Coexpression cluster:C107: Difference between revisions
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Latest revision as of 10:33, 17 September 2013
Full id: C107_Neutrophils_CD14_Eosinophils_Monocytederived_Whole_Peripheral_blood
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
0.000399284027715807 | 0.0140414883080059 | 3 | 137 | Natural killer cell mediated cytotoxicity (KEGG):04650 |
2.10806633184702e-05 | 0.00190629426865595 | 3 | 51 | Malaria (KEGG):05144 |
2.7961012221032e-05 | 0.00221241509198916 | 3 | 56 | Staphylococcus aureus infection (KEGG):05150 |
0.000827571050037749 | 0.0275711828775734 | 3 | 176 | Influenza A (KEGG):05164 |
0.000123480847932684 | 0.00601256744164529 | 3 | 92 | Rheumatoid arthritis (KEGG):05323 |
3.61744606966908e-05 | 0.00254427040233392 | 3 | 61 | Selenium Pathway (Wikipathways):WP15 |
0.00137025589297375 | 0.039488154037708 | 2 | 52 | Vitamin B12 Metabolism (Wikipathways):WP1533 |
0.000158098556145312 | 0.00667175906933219 | 3 | 100 | Senescence and Autophagy (Wikipathways):WP615 |
0.00126753776840728 | 0.039488154037708 | 2 | 50 | Type II interferon signaling (IFNG) (Wikipathways):WP619 |
0.000366113029826168 | 0.0136323263458803 | 3 | 133 | T Cell Receptor Signaling Pathway (Wikipathways):WP69 |
1.31693457438319e-05 | 0.00138936597597427 | 6 | 511 | Signaling in Immune system (Reactome):REACT_6900 |
0.00137241609609728 | 0.039488154037708 | 4 | 466 | Hemostasis (Reactome):REACT_604 |
0.00017682353653931 | 0.00699558116433646 | 6 | 816 | TGF beta receptor up reg. targets (Netpath):NetPath_7 |
6.13226721795312e-07 | 9.70431287241081e-05 | 8 | 728 | TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9 |
5.64966556451738e-07 | 9.70431287241081e-05 | 5 | 155 | IL-1 up reg. targets (Netpath):NetPath_13 |
8.17819163062055e-05 | 0.00431399608515234 | 5 | 433 | IL-2 up reg. targets (Netpath):NetPath_14 |
1.31367905060236e-05 | 0.00138936597597427 | 5 | 295 | IL-2 down reg. targets (Netpath):NetPath_14 |
7.62220659880978e-05 | 0.00431399608515234 | 4 | 217 | IL-4 up reg. targets (Netpath):NetPath_16 |
4.63242987303954e-10 | 2.93232810963403e-07 | 6 | 90 | IL-4 down reg. targets (Netpath):NetPath_16 |
2.44960860146816e-07 | 7.75301122364673e-05 | 5 | 131 | IL-5 up reg. targets (Netpath):NetPath_17 |
8.14764635786901e-05 | 0.00431399608515234 | 3 | 80 | IL-6 up reg. targets (Netpath):NetPath_18 |
0.00164389721031691 | 0.0452429101795916 | 2 | 57 | IL-7 up reg. targets (Netpath):NetPath_19 |
0.000143788099166343 | 0.00650127619802109 | 2 | 17 | {RARA,17} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0001816 | cytokine production | 2.2290398649873e-11 |
GO:0006952 | defense response | 5.433798875121e-06 |
GO:0009605 | response to external stimulus | 6.7497786026716e-06 |
GO:0006954 | inflammatory response | 1.96328965111205e-05 |
GO:0042035 | regulation of cytokine biosynthetic process | 2.0964285662949e-05 |
GO:0065007 | biological regulation | 2.0964285662949e-05 |
GO:0005515 | protein binding | 2.0964285662949e-05 |
GO:0042089 | cytokine biosynthetic process | 2.0964285662949e-05 |
GO:0042107 | cytokine metabolic process | 2.0964285662949e-05 |
GO:0042221 | response to chemical stimulus | 2.55364701945347e-05 |
GO:0009611 | response to wounding | 6.35925373718454e-05 |
GO:0002274 | myeloid leukocyte activation | 7.85130404390194e-05 |
GO:0045084 | positive regulation of interleukin-12 biosynthetic process | 9.83625055051188e-05 |
