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MCL coexpression mm9:797

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Phase1 CAGE Peaks

 Short description
Mm9::chr11:79153143..79153195,+p1@Nf1
Mm9::chr15:99125642..99125710,+p1@Prpf40b
Mm9::chr16:90284545..90284593,-p2@Scaf4
Mm9::chr2:32986085..32986140,-p1@Garnl3
Mm9::chr3:94386470..94386495,-p1@Snx27
Mm9::chr5:23181745..23181756,-p5@Srpk2
Mm9::chr5:23181759..23181815,-p2@Srpk2
Mm9::chr5:54200871..54200922,+p1@Tbc1d19
Mm9::chr8:108020923..108020968,-p1@Zdhhc1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0046929negative regulation of neurotransmitter secretion0.0122811985351359
GO:0021897forebrain astrocyte development0.0122811985351359
GO:0021896forebrain astrocyte differentiation0.0122811985351359
GO:0051056regulation of small GTPase mediated signal transduction0.0122811985351359
GO:0022011myelination in the peripheral nervous system0.0122811985351359
GO:0048712negative regulation of astrocyte differentiation0.0122811985351359
GO:0032292ensheathment of axons in the peripheral nervous system0.0122811985351359
GO:0005096GTPase activator activity0.0122811985351359
GO:0014065phosphoinositide 3-kinase cascade0.0122811985351359
GO:0046580negative regulation of Ras protein signal transduction0.0122811985351359
GO:0001937negative regulation of endothelial cell proliferation0.0122811985351359
GO:0048715negative regulation of oligodendrocyte differentiation0.0122811985351359
GO:0035021negative regulation of Rac protein signal transduction0.0122811985351359
GO:0048485sympathetic nervous system development0.0122811985351359
GO:0001953negative regulation of cell-matrix adhesion0.0122811985351359
GO:0014002astrocyte development0.0122811985351359
GO:0014044Schwann cell development0.0122811985351359
GO:0048853forebrain morphogenesis0.0122811985351359
GO:0032320positive regulation of Ras GTPase activity0.0122811985351359
GO:0008380RNA splicing0.0122811985351359
GO:0043525positive regulation of neuron apoptosis0.0122811985351359
GO:0048710regulation of astrocyte differentiation0.0122811985351359
GO:0001938positive regulation of endothelial cell proliferation0.0122811985351359
GO:0051224negative regulation of protein transport0.0122811985351359
GO:0048713regulation of oligodendrocyte differentiation0.0122811985351359
GO:0046823negative regulation of nucleocytoplasmic transport0.0122811985351359
GO:0048854brain morphogenesis0.0122811985351359
GO:0042308negative regulation of protein import into nucleus0.0122811985351359
GO:0042992negative regulation of transcription factor import into nucleus0.0122811985351359
GO:0051932synaptic transmission, GABAergic0.0122811985351359
GO:0032228regulation of synaptic transmission, GABAergic0.0122811985351359
GO:0048745smooth muscle development0.0122811985351359
GO:0022408negative regulation of cell-cell adhesion0.0122811985351359
GO:0008047enzyme activator activity0.0129742049098401
GO:0048844artery morphogenesis0.0132127414522
GO:0043409negative regulation of MAPKKK cascade0.0132127414522
GO:0007243protein kinase cascade0.0132127414522
GO:0007242intracellular signaling cascade0.0132127414522
GO:0006397mRNA processing0.0132127414522
GO:0014014negative regulation of gliogenesis0.0132127414522
GO:0045686negative regulation of glial cell differentiation0.0132127414522
GO:0001936regulation of endothelial cell proliferation0.0132127414522
GO:0007406negative regulation of neuroblast proliferation0.0132127414522
GO:0035020regulation of Rac protein signal transduction0.0132127414522
GO:0045124regulation of bone resorption0.0132127414522
GO:0051058negative regulation of small GTPase mediated signal transduction0.0132127414522
GO:0016071mRNA metabolic process0.0139020802348034
GO:0048708astrocyte differentiation0.0139020802348034
GO:0048483autonomic nervous system development0.0139020802348034
GO:0001952regulation of cell-matrix adhesion0.0139020802348034
