Coexpression cluster:C2936

Full id: C2936_CD14_parotid_salivary_submaxillary_corpus_Mallassezderived_substantia

Phase1 CAGE Peaks

Hg19::chr9:115913230..115913266,+	p2@SLC31A2
Hg19::chr9:115913271..115913298,+	p1@SLC31A2
Hg19::chr9:115913314..115913325,+	p3@SLC31A2
Hg19::chr9:115915412..115915416,+	p@chr9:115915412..115915416 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
myeloid leukocyte	1.02e-29	72
defensive cell	4.76e-29	48
phagocyte	4.76e-29	48
macrophage dendritic cell progenitor	1.67e-27	61
monopoietic cell	1.08e-26	59
monocyte	1.08e-26	59
monoblast	1.08e-26	59
promonocyte	1.08e-26	59
classical monocyte	1.60e-26	42
CD14-positive, CD16-negative classical monocyte	1.60e-26	42
granulocyte monocyte progenitor cell	3.55e-26	67
myeloid lineage restricted progenitor cell	5.89e-23	66
stuff accumulating cell	9.69e-18	87
myeloid cell	1.09e-15	108
common myeloid progenitor	1.09e-15	108
leukocyte	1.05e-09	136
nongranular leukocyte	9.54e-07	115

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	2.91e-25	98
blood island	2.91e-25	98
hemolymphoid system	2.29e-24	108
bone marrow	5.94e-23	76
immune system	2.48e-20	93
adult organism	5.52e-19	114
bone element	1.03e-18	82
skeletal element	2.04e-18	90
skeletal system	8.87e-17	100
embryonic structure	2.82e-09	564
anatomical system	1.06e-08	624
musculoskeletal system	1.13e-08	167
germ layer	1.23e-08	560
germ layer / neural crest	1.23e-08	560
embryonic tissue	1.23e-08	560
presumptive structure	1.23e-08	560
germ layer / neural crest derived structure	1.23e-08	560
epiblast (generic)	1.23e-08	560
anatomical group	1.65e-08	625
organ	1.97e-08	503
neural tube	6.51e-08	56
neural rod	6.51e-08	56
future spinal cord	6.51e-08	56
neural keel	6.51e-08	56
developing anatomical structure	7.16e-08	581
regional part of nervous system	4.47e-07	53
regional part of brain	4.47e-07	53
multi-cellular organism	9.77e-07	656

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ATF3#467	3	16.8473808945066	0.000340998682365564	0.00346536551401938
CCNT2#905	3	4.75215118272197	0.0138620699668949	0.0487504032485616
CHD2#1106	3	7.75801712558764	0.00335152246453634	0.0173084930363305
CTCF#10664	4	5.36025637307503	0.00121114538164362	0.00820676133870618
CTCFL#140690	3	14.8098557692308	0.000499629176756334	0.00441163101042059
ETS1#2113	3	7.29657069165175	0.0040085737751139	0.0192165352290058
HMGN3#9324	3	6.13391079251294	0.00664069668332472	0.0283173167119774
MAX#4149	3	4.83941663175534	0.0131573713783684	0.0466475222141833
SIX5#147912	3	12.8150365165942	0.000766447113693038	0.00601766426905632
SMC3#9126	3	11.2836996336996	0.00111580236686805	0.00766111915017637
USF1#7391	3	4.77112445790597	0.0137046588718802	0.0483433265079303
USF2#7392	3	9.7441480388022	0.00171834184841007	0.0107275930603204
ZBTB33#10009	3	23.7485437724859	0.000122945190881838	0.00165659563804777
ZBTB7A#51341	3	5.51393198090692	0.00903835282108109	0.0342646386540668
ZNF143#7702	3	10.1256574141709	0.00153486161068818	0.00977197096797509

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.