879	5.32531385277704e-10	5.13072374049983e-08
THAP1#55145	218	1.19428458320321	0.00454447762656829	0.0214809096556309
ZBTB33#10009	214	1.18341794558435	0.00708634014516332	0.0295516003202648
ZNF143#7702	470	1.10817533697994	0.0107921542899901	0.0398023095519556

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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FF samples	Score

FF samples	Score
testis, adult, pool2 CNhs12998	0.90
testis, adult, pool1 CNhs10632	0.76
Clontech Human Universal Reference Total RNA, pool1 CNhs10608	0.51
Adipocyte - breast, donor1 CNhs11051	0.00
Adipocyte - breast, donor2 CNhs11969	0.00
Adipocyte - omental, donor1 CNhs11054	0.00
Adipocyte - omental, donor2 CNhs12067	0.00
Adipocyte - omental, donor3 CNhs12068	0.00
Adipocyte - perirenal, donor1 CNhs12069	0.00
Adipocyte - subcutaneous, donor1 CNhs12494	0.00

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