GO:0014037Schwann cell differentiation0.0139020802348034
GO:0021987cerebral cortex development0.0139430757270679
GO:0042990regulation of transcription factor import into nucleus0.0139430757270679
GO:0045671negative regulation of osteoclast differentiation0.0139430757270679
GO:0042991transcription factor import into nucleus0.0139430757270679
GO:0018345protein palmitoylation0.0139430757270679
GO:0001935endothelial cell proliferation0.0139430757270679
GO:0042306regulation of protein import into nucleus0.0139430757270679
GO:0045685regulation of glial cell differentiation0.0139430757270679
GO:0002762negative regulation of myeloid leukocyte differentiation0.0139430757270679
GO:0014013regulation of gliogenesis0.0139430757270679
GO:0022407regulation of cell-cell adhesion0.0139430757270679
GO:0033157regulation of intracellular protein transport0.0139430757270679
GO:0030325adrenal gland development0.0139430757270679
GO:0032386regulation of intracellular transport0.0139430757270679
GO:0030695GTPase regulator activity0.0139430757270679
GO:0021782glial cell development0.0148901900249385
GO:0048709oligodendrocyte differentiation0.0148901900249385
GO:0051223regulation of protein transport0.0159094881213838
GO:0048169regulation of long-term neuronal synaptic plasticity0.0159094881213838
GO:0009966regulation of signal transduction0.0164158545922221
GO:0007264small GTPase mediated signal transduction0.0164158545922221
GO:0046822regulation of nucleocytoplasmic transport0.0164158545922221
GO:0051048negative regulation of secretion0.0164158545922221
GO:0006396RNA processing0.0164482517415702
GO:0051349positive regulation of lyase activity0.0164482517415702
GO:0045762positive regulation of adenylate cyclase activity0.0164482517415702
GO:0007162negative regulation of cell adhesion0.0164482517415702
GO:0031281positive regulation of cyclase activity0.0164482517415702
GO:0021510spinal cord development0.0164482517415702
GO:0021543pallium development0.0170713839836996
GO:0030336negative regulation of cell migration0.0170713839836996
GO:0048168regulation of neuronal synaptic plasticity0.0170713839836996
GO:0045453bone resorption0.0172496299708533
GO:0045670regulation of osteoclast differentiation0.0172496299708533
GO:0016601Rac protein signal transduction0.0172496299708533
GO:0016409palmitoyltransferase activity0.0172496299708533
GO:0030199collagen fibril organization0.0172496299708533
GO:0016525negative regulation of angiogenesis0.0179887538148397
GO:0045761regulation of adenylate cyclase activity0.0179887538148397
GO:0043407negative regulation of MAP kinase activity0.018393557445004
GO:0031279regulation of cyclase activity0.018393557445004
GO:0048593camera-type eye morphogenesis0.018393557445004
GO:0051051negative regulation of transport0.018393557445004
GO:0043408regulation of MAPKKK cascade0.018393557445004
GO:0051339regulation of lyase activity0.018393557445004
GO:0051271negative regulation of cell motility0.018393557445004
GO:0002761regulation of myeloid leukocyte differentiation0.018393557445004
GO:0046928regulation of neurotransmitter secretion0.018393557445004
GO:0040013negative regulation of locomotion0.0190288725956882
GO:0045638negative regulation of myeloid cell differentiation0.0190288725956882
GO:0030316osteoclast differentiation0.0192652183901487
GO:0050768negative regulation of neurogenesis0.0192652183901487
GO:0050804regulation of synaptic transmission0.0192652183901487
GO:0051969regulation of transmission of nerve impulse0.0192652183901487
GO:0001666response to hypoxia0.019484014560574
GO:0001889liver development0.019484014560574
GO:0048167regulation of synaptic plasticity0.019484014560574
GO:0000245spliceosome assembly0.019484014560574
GO:0043543protein amino acid acylation0.0198629027162399
GO:0007632visual behavior0.0198629027162399
GO:0008542visual learning0.0198629027162399