GO:0048519 | negative regulation of biological process | 0.000142006681156699 |
GO:0050789 | regulation of biological process | 0.000142006681156699 |
GO:0006955 | immune response | 0.000142006681156699 |
GO:0045075 | regulation of interleukin-12 biosynthetic process | 0.000142006681156699 |
GO:0042090 | interleukin-12 biosynthetic process | 0.000142006681156699 |
GO:0006950 | response to stress | 0.000153439360301109 |
GO:0042108 | positive regulation of cytokine biosynthetic process | 0.000170360441221724 |
GO:0042330 | taxis | 0.000173301283204169 |
GO:0006935 | chemotaxis | 0.000173301283204169 |
GO:0032615 | interleukin-12 production | 0.000277555723537233 |
GO:0031325 | positive regulation of cellular metabolic process | 0.000278623758926738 |
GO:0002376 | immune system process | 0.000278623758926738 |
GO:0045727 | positive regulation of translation | 0.000278623758926738 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.000278623758926738 |
GO:0045321 | leukocyte activation | 0.000324159245032858 |
GO:0007626 | locomotory behavior | 0.000324159245032858 |
GO:0006417 | regulation of translation | 0.000326708765467945 |
GO:0009893 | positive regulation of metabolic process | 0.000326708765467945 |
GO:0031328 | positive regulation of cellular biosynthetic process | 0.000338234990026411 |
GO:0031326 | regulation of cellular biosynthetic process | 0.000413274490095933 |
GO:0032501 | multicellular organismal process | 0.000414243486747844 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.000421937304622257 |
GO:0001775 | cell activation | 0.000458987569102588 |
GO:0009891 | positive regulation of biosynthetic process | 0.000465367139162871 |
GO:0009889 | regulation of biosynthetic process | 0.000492523719130039 |
GO:0048523 | negative regulation of cellular process | 0.000492523719130039 |
GO:0042088 | T-helper 1 type immune response | 0.000700069451730291 |
GO:0051247 | positive regulation of protein metabolic process | 0.000751520218800036 |
GO:0050794 | regulation of cellular process | 0.000814844471591072 |
GO:0045941 | positive regulation of transcription | 0.00118150492484849 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00132280558750138 |
GO:0007610 | behavior | 0.00138184988058552 |
GO:0048522 | positive regulation of cellular process | 0.00151586155017615 |
GO:0009620 | response to fungus | 0.00153817121316647 |
GO:0050663 | cytokine secretion | 0.00167262002127017 |
GO:0010468 | regulation of gene expression | 0.00169125801383065 |
GO:0031323 | regulation of cellular metabolic process | 0.00209283920943127 |
GO:0048518 | positive regulation of biological process | 0.00245247638102661 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 0.00255052842973593 |
GO:0045185 | maintenance of protein localization | 0.00258323322401245 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.00260130132644168 |
GO:0019222 | regulation of metabolic process | 0.00303547485230157 |
GO:0006351 | transcription, DNA-dependent | 0.00303547485230157 |
GO:0032774 | RNA biosynthetic process | 0.00303547485230157 |
GO:0048513 | organ development | 0.00317548114244536 |
GO:0051246 | regulation of protein metabolic process | 0.00418751893043749 |
GO:0045449 | regulation of transcription | 0.0046738062421673 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00523251555619257 |
GO:0001817 | regulation of cytokine production | 0.00544137798478529 |
GO:0051235 | maintenance of localization | 0.00544137798478529 |
GO:0006350 | transcription | 0.0057694572000471 |
