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Coexpression cluster:C3859: Difference between revisions

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|tf_chipseq_enrich=SMC3#9126;2:10.0299552299552:0.012665637976747:0.0457489992617238!ZZZ3#26009;1:79.8044041450777:0.012478437908258:0.0451618524690909
|tf_chipseq_enrich=SMC3#9126;2:10.0299552299552:0.012665637976747:0.0457489992617238!ZZZ3#26009;1:79.8044041450777:0.012478437908258:0.0451618524690909
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}}
}}

Revision as of 16:23, 26 November 2012


Full id: C3859_CD14_Fibroblast_Preadipocyte_Smooth_leiomyoma_tenocyte_Myoblast



Phase1 CAGE Peaks

Hg19::chr1:145096387..145096477,+p1@SEC22B
Hg19::chr1:145116327..145116343,+p@chr1:145116327..145116343
+
Hg19::chr4:122618095..122618161,-p1@ANXA5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0033116ER-Golgi intermediate compartment membrane0.0205762027448468
GO:0050819negative regulation of coagulation0.0205762027448468
GO:0050818regulation of coagulation0.0205762027448468
GO:0055102lipase inhibitor activity0.0205762027448468
GO:0004859phospholipase inhibitor activity0.0205762027448468
GO:0006888ER to Golgi vesicle-mediated transport0.0332505298680399
GO:0005793ER-Golgi intermediate compartment0.0332505298680399
GO:0005544calcium-dependent phospholipid binding0.0365310003594502
GO:0048770pigment granule0.0405595081249357
GO:0042470melanosome0.0405595081249357
GO:0048193Golgi vesicle transport0.0405595081249357
GO:0007596blood coagulation0.0405595081249357
GO:0050817coagulation0.0405595081249357
GO:0007599hemostasis0.0405595081249357
GO:0050878regulation of body fluid levels0.0442604929895272
GO:0042060wound healing0.0442604929895272



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
multi fate stem cell4.62e-31427
somatic stem cell1.62e-29433
stem cell3.77e-26441
somatic cell1.46e-21588
muscle precursor cell5.31e-1858
myoblast5.31e-1858
multi-potent skeletal muscle stem cell5.31e-1858
animal cell7.49e-18679
eukaryotic cell7.49e-18679
muscle cell1.27e-1655
connective tissue cell3.50e-16361
mesenchymal cell4.21e-15354
fibroblast4.38e-1576
contractile cell1.33e-1459
smooth muscle cell4.00e-1443
smooth muscle myoblast4.00e-1443
mesodermal cell5.30e-14121
native cell2.36e-13722
electrically responsive cell5.99e-1361
electrically active cell5.99e-1361
stuff accumulating cell1.30e-1287
defensive cell2.37e-1248
phagocyte2.37e-1248
vascular associated smooth muscle cell4.38e-1232
motile cell5.52e-12386
monopoietic cell1.60e-1159
monocyte1.60e-1159
monoblast1.60e-1159
promonocyte1.60e-1159
macrophage dendritic cell progenitor9.79e-1161
non-terminally differentiated cell1.39e-10106
classical monocyte3.37e-1042
CD14-positive, CD16-negative classical monocyte3.37e-1042
myeloid lineage restricted progenitor cell4.61e-1066
granulocyte monocyte progenitor cell1.69e-0867
myeloid leukocyte6.97e-0872
fat cell3.76e-0715
Uber Anatomy
Ontology termp-valuen
musculoskeletal system3.07e-27167
mesoderm5.72e-22315
mesoderm-derived structure5.72e-22315
presumptive mesoderm5.72e-22315
somite2.27e-1671
presomitic mesoderm2.27e-1671
presumptive segmental plate2.27e-1671
dermomyotome2.27e-1671
trunk paraxial mesoderm2.27e-1671
dense mesenchyme tissue2.46e-1673
paraxial mesoderm4.67e-1672
presumptive paraxial mesoderm4.67e-1672
connective tissue1.25e-15371
skeletal muscle tissue5.99e-1562
striated muscle tissue5.99e-1562
myotome5.99e-1562
muscle tissue2.98e-1464
musculature2.98e-1464
musculature of body2.98e-1464
multilaminar epithelium3.37e-1383
epithelial vesicle4.62e-1378
lateral plate mesoderm5.75e-12203
skeletal system1.34e-11100
trunk mesenchyme1.79e-11122
skeletal element1.41e-1090
unilaminar epithelium5.09e-10148
bone marrow6.15e-1076
artery1.25e-0942
arterial blood vessel1.25e-0942
arterial system1.25e-0942
bone element5.20e-0982
systemic artery7.94e-0933
systemic arterial system7.94e-0933
mesenchyme1.60e-08160
entire embryonic mesenchyme1.60e-08160
vasculature3.78e-0878
vascular system3.78e-0878
cardiovascular system1.79e-07109
splanchnic layer of lateral plate mesoderm1.96e-0783
immune system2.38e-0793
vessel7.60e-0768


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SMC3#9126210.02995522995520.0126656379767470.0457489992617238
ZZZ3#26009179.80440414507770.0124784379082580.0451618524690909



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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