GO:0007422peripheral nervous system development0.0202218303126749
GO:0021537telencephalon development0.0202218303126749
GO:0050803regulation of synapse structure and activity0.0202218303126749
GO:0007270nerve-nerve synaptic transmission0.0209168425513918
GO:0001894tissue homeostasis0.0215997851100231
GO:0007405neuroblast proliferation0.0218997821277769
GO:0031644regulation of neurological process0.0218997821277769
GO:0048871multicellular organismal homeostasis0.0218997821277769
GO:0042552myelination0.0223668092785619
GO:0001649osteoblast differentiation0.0223668092785619
GO:0007272ensheathment of neurons0.0234419050993873
GO:0046850regulation of bone remodeling0.0234419050993873
GO:0008366axon ensheathment0.0234419050993873
GO:0045765regulation of angiogenesis0.0240551482023171
GO:0032318regulation of Ras GTPase activity0.0262436823525306
GO:0043523regulation of neuron apoptosis0.0268247639975477
GO:0045637regulation of myeloid cell differentiation0.0273966653713882
GO:0006469negative regulation of protein kinase activity0.0277461663059406
GO:0033673negative regulation of kinase activity0.0277461663059406
GO:0001508regulation of action potential0.028297754960841
GO:0051402neuron apoptosis0.0284136106874411
GO:0051348negative regulation of transferase activity0.0284136106874411
GO:0010001glial cell differentiation0.0284136106874411
GO:0002573myeloid leukocyte differentiation0.0295521882743893
GO:0042063gliogenesis0.0295521882743893
GO:0000377RNA splicing, via transesterification reactions with bulged adenosine as nucleophile0.0295521882743893
GO:0000398nuclear mRNA splicing, via spliceosome0.0295521882743893
GO:0000375RNA splicing, via transesterification reactions0.0295521882743893
GO:0048592eye morphogenesis0.0307672006968334
GO:0006497protein amino acid lipidation0.0312575822387891
GO:0050767regulation of neurogenesis0.0313031448429776
GO:0030155regulation of cell adhesion0.0313031448429776
GO:0001656metanephros development0.0313031448429776
GO:0008017microtubule binding0.031776118320949
GO:0043086negative regulation of catalytic activity0.0320246520231212
GO:0042158lipoprotein biosynthetic process0.0320246520231212
GO:0035270endocrine system development0.0324829642923157
GO:0007612learning0.0329350187926033
GO:0007269neurotransmitter secretion0.0340448277463405
GO:0030334regulation of cell migration0.0342548629309296
GO:0051046regulation of secretion0.0342548629309296
GO:0015631tubulin binding0.0357518516228022
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messenger0.0357518516228022
GO:0006606protein import into nucleus0.0358861806290778
GO:0035023regulation of Rho protein signal transduction0.0358861806290778
GO:0030198extracellular matrix organization and biogenesis0.0358861806290778
GO:0051170nuclear import0.0358861806290778
GO:0042157lipoprotein metabolic process0.0358861806290778
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messenger0.0362849803491617
GO:0051270regulation of cell motility0.0366787207857105
GO:0043405regulation of MAP kinase activity0.0368414737651879
GO:0019933cAMP-mediated signaling0.0368414737651879
GO:0019935cyclic-nucleotide-mediated signaling0.03789398518955
GO:0007160cell-matrix adhesion0.03789398518955
GO:0040012regulation of locomotion0.03789398518955
GO:0045055regulated secretory pathway0.03789398518955
GO:0043087regulation of GTPase activity0.03789398518955
GO:0017038protein import0.03789398518955
GO:0021915neural tube development0.0382568214182381
GO:0031589cell-substrate adhesion0.0391960958687573
GO:0007611learning and/or memory0.0395468297299959
GO:0022618protein-RNA complex assembly0.0404671364940083
GO:0001822kidney development0.0417081668276912
GO:0009416response to light stimulus0.0417081668276912
GO:0048732gland development0.0420360376301079
GO:0043010camera-type eye development0.042360101196051
GO:0001655urogenital system development0.0441042001662615
GO:0042060wound healing0.0441042001662615