GO:0006915 | apoptosis | 0.0057694572000471 |
GO:0012501 | programmed cell death | 0.0057694572000471 |
GO:0051707 | response to other organism | 0.0057694572000471 |
GO:0010467 | gene expression | 0.0057694572000471 |
GO:0008219 | cell death | 0.0057694572000471 |
GO:0016265 | death | 0.0057694572000471 |
GO:0045893 | positive regulation of transcription, DNA-dependent | 0.0057694572000471 |
GO:0033371 | T cell secretory granule organization and biogenesis | 0.0057694572000471 |
GO:0033377 | maintenance of protein localization in T cell secretory granule | 0.0057694572000471 |
GO:0033365 | protein localization in organelle | 0.0057694572000471 |
GO:0033370 | maintenance of protein localization in mast cell secretory granule | 0.0057694572000471 |
GO:0002335 | mature B cell differentiation | 0.0057694572000471 |
GO:0033367 | protein localization in mast cell secretory granule | 0.0057694572000471 |
GO:0033366 | protein localization in secretory granule | 0.0057694572000471 |
GO:0002312 | B cell activation during immune response | 0.0057694572000471 |
GO:0016046 | detection of fungus | 0.0057694572000471 |
GO:0033382 | maintenance of granzyme B localization in T cell secretory granule | 0.0057694572000471 |
GO:0033373 | maintenance of protease localization in mast cell secretory granule | 0.0057694572000471 |
GO:0033380 | granzyme B localization in T cell secretory granule | 0.0057694572000471 |
GO:0033379 | maintenance of protease localization in T cell secretory granule | 0.0057694572000471 |
GO:0032996 | Bcl3-Bcl10 complex | 0.0057694572000471 |
GO:0033364 | mast cell secretory granule organization and biogenesis | 0.0057694572000471 |
GO:0008383 | manganese superoxide dismutase activity | 0.0057694572000471 |
GO:0033368 | protease localization in mast cell secretory granule | 0.0057694572000471 |
GO:0002313 | mature B cell differentiation during immune response | 0.0057694572000471 |
GO:0019371 | cyclooxygenase pathway | 0.0057694572000471 |
GO:0033374 | protein localization in T cell secretory granule | 0.0057694572000471 |
GO:0033375 | protease localization in T cell secretory granule | 0.0057694572000471 |
GO:0002315 | marginal zone B cell differentiation | 0.0057694572000471 |
GO:0043066 | negative regulation of apoptosis | 0.00590418382699472 |
GO:0043069 | negative regulation of programmed cell death | 0.00606776012889687 |
GO:0009306 | protein secretion | 0.00689378387994926 |
GO:0032502 | developmental process | 0.00702996740489555 |
GO:0016070 | RNA metabolic process | 0.00795523672046586 |
GO:0030155 | regulation of cell adhesion | 0.00894330730733729 |
GO:0019932 | second-messenger-mediated signaling | 0.00894749628732592 |
GO:0002268 | follicular dendritic cell differentiation | 0.00971286054594151 |
GO:0033257 | Bcl3/NF-kappaB2 complex | 0.00971286054594151 |
GO:0042629 | mast cell granule | 0.00971286054594151 |
GO:0033363 | secretory granule organization and biogenesis | 0.00971286054594151 |
GO:0046696 | lipopolysaccharide receptor complex | 0.00971286054594151 |
GO:0033256 | I-kappaB/NF-kappaB complex | 0.00971286054594151 |
GO:0002266 | follicular dendritic cell activation | 0.00971286054594151 |
GO:0005153 | interleukin-8 receptor binding | 0.00971286054594151 |
GO:0001315 | age-dependent response to reactive oxygen species | 0.00971286054594151 |
GO:0045415 | negative regulation of interleukin-8 biosynthetic process | 0.00971286054594151 |
