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Coexpression cluster:C380

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Full id: C380_heart_left_throat_skeletal_mesothelioma_aorta_Mesothelial



Phase1 CAGE Peaks

Hg19::chr10:112462771..112462775,+p@chr10:112462771..112462775
+
Hg19::chr11:47367243..47367257,-p@chr11:47367243..47367257
-
Hg19::chr12:32974355..32974372,-p3@PKP2
Hg19::chr12:32974714..32974725,-p13@PKP2
Hg19::chr12:32974731..32974751,-p6@PKP2
Hg19::chr12:32974753..32974763,-p11@PKP2
Hg19::chr12:32974832..32974843,-p9@PKP2
Hg19::chr12:3373147..3373149,-p@chr12:3373147..3373149
-
Hg19::chr12:6041994..6041999,-p@chr12:6041994..6041999
-
Hg19::chr19:55661803..55661807,-p@chr19:55661803..55661807
-
Hg19::chr1:163112885..163112906,-p6@RGS5
Hg19::chr1:201328177..201328208,-p@chr1:201328177..201328208
-
Hg19::chr1:202550266..202550277,+p@chr1:202550266..202550277
+
Hg19::chr1:237214095..237214115,+p@chr1:237214095..237214115
+
Hg19::chr1:237226595..237226612,+p@chr1:237226595..237226612
+
Hg19::chr22:44535927..44535938,+p@chr22:44535927..44535938
+
Hg19::chr2:106039100..106039104,-p@chr2:106039100..106039104
-
Hg19::chr2:60666949..60666962,-p@chr2:60666949..60666962
-
Hg19::chr2:69810025..69810036,-p@chr2:69810025..69810036
-
Hg19::chr3:188604373..188604384,+p8@uc003fru.1
Hg19::chr4:190155067..190155109,+p@chr4:190155067..190155109
+
Hg19::chr4:53417758..53417768,-p@chr4:53417758..53417768
-
Hg19::chr5:123739302..123739319,-p@chr5:123739302..123739319
-
Hg19::chr5:142269334..142269337,-p@chr5:142269334..142269337
-
Hg19::chr5:79506498..79506503,+p@chr5:79506498..79506503
+
Hg19::chr6:128969727..128969733,+p@chr6:128969727..128969733
+
Hg19::chr7:113558943..113558969,-p2@PPP1R3A
Hg19::chr9:14031288..14031299,-p@chr9:14031288..14031299
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0004865type 1 serine/threonine specific protein phosphatase inhibitor activity0.0286925029942332
GO:0030057desmosome0.0286925029942332
GO:0004864protein phosphatase inhibitor activity0.0343924996183941
GO:0019212phosphatase inhibitor activity0.0343924996183941
GO:0008277regulation of G-protein coupled receptor protein signaling pathway0.0343924996183941
GO:0014704intercalated disc0.0343924996183941
GO:0005977glycogen metabolic process0.0343924996183941
GO:0006073glucan metabolic process0.0343924996183941
GO:0006112energy reserve metabolic process0.0350221767648703
GO:0019888protein phosphatase regulator activity0.0375536847932551
GO:0019208phosphatase regulator activity0.0375536847932551
GO:0044264cellular polysaccharide metabolic process0.0375536847932551
GO:0005976polysaccharide metabolic process0.0375536847932551
GO:0043296apical junction complex0.0375536847932551
GO:0009968negative regulation of signal transduction0.0375536847932551
GO:0016327apicolateral plasma membrane0.0375536847932551
GO:0015980energy derivation by oxidation of organic compounds0.0393701076521977



