MCL coexpression mm9:1306

Phase1 CAGE Peaks

	Short description
Mm9::chr11:87570427..87570431,+	p2@Mir142
Mm9::chr1:167615652..167615656,-	p@chr1:167615652..167615656 -
Mm9::chr5:86539268..86539274,+	p@chr5:86539268..86539274 +
Mm9::chr6:145070282..145070315,+	p1@Lrmp
Mm9::chr6:145072003..145072005,+	p@chr6:145072003..145072005 +
Mm9::chr6:145111646..145111650,+	p@chr6:145111646..145111650 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004839	ubiquitin activating enzyme activity	0.0157752026064506
GO:0008641	small protein activating enzyme activity	0.0157752026064506

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
hemopoietic organ	8.53e-14	29
immune organ	8.53e-14	29
hematopoietic system	2.56e-12	45
blood island	2.56e-12	45
hemolymphoid system	8.45e-12	48
immune system	8.45e-12	48
mixed endoderm/mesoderm-derived structure	1.12e-11	35
foregut	2.91e-11	80
gland of gut	2.19e-10	24
thymus	3.10e-10	23
neck	3.10e-10	23
respiratory system epithelium	3.10e-10	23
hemolymphoid system gland	3.10e-10	23
pharyngeal epithelium	3.10e-10	23
thymic region	3.10e-10	23
pharyngeal gland	3.10e-10	23
entire pharyngeal arch endoderm	3.10e-10	23
thymus primordium	3.10e-10	23
early pharyngeal endoderm	3.10e-10	23
pharynx	1.93e-09	24
upper respiratory tract	1.93e-09	24
chordate pharynx	1.93e-09	24
pharyngeal arch system	1.93e-09	24
pharyngeal region of foregut	1.93e-09	24
endocrine system	9.99e-09	72
organism subdivision	7.30e-08	150
respiratory system	7.99e-08	42
endo-epithelium	9.02e-08	69
respiratory tract	1.25e-07	41
endocrine gland	1.41e-07	60
gland	1.81e-07	65
segment of respiratory tract	1.83e-07	27
gut epithelium	5.17e-07	55
lateral plate mesoderm	5.88e-07	87

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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