GO:0007165 | signal transduction | 0.00971286054594151 |
GO:0048731 | system development | 0.00982317753055583 |
GO:0009607 | response to biotic stimulus | 0.00982317753055583 |
GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.0101775419916928 |
GO:0002250 | adaptive immune response | 0.0101775419916928 |
GO:0051649 | establishment of cellular localization | 0.0103766203444414 |
GO:0051641 | cellular localization | 0.0114864701962215 |
GO:0007275 | multicellular organismal development | 0.0118899996931101 |
GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway | 0.0124682133320994 |
GO:0045082 | positive regulation of interleukin-10 biosynthetic process | 0.0124682133320994 |
GO:0004944 | C5a anaphylatoxin receptor activity | 0.0124682133320994 |
GO:0010225 | response to UV-C | 0.0124682133320994 |
GO:0001530 | lipopolysaccharide binding | 0.0124682133320994 |
GO:0004666 | prostaglandin-endoperoxide synthase activity | 0.0124682133320994 |
GO:0050860 | negative regulation of T cell receptor signaling pathway | 0.0124682133320994 |
GO:0042091 | interleukin-10 biosynthetic process | 0.0124682133320994 |
GO:0019730 | antimicrobial humoral response | 0.0124682133320994 |
GO:0045074 | regulation of interleukin-10 biosynthetic process | 0.0124682133320994 |
GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process | 0.0124682133320994 |
GO:0002521 | leukocyte differentiation | 0.0125621045497277 |
GO:0051704 | multi-organism process | 0.012643356332854 |
GO:0030674 | protein binding, bridging | 0.012643356332854 |
GO:0043405 | regulation of MAP kinase activity | 0.013095735842446 |
GO:0042742 | defense response to bacterium | 0.0135523882118116 |
GO:0008283 | cell proliferation | 0.0141965606161204 |
GO:0048869 | cellular developmental process | 0.0141965606161204 |
GO:0030154 | cell differentiation | 0.0141965606161204 |
GO:0007154 | cell communication | 0.0141965606161204 |
GO:0048468 | cell development | 0.0141965606161204 |
GO:0005087 | Ran guanyl-nucleotide exchange factor activity | 0.0141965606161204 |
GO:0002467 | germinal center formation | 0.0141965606161204 |
GO:0045091 | regulation of retroviral genome replication | 0.0141965606161204 |
GO:0019369 | arachidonic acid metabolic process | 0.0141965606161204 |
GO:0004942 | anaphylatoxin receptor activity | 0.0141965606161204 |
GO:0001892 | embryonic placenta development | 0.0141965606161204 |
GO:0004992 | platelet activating factor receptor activity | 0.0141965606161204 |
GO:0000303 | response to superoxide | 0.0141965606161204 |
GO:0042832 | defense response to protozoan | 0.0141965606161204 |
GO:0050710 | negative regulation of cytokine secretion | 0.0141965606161204 |
GO:0030502 | negative regulation of bone mineralization | 0.0141965606161204 |
GO:0048536 | spleen development | 0.0141965606161204 |
GO:0009617 | response to bacterium | 0.0148078715922745 |
GO:0007243 | protein kinase cascade | 0.0152684925342779 |
GO:0005737 | cytoplasm | 0.0163191090114548 |
GO:0042640 | anagen | 0.016636871488105 |
GO:0051457 | maintenance of protein localization in nucleus | 0.016636871488105 |
GO:0045064 | T-helper 2 cell differentiation | 0.016636871488105 |
GO:0032613 | interleukin-10 production | 0.016636871488105 |
GO:0001562 | response to protozoan | 0.016636871488105 |
GO:0032729 | positive regulation of interferon-gamma production | 0.016636871488105 |
GO:0000305 | response to oxygen radical | 0.016636871488105 |
GO:0006979 | response to oxidative stress | 0.0176996877048507 |