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
primary circulatory organ3.82e-5127
valve8.37e-393
cardiac mesenchyme8.37e-393
cardial valve8.37e-393
tunica intima8.37e-393
heart layer8.37e-393
endocardium8.37e-393
endocardial cushion8.37e-393
presumptive endocardium8.37e-393
pulmonary valve7.48e-301
semi-lunar valve7.48e-301
mitral valve1.33e-291
left cardiac atrium2.37e-291
compound organ1.45e-2068
heart1.92e-1924
primitive heart tube1.92e-1924
primary heart field1.92e-1924
anterior lateral plate mesoderm1.92e-1924
heart tube1.92e-1924
heart primordium1.92e-1924
cardiac mesoderm1.92e-1924
cardiogenic plate1.92e-1924
heart rudiment1.92e-1924
blood vessel layer2.67e-177
atrioventricular valve1.54e-152
cardiac atrium2.05e-152
future cardiac atrium2.05e-152
circulatory system1.36e-12112
neural crest-derived structure2.00e-1210
neural crest2.00e-1210
neural fold2.00e-1210
cardiac chamber9.90e-113
adult organism3.71e-09114
Disease
Ontology termp-valuen
heart disease1.13e-562
vascular disease4.20e-291
ischemia4.20e-291
extrinsic cardiomyopathy4.20e-291
myocardial ischemia4.20e-291
myocardial infarction4.20e-291
cardiovascular system disease5.61e-294


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.70285e-06
MA0004.10.108579
MA0006.10.0399016
MA0007.10.325854
MA0009.10.441048
MA0014.19.72827e-06
MA0017.10.198178
MA0019.10.574419
MA0024.10.354374
MA0025.11.37093
MA0027.11.98963
MA0028.10.0452766
MA0029.10.967833
MA0030.10.360703
MA0031.10.309631
MA0038.10.971238
MA0040.10.978317
MA0041.10.11856
MA0042.14.41134
MA0043.10.441316
MA0046.10.431829
MA0048.10.0100542
MA0050.10.102063
MA0051.10.165625
MA0052.12.62846
MA0055.10.000296687
MA0056.10
MA0057.10.079803
MA0058.10.0636171
MA0059.10.0630872
MA0060.10.0570653
MA0061.10.00791773
MA0063.10
MA0066.10.503778
MA0067.10.724802
MA0068.11.3169
MA0069.10.428576
MA0070.10.419162
MA0071.10.872033
MA0072.11.06722
MA0073.10.0416043
MA0074.10.495413
MA0076.10.0703269
MA0077.10.408948
MA0078.10.655763
MA0081.10.226222
MA0083.10.447432
MA0084.10.901266
MA0087.11.06276
MA0088.10.0265055
MA0089.10
MA0090.10.264964
MA0091.13.7755
MA0092.10.303729
MA0093.10.158872
MA0095.10
MA0098.10
MA0100.10.17714
MA0101.10.0419777
MA0103.10.146349
MA0105.10.00657589
MA0106.10.568183
MA0107.10.0213588
MA0108.20.828157
MA0109.10
MA0111.10.282297
MA0113.10.206168
MA0114.10.224223
MA0115.10.654355
MA0116.10.452238
MA0117.10.473208
MA0119.10.0566716
MA0122.10.495633
MA0124.10.616574
MA0125.10.541304
MA0130.10
MA0131.10.245067
MA0132.10
MA0133.10
MA0135.10.466979
MA0136.10.172767
MA0139.10.00650158
MA0140.10.865299
MA0141.10.838759
MA0142.10.285297
MA0143.10.206288
MA0144.10.200729
MA0145.10.0121518
MA0146.10.00068579
MA0147.10.0229785
MA0148.10.77456
MA0149.10.137231
MA0062.20.00728391
MA0035.21.39214
MA0039.22.58737e-05
MA0138.20.232954
MA0002.20.738914
MA0137.20.403398
MA0104.20.0115959
MA0047.20.548812
MA0112.20.00239494
MA0065.20.0130548
MA0150.10.257536
MA0151.10
MA0152.10.881953
MA0153.10.526421
MA0154.10.0232443
MA0155.10.00860269
MA0156.10.0483557
MA0157.10.264816
MA0158.10
MA0159.10.245967
MA0160.10.408878
MA0161.10
MA0162.14.24945e-06
MA0163.10.000420838
MA0164.11.15572
MA0080.20.158961
MA0018.20.196028
MA0099.20.147056
MA0079.22.89298e-16
MA0102.20.936833
MA0258.10.0714019
MA0259.10.259637
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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