GO:0007266Rho protein signal transduction0.0444108602440817
GO:0051049regulation of transport0.0463548636800031
GO:0045596negative regulation of cell differentiation0.0466452747343961
GO:0003001generation of a signal involved in cell-cell signaling0.0474729333330186
GO:0001505regulation of neurotransmitter levels0.0477538060040931
GO:0009968negative regulation of signal transduction0.0485658988273496
GO:0030099myeloid cell differentiation0.0488549614305601
GO:0006913nucleocytoplasmic transport0.0488549614305601
GO:0009314response to radiation0.0488549614305601
GO:0001503ossification0.0488549614305601
GO:0051169nuclear transport0.0488549614305601
GO:0031214biomineral formation0.0491177119273748
GO:0007519skeletal muscle development0.049377626283681



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
nervous system1.21e-2575
central nervous system1.29e-2573
ectoderm-derived structure4.56e-2595
ectoderm4.56e-2595
presumptive ectoderm4.56e-2595
neurectoderm2.96e-2164
neural plate2.96e-2164
presumptive neural plate2.96e-2164
ecto-epithelium7.49e-2073
regional part of nervous system2.41e-1954
neural tube6.89e-1852
neural rod6.89e-1852
future spinal cord6.89e-1852
neural keel6.89e-1852
structure with developmental contribution from neural crest7.71e-1892
brain3.61e-1547
future brain3.61e-1547
pre-chordal neural plate7.51e-1549
regional part of brain1.59e-1446
gray matter1.23e-1334
anterior neural tube4.50e-1340
regional part of forebrain1.69e-1239
forebrain1.69e-1239
future forebrain1.69e-1239
brain grey matter7.72e-1129
regional part of telencephalon7.72e-1129
telencephalon7.72e-1129
multi-cellular organism1.49e-10333
anatomical conduit8.20e-08122
tube8.34e-08114
embryo1.10e-07320
cerebral cortex4.90e-0721
cerebral hemisphere4.90e-0721
pallium4.90e-0721


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.16.75707
MA0004.10.394951
MA0006.10.238555
MA0007.10.38073
MA0009.10.82278
MA0014.18.01481
MA0017.10.726051
MA0019.10.642876
MA0024.10.779446
MA0025.11.05446
MA0027.12.46647
MA0028.10.692501
MA0029.10.757957
MA0030.10.764448
MA0031.10.729293
MA0038.10.534262
MA0040.10.835181
MA0041.10.323687
MA0042.10.311486
MA0043.10.918718
MA0046.10.858391
MA0048.10.993388
MA0050.10.431976
MA0051.10.542972
MA0052.10.84317
MA0055.10.0882028
MA0056.10
MA0057.11.39929
MA0058.10.305206
MA0059.10.316585
MA0060.10.9744
MA0061.10.194456
MA0063.10
MA0066.10.523573
MA0067.11.16502
MA0068.10.563625
MA0069.10.843506
MA0070.10.833895
MA0071.10.431174
MA0072.10.825495
MA0073.12.26312
MA0074.10.488775
MA0076.10.279739
MA0077.10.804033
MA0078.10.575205
MA0081.10.338098
MA0083.10.917931
MA0084.11.49188
MA0087.10.87515
MA0088.12.09482
MA0089.10
MA0090.10.362551
MA0091.10.407455
MA0092.10.362847
MA0093.10.2553
MA0095.10
MA0098.10
MA0100.12.08657
MA0101.10.324888
MA0103.10.272167
MA0105.11.1849
MA0106.11.42499
MA0107.10.266586
MA0108.20.665343
MA0109.10
MA0111.10.375908
MA0113.10.555251
MA0114.10.561811
MA0115.10.921497
MA0116.10.670446
MA0117.10.88947
MA0119.10.325434
MA0122.10.909168
MA0124.11.11203
MA0125.11.03833
MA0130.10
MA0131.11.54167
MA0132.10
MA0133.10
MA0135.10.954884
MA0136.10.508047
MA0139.11.39725
MA0140.11.20128
MA0141.10.29014
MA0142.10.714976
MA0143.10.571221
MA0144.10.568165
MA0145.10.442138
MA0146.18.59685
MA0147.10.593505
MA0148.10.410398
MA0149.10.330018
MA0062.20.365726
MA0035.21.21101
MA0039.28.44217
MA0138.20.630612
MA0002.20.447007
MA0137.20.783415
MA0104.20.157347
MA0047.20.533516
MA0112.21.6539
MA0065.20.44341
MA0150.10.991233
MA0151.10
MA0152.10.53362
MA0153.10.971406
MA0154.10.982083
MA0155.10.490492
MA0156.10.278949
MA0157.10.683365
MA0158.10
MA0159.10.214506
MA0160.10.413266
MA0161.10
MA0162.16.14973
MA0163.15.27522
MA0164.10.508398
MA0080.20.267388
MA0018.20.51781
MA0099.20.624421
MA0079.29.47384
MA0102.21.5442
MA0258.11.61881
MA0259.10.571417
MA0442.10
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