GO:0007242 | intracellular signaling cascade | 0.0185885031211321 |
GO:0032649 | regulation of interferon-gamma production | 0.0191248024712713 |
GO:0050709 | negative regulation of protein secretion | 0.0191248024712713 |
GO:0045090 | retroviral genome replication | 0.0191248024712713 |
GO:0042119 | neutrophil activation | 0.0191248024712713 |
GO:0050856 | regulation of T cell receptor signaling pathway | 0.0191248024712713 |
GO:0048015 | phosphoinositide-mediated signaling | 0.0195290363614825 |
GO:0048856 | anatomical structure development | 0.0196642202669524 |
GO:0048820 | hair follicle maturation | 0.0217847238095414 |
GO:0045671 | negative regulation of osteoclast differentiation | 0.0217847238095414 |
GO:0007249 | I-kappaB kinase/NF-kappaB cascade | 0.0220501452142255 |
GO:0045184 | establishment of protein localization | 0.0236494678176184 |
GO:0045414 | regulation of interleukin-8 biosynthetic process | 0.0236494678176184 |
GO:0030279 | negative regulation of ossification | 0.0236494678176184 |
GO:0045576 | mast cell activation | 0.0236494678176184 |
GO:0042771 | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | 0.0236494678176184 |
GO:0042534 | regulation of tumor necrosis factor biosynthetic process | 0.0236494678176184 |
GO:0042533 | tumor necrosis factor biosynthetic process | 0.0236494678176184 |
GO:0050930 | induction of positive chemotaxis | 0.0236494678176184 |
GO:0043231 | intracellular membrane-bound organelle | 0.0254693686739627 |
GO:0043227 | membrane-bound organelle | 0.0254693686739627 |
GO:0045670 | regulation of osteoclast differentiation | 0.0254693686739627 |
GO:0042116 | macrophage activation | 0.0254693686739627 |
GO:0042228 | interleukin-8 biosynthetic process | 0.0254693686739627 |
GO:0002762 | negative regulation of myeloid leukocyte differentiation | 0.0254693686739627 |
GO:0016721 | oxidoreductase activity, acting on superoxide radicals as acceptor | 0.0254693686739627 |
GO:0004784 | superoxide dismutase activity | 0.0254693686739627 |
GO:0008104 | protein localization | 0.0257040568900661 |
GO:0030097 | hemopoiesis | 0.0257040568900661 |
GO:0044424 | intracellular part | 0.0257040568900661 |
GO:0050926 | regulation of positive chemotaxis | 0.0257040568900661 |
GO:0045408 | regulation of interleukin-6 biosynthetic process | 0.0257040568900661 |
GO:0001516 | prostaglandin biosynthetic process | 0.0257040568900661 |
GO:0002286 | T cell activation during immune response | 0.0257040568900661 |
GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 0.0257040568900661 |
GO:0046457 | prostanoid biosynthetic process | 0.0257040568900661 |
GO:0002292 | T cell differentiation during immune response | 0.0257040568900661 |
GO:0002293 | alpha-beta T cell differentiation during immune response | 0.0257040568900661 |
GO:0002263 | cell activation during immune response | 0.0257040568900661 |
GO:0002294 | CD4-positive, alpha-beta T cell differentiation during immune response | 0.0257040568900661 |
GO:0042092 | T-helper 2 type immune response | 0.0257040568900661 |
GO:0042093 | T-helper cell differentiation | 0.0257040568900661 |
GO:0002366 | leukocyte activation during immune response | 0.0257040568900661 |
GO:0002285 | lymphocyte activation during immune response | 0.0257040568900661 |
GO:0050927 | positive regulation of positive chemotaxis | 0.0257040568900661 |
GO:0050918 | positive chemotaxis | 0.0257040568900661 |
GO:0048534 | hemopoietic or lymphoid organ development | 0.0272051820618708 |
