Coexpression cluster:C3336

Full id: C3336_mesothelioma_testicular_extraskeletal_Endothelial_Lens_pancreatic_Renal

Phase1 CAGE Peaks

Hg19::chr12:80084120..80084136,-	p15@PAWR
Hg19::chr12:80084137..80084165,-	p10@PAWR
Hg19::chr12:80084167..80084197,-	p5@PAWR

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	6.10e-33	254
squamous epithelial cell	8.98e-17	62
lining cell	6.62e-15	57
barrier cell	6.62e-15	57
embryonic cell	2.31e-14	248
endothelial cell of vascular tree	1.60e-12	24
mesothelial cell	1.87e-10	19
blood vessel endothelial cell	7.55e-09	18
embryonic blood vessel endothelial progenitor cell	7.55e-09	18
endothelial cell	2.20e-08	35
meso-epithelial cell	3.35e-08	44
mesodermal cell	7.31e-08	119
epithelial cell of nephron	9.93e-07	16

Uber Anatomy

Ontology term	p-value	n
subdivision of trunk	4.88e-11	113
epithelial tube	5.76e-11	118
body cavity precursor	7.64e-11	63
immaterial anatomical entity	5.29e-10	126
anatomical cavity	5.35e-10	70
simple squamous epithelium	1.60e-09	22
anatomical space	1.74e-09	104
abdominal segment of trunk	7.38e-09	61
abdomen	7.38e-09	61
endothelium	7.55e-09	18
blood vessel endothelium	7.55e-09	18
cardiovascular system endothelium	7.55e-09	18
vasculature	1.09e-08	79
vascular system	1.09e-08	79
duct	6.46e-08	26
anatomical cluster	1.07e-07	286
vessel	1.78e-07	69
squamous epithelium	2.11e-07	25
kidney	2.22e-07	27
kidney mesenchyme	2.22e-07	27
kidney rudiment	2.22e-07	27
kidney field	2.22e-07	27
trunk	2.41e-07	216
urogenital ridge	5.44e-07	20
abdomen element	7.94e-07	55
abdominal segment element	7.94e-07	55
intermediate mesoderm	8.38e-07	37
nephron epithelium	9.93e-07	16
nephron	9.93e-07	16
uriniferous tubule	9.93e-07	16
metanephric mesenchyme	9.93e-07	16
nephrogenic mesenchyme	9.93e-07	16

Disease

Ontology term	p-value	n
carcinoma	3.25e-12	106
cell type cancer	7.25e-12	143
cancer	6.21e-08	235
disease of cellular proliferation	1.09e-07	239

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0278709019626673
EBF1#1879	3	8.906466846569	0.0014152328356098	0.00913168800928286
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0460703964343273
MYC#4609	3	5.2222818716094	0.00702084375574015	0.029360530992462
RAD21#5885	3	10.3550338954563	0.000900491207356542	0.00662531885911306
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0328410189772067

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.