Coexpression cluster:C2099

Full id: C2099_Adipocyte_Osteoblast_Mesenchymal_Endothelial_Renal_Retinal_Preadipocyte

Phase1 CAGE Peaks

Hg19::chr11:119211162..119211175,-	p2@AB590791
Hg19::chr11:119211254..119211316,-	p1@AB590791
Hg19::chr11:119211525..119211614,-	p1@C1QTNF5
Hg19::chr11:119211627..119211642,-	p4@C1QTNF5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006817	phosphate transport	0.034862043251305
GO:0015698	inorganic anion transport	0.034862043251305
GO:0006820	anion transport	0.034862043251305

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	9.13e-21	180
mesodermal cell	8.62e-19	119
endothelial cell	6.00e-16	35
endothelial cell of vascular tree	4.40e-15	24
meso-epithelial cell	1.75e-14	44
blood vessel endothelial cell	6.39e-12	18
embryonic blood vessel endothelial progenitor cell	6.39e-12	18
lining cell	2.40e-11	57
barrier cell	2.40e-11	57
fibroblast	1.76e-10	75
fat cell	1.17e-08	15
contractile cell	2.45e-08	59
muscle precursor cell	2.67e-08	57
myoblast	2.67e-08	57
multi-potent skeletal muscle stem cell	2.67e-08	57
muscle cell	6.87e-08	54
electrically responsive cell	1.89e-07	60
electrically active cell	1.89e-07	60
endothelial cell of artery	2.65e-07	9

Uber Anatomy

Ontology term	p-value	n
anatomical conduit	5.37e-21	241
epithelium	1.71e-20	309
anatomical cluster	1.98e-20	286
cell layer	2.73e-20	312
tube	2.93e-19	194
vasculature	3.33e-19	79
vascular system	3.33e-19	79
vessel	4.52e-19	69
splanchnic layer of lateral plate mesoderm	2.68e-18	84
epithelial tube	1.07e-16	118
blood vessel	1.88e-16	60
epithelial tube open at both ends	1.88e-16	60
blood vasculature	1.88e-16	60
vascular cord	1.88e-16	60
organism subdivision	1.92e-15	365
circulatory system	8.88e-15	113
cardiovascular system	2.71e-14	110
multi-cellular organism	4.56e-13	659
unilaminar epithelium	5.71e-13	138
adult organism	1.34e-12	115
endothelium	6.39e-12	18
blood vessel endothelium	6.39e-12	18
cardiovascular system endothelium	6.39e-12	18
multi-tissue structure	1.24e-10	347
squamous epithelium	6.56e-10	25
trunk mesenchyme	8.31e-10	143
muscle tissue	1.12e-09	63
musculature	1.12e-09	63
musculature of body	1.12e-09	63
anatomical system	2.46e-09	625
artery	2.89e-09	42
arterial blood vessel	2.89e-09	42
arterial system	2.89e-09	42
skeletal muscle tissue	3.35e-09	61
striated muscle tissue	3.35e-09	61
myotome	3.35e-09	61
simple squamous epithelium	3.42e-09	22
anatomical group	3.86e-09	626
neural plate	6.58e-09	86
presumptive neural plate	6.58e-09	86
somite	2.54e-08	83
paraxial mesoderm	2.54e-08	83
presomitic mesoderm	2.54e-08	83
presumptive segmental plate	2.54e-08	83
trunk paraxial mesoderm	2.54e-08	83
presumptive paraxial mesoderm	2.54e-08	83
dermomyotome	3.59e-08	70
neurectoderm	1.04e-07	90
neural tube	1.26e-07	57
neural rod	1.26e-07	57
future spinal cord	1.26e-07	57
neural keel	1.26e-07	57
systemic artery	1.52e-07	33
systemic arterial system	1.52e-07	33
trunk	2.32e-07	216
endothelial tube	2.65e-07	9
arterial system endothelium	2.65e-07	9
endothelium of artery	2.65e-07	9
regional part of brain	3.62e-07	59
aorta	5.95e-07	21
aortic system	5.95e-07	21
multilaminar epithelium	6.90e-07	82

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.