GO:0050921 | positive regulation of chemotaxis | 0.0272051820618708 |
GO:0051101 | regulation of DNA binding | 0.0272051820618708 |
GO:0043367 | CD4-positive, alpha beta T cell differentiation | 0.0272051820618708 |
GO:0046851 | negative regulation of bone remodeling | 0.0272051820618708 |
GO:0030316 | osteoclast differentiation | 0.0272051820618708 |
GO:0032637 | interleukin-8 production | 0.0272051820618708 |
GO:0030500 | regulation of bone mineralization | 0.0272051820618708 |
GO:0033036 | macromolecule localization | 0.0272051820618708 |
GO:0005615 | extracellular space | 0.027363362714516 |
GO:0002520 | immune system development | 0.0283656632143117 |
GO:0050920 | regulation of chemotaxis | 0.0283656632143117 |
GO:0042348 | NF-kappaB import into nucleus | 0.0283656632143117 |
GO:0042226 | interleukin-6 biosynthetic process | 0.0283656632143117 |
GO:0030593 | neutrophil chemotaxis | 0.0283656632143117 |
GO:0051605 | protein maturation via proteolysis | 0.0283656632143117 |
GO:0042345 | regulation of NF-kappaB import into nucleus | 0.0283656632143117 |
GO:0050832 | defense response to fungus | 0.0283656632143117 |
GO:0001836 | release of cytochrome c from mitochondria | 0.0303148621582159 |
GO:0032640 | tumor necrosis factor production | 0.0303148621582159 |
GO:0045069 | regulation of viral genome replication | 0.0303148621582159 |
GO:0042981 | regulation of apoptosis | 0.0319019423321378 |
GO:0051604 | protein maturation | 0.0322118294305836 |
GO:0009595 | detection of biotic stimulus | 0.0322118294305836 |
GO:0043067 | regulation of programmed cell death | 0.032391407482829 |
GO:0005764 | lysosome | 0.0331077455322376 |
GO:0000323 | lytic vacuole | 0.0332796856566326 |
GO:0032635 | interleukin-6 production | 0.0336292571048591 |
GO:0001890 | placenta development | 0.0336292571048591 |
GO:0002761 | regulation of myeloid leukocyte differentiation | 0.0336292571048591 |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 0.034832489986551 |
GO:0050707 | regulation of cytokine secretion | 0.034832489986551 |
GO:0046632 | alpha-beta T cell differentiation | 0.034832489986551 |
GO:0042036 | negative regulation of cytokine biosynthetic process | 0.034832489986551 |
GO:0007202 | phospholipase C activation | 0.034832489986551 |
GO:0016050 | vesicle organization and biogenesis | 0.034832489986551 |
GO:0045444 | fat cell differentiation | 0.034832489986551 |
GO:0006917 | induction of apoptosis | 0.0348486356483192 |
GO:0012502 | induction of programmed cell death | 0.0350188135331035 |
GO:0016564 | transcription repressor activity | 0.0351888414433236 |
GO:0050792 | regulation of viral reproduction | 0.0356839973157255 |
GO:0050852 | T cell receptor signaling pathway | 0.0356839973157255 |
GO:0006692 | prostanoid metabolic process | 0.0356839973157255 |
GO:0031901 | early endosome membrane | 0.0356839973157255 |
GO:0051048 | negative regulation of secretion | 0.0356839973157255 |
GO:0006693 | prostaglandin metabolic process | 0.0356839973157255 |
GO:0022405 | hair cycle process | 0.0364856949867669 |
GO:0032609 | interferon-gamma production | 0.0364856949867669 |
GO:0042633 | hair cycle | 0.0364856949867669 |
GO:0022404 | molting cycle process | 0.0364856949867669 |
GO:0001942 | hair follicle development | 0.0364856949867669 |
GO:0042303 | molting cycle | 0.0364856949867669 |
GO:0045638 | negative regulation of myeloid cell differentiation | 0.0364856949867669 |
GO:0008285 | negative regulation of cell proliferation | 0.0364856949867669 |
