MCL coexpression mm9:1555

Phase1 CAGE Peaks

	Short description
Mm9::chr11:119089775..119089818,-	p1@Tbc1d16
Mm9::chr18:33622192..33622198,-	p@chr18:33622192..33622198 -
Mm9::chr18:33623069..33623097,-	p1@D0H4S114
Mm9::chr18:33623104..33623127,-	p4@D0H4S114
Mm9::chr7:52410080..52410104,+	p@chr7:52410080..52410104 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.00657426176518929
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0151208020599354
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0173122226483318
GO:0007167	enzyme linked receptor protein signaling pathway	0.0435216128855531
GO:0009966	regulation of signal transduction	0.0435216128855531

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	3.02e-09	23
neuroblast (sensu Vertebrata)	3.02e-09	23
neuron	5.05e-09	33
neuronal stem cell	5.05e-09	33
neuroblast	5.05e-09	33
electrically signaling cell	5.05e-09	33
electrically responsive cell	9.64e-07	39
electrically active cell	9.64e-07	39

Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	1.68e-10	333
structure with developmental contribution from neural crest	1.59e-09	92
neurectoderm	2.27e-08	64
neural plate	2.27e-08	64
presumptive neural plate	2.27e-08	64
ecto-epithelium	4.04e-08	73
embryo	8.50e-08	320
central nervous system	1.51e-07	73
ectoderm-derived structure	2.25e-07	95
ectoderm	2.25e-07	95
presumptive ectoderm	2.25e-07	95

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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