GO:0045786 | negative regulation of progression through cell cycle | 0.0364856949867669 |
GO:0016043 | cellular component organization and biogenesis | 0.0366472503545525 |
GO:0046631 | alpha-beta T cell activation | 0.0377687402963367 |
GO:0030278 | regulation of ossification | 0.0377687402963367 |
GO:0008630 | DNA damage response, signal transduction resulting in induction of apoptosis | 0.0377687402963367 |
GO:0008637 | apoptotic mitochondrial changes | 0.0377687402963367 |
GO:0005773 | vacuole | 0.038105137103877 |
GO:0045859 | regulation of protein kinase activity | 0.0390129481834106 |
GO:0042542 | response to hydrogen peroxide | 0.0390129481834106 |
GO:0030282 | bone mineralization | 0.0390129481834106 |
GO:0005626 | insoluble fraction | 0.0390129481834106 |
GO:0006412 | translation | 0.0390929441439382 |
GO:0043549 | regulation of kinase activity | 0.0400328905409625 |
GO:0006801 | superoxide metabolic process | 0.0402108885406451 |
GO:0042990 | regulation of transcription factor import into nucleus | 0.0402108885406451 |
GO:0042991 | transcription factor import into nucleus | 0.0402108885406451 |
GO:0065009 | regulation of a molecular function | 0.0406298812614006 |
GO:0051338 | regulation of transferase activity | 0.0408596433951566 |
GO:0033157 | regulation of intracellular protein transport | 0.041219363387219 |
GO:0042306 | regulation of protein import into nucleus | 0.041219363387219 |
GO:0030139 | endocytic vesicle | 0.041219363387219 |
GO:0000060 | protein import into nucleus, translocation | 0.041219363387219 |
GO:0001819 | positive regulation of cytokine production | 0.0426329487877967 |
GO:0030595 | leukocyte chemotaxis | 0.0426329487877967 |
GO:0043065 | positive regulation of apoptosis | 0.0426329487877967 |
GO:0043068 | positive regulation of programmed cell death | 0.0431091079967831 |
GO:0046850 | regulation of bone remodeling | 0.0439882509742389 |
GO:0032507 | maintenance of cellular protein localization | 0.0439882509742389 |
GO:0044249 | cellular biosynthetic process | 0.0439882509742389 |
GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0439882509742389 |
GO:0031347 | regulation of defense response | 0.0447366974570079 |
GO:0050727 | regulation of inflammatory response | 0.0447366974570079 |
GO:0032386 | regulation of intracellular transport | 0.0447366974570079 |
GO:0051241 | negative regulation of multicellular organismal process | 0.0447366974570079 |
GO:0051651 | maintenance of cellular localization | 0.0447366974570079 |
GO:0050708 | regulation of protein secretion | 0.0461966376457733 |
GO:0016599 | caveolar membrane | 0.0461966376457733 |
GO:0051239 | regulation of multicellular organismal process | 0.0472621212070386 |
GO:0000302 | response to reactive oxygen species | 0.0474780523200585 |
GO:0050851 | antigen receptor-mediated signaling pathway | 0.0474780523200585 |
GO:0005887 | integral to plasma membrane | 0.0485736303885399 |
GO:0016044 | membrane organization and biogenesis | 0.0485736303885399 |
GO:0051223 | regulation of protein transport | 0.0485736303885399 |
GO:0051098 | regulation of binding | 0.0485736303885399 |
GO:0031226 | intrinsic to plasma membrane | 0.0494799751479102 |
GO:0046822 | regulation of nucleocytoplasmic transport | 0.0494799751479102 |
GO:0019079 | viral genome replication | 0.0494799751479102 |
GO:0005901 | caveola | 0.0494799751479102 |
GO:0030183 | B cell differentiation | 0.0494799751479102 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
hematopoietic system | 1.37e-78 | 98 |
blood island | 1.37e-78 | 98 |
hemolymphoid system | 7.29e-70 | 108 |
bone marrow | 4.31e-66 | 76 |
bone element | 2.79e-60 | 82 |
immune system | 2.16e-58 | 93 |
skeletal element | 9.94e-54 | 90 |
skeletal system | 5.26e-47 | 100 |
lateral plate mesoderm | 6.08e-31 | 203 |
musculoskeletal system | 9.54e-23 | 167 |
mesoderm | 4.69e-15 | 315 |
mesoderm-derived structure | 4.69e-15 | 315 |
presumptive mesoderm | 4.69e-15 | 315 |
connective tissue | 5.38e-14 | 371 |
blood | 3.21e-11 | 15 |
haemolymphatic fluid | 3.21e-11 | 15 |
organism substance | 3.21e-11 | 15 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 2.81584e-14 |
MA0004.1 | 0.00608749 |
MA0006.1 | 0.113957 |
MA0007.1 | 0.0281868 |
MA0009.1 | 0.264004 |
MA0014.1 | 8.19678e-15 |
MA0017.1 | 0.147413 |
MA0019.1 | 0.505921 |
MA0024.1 | 0.0531496 |
MA0025.1 | 0.810886 |
MA0027.1 | 1.19827 |
MA0028.1 | 0.000465746 |
MA0029.1 | 0.061567 |
MA0030.1 | 0.15241 |
MA0031.1 | 0.207764 |
MA0038.1 | 0.0726003 |
MA0040.1 | 2.01726 |
MA0041.1 | 0.880288 |
MA0042.1 | 1.85959 |
MA0043.1 | 0.26442 |
MA0046.1 | 0.0236623 |
MA0048.1 | 0.00356235 |
MA0050.1 | 0.180328 |
MA0051.1 | 0.350482 |
MA0052.1 | 0.0661032 |
MA0055.1 | 0.000400034 |
MA0056.1 | 0 |
MA0057.1 | 0.000181905 |
MA0058.1 | 0.00580739 |
MA0059.1 | 0.295979 |
MA0060.1 | 5.96131e-07 |
MA0061.1 | 0.190684 |
MA0063.1 | 0 |
MA0066.1 | 0.139439 |
MA0067.1 | 0.133805 |
MA0068.1 | 0.371628 |
MA0069.1 | 0.244931 |
MA0070.1 | 0.0926055 |
MA0071.1 | 0.0910146 |
MA0072.1 | 0.225438 |
MA0073.1 | 0.107122 |
MA0074.1 | 0.0299644 |
MA0076.1 | 0.0194468 |
MA0077.1 | 0.415001 |
MA0078.1 | 0.181204 |
MA0081.1 | 0.052354 |
MA0083.1 | 0.0270626 |
MA0084.1 | 1.2573 |
MA0087.1 | 1.02465 |
MA0088.1 | 0.0151452 |
MA0089.1 | 0 |
MA0090.1 | 0.310707 |
MA0091.1 | 0.00640894 |
MA0092.1 | 0.924791 |
MA0093.1 | 0.000973146 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0847493 |
MA0101.1 | 0.0832564 |
MA0103.1 | 0.369407 |
MA0105.1 | 0.0659236 |
MA0106.1 | 0.112385 |
MA0107.1 | 0.136111 |
MA0108.2 | 0.363761 |
MA0109.1 | 0 |
MA0111.1 | 0.637802 |
MA0113.1 | 0.549833 |
MA0114.1 | 0.083889 |
MA0115.1 | 0.325356 |
MA0116.1 | 0.0147633 |
MA0117.1 | 0.0332939 |
MA0119.1 | 0.0383641 |
MA0122.1 | 0.354237 |
MA0124.1 | 0.990124 |
MA0125.1 | 0.197644 |
MA0130.1 | 0 |
MA0131.1 | 0.0449409 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.305544 |
MA0136.1 | 0.0786254 |
MA0139.1 | 0.000507373 |
MA0140.1 | 0.0433463 |
MA0141.1 | 0.394054 |
MA0142.1 | 0.492028 |
MA0143.1 | 0.373639 |
MA0144.1 | 0.173234 |
MA0145.1 | 0.000349724 |
MA0146.1 | 0.00145119 |
MA0147.1 | 0.0289542 |
MA0148.1 | 0.392786 |
MA0149.1 | 0.492889 |
MA0062.2 | 4.61243e-06 |
MA0035.2 | 0.251265 |
MA0039.2 | 4.65495e-09 |
MA0138.2 | 0.183007 |
MA0002.2 | 0.868621 |
MA0137.2 | 0.430129 |
MA0104.2 | 0.000801925 |
MA0047.2 | 0.859789 |
MA0112.2 | 0.0706781 |
MA0065.2 | 0.0888801 |
MA0150.1 | 1.04727 |
MA0151.1 | 0 |
MA0152.1 | 0.74957 |
MA0153.1 | 0.0486099 |
MA0154.1 | 0.00378425 |
MA0155.1 | 0.00953078 |
MA0156.1 | 0.00515154 |
MA0157.1 | 0.418652 |
MA0158.1 | 0 |
MA0159.1 | 0.0755506 |
MA0160.1 | 0.612112 |
MA0161.1 | 0 |
MA0162.1 | 1.15719e-15 |
MA0163.1 | 4.14228e-05 |
MA0164.1 | 0.407414 |
MA0080.2 | 0.120586 |
MA0018.2 | 0.206319 |
MA0099.2 | 0.168756 |
MA0079.2 | 0 |
MA0102.2 | 0.265831 |
MA0258.1 | 0.50732 |
MA0259.1 | 0.00102101 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data