Coexpression cluster:C389

Full id: C389_heart_left_umbilical_skin_skeletal_trachea_throat

Phase1 CAGE Peaks

Hg19::chr10:25242626..25242636,-	p@chr10:25242626..25242636 -
Hg19::chr12:114886577..114886589,-	p@chr12:114886577..114886589 -
Hg19::chr12:4735761..4735787,-	p@chr12:4735761..4735787 -
Hg19::chr13:93329902..93329916,-	p@chr13:93329902..93329916 -
Hg19::chr14:23853394..23853399,-	p@chr14:23853394..23853399 -
Hg19::chr14:23854188..23854193,-	p@chr14:23854188..23854193 -
Hg19::chr14:23854202..23854211,-	p@chr14:23854202..23854211 -
Hg19::chr14:23862577..23862585,-	p5@MYH6
Hg19::chr14:23862929..23862940,-	p@chr14:23862929..23862940 -
Hg19::chr14:23863036..23863066,-	p@chr14:23863036..23863066 -
Hg19::chr14:23863088..23863103,-	p@chr14:23863088..23863103 -
Hg19::chr14:23863108..23863123,-	p@chr14:23863108..23863123 -
Hg19::chr14:23863373..23863402,-	p@chr14:23863373..23863402 -
Hg19::chr14:23863442..23863452,-	p@chr14:23863442..23863452 -
Hg19::chr14:23867985..23867992,-	p@chr14:23867985..23867992 -
Hg19::chr14:23872542..23872556,-	p@chr14:23872542..23872556 -
Hg19::chr14:23876809..23876833,-	p8@MYH6
Hg19::chr14:23877474..23877491,-	p1@MYH6
Hg19::chr19:56057552..56057564,-	p@chr19:56057552..56057564 -
Hg19::chr2:159976509..159976519,+	p@chr2:159976509..159976519 +
Hg19::chr3:178103144..178103153,-	p1@ENST00000417383
Hg19::chr4:174926997..174927004,+	p@chr4:174926997..174927004 +
Hg19::chr5:117897774..117897788,-	p1@ENST00000506769 p1@ENST00000515704
Hg19::chr5:148803658..148803668,+	p@chr5:148803658..148803668 +
Hg19::chr7:25815812..25815822,-	p@chr7:25815812..25815822 -
Hg19::chr7:44178491..44178498,-	p@chr7:44178491..44178498 -
Hg19::chr8:111668033..111668039,+	p@chr8:111668033..111668039 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0055009	atrial cardiac muscle morphogenesis	0.00230254981226369
GO:0030898	actin-dependent ATPase activity	0.00230254981226369
GO:0030049	muscle filament sliding	0.00230254981226369
GO:0033275	actin-myosin filament sliding	0.00230254981226369
GO:0002027	regulation of heart rate	0.00230254981226369
GO:0055010	ventricular cardiac muscle morphogenesis	0.00230254981226369
GO:0007512	adult heart development	0.00230254981226369
GO:0048644	muscle morphogenesis	0.00230254981226369
GO:0055008	cardiac muscle morphogensis	0.00230254981226369
GO:0000146	microfilament motor activity	0.00318814589390358
GO:0030048	actin filament-based movement	0.00318814589390358
GO:0032982	myosin filament	0.00318814589390358
GO:0005863	striated muscle thick filament	0.00318814589390358
GO:0005859	muscle myosin complex	0.0044899721339142
GO:0016460	myosin II complex	0.0044899721339142
GO:0006941	striated muscle contraction	0.00592084237439235
GO:0008016	regulation of heart contraction	0.00592084237439235
GO:0008307	structural constituent of muscle	0.00592084237439235
GO:0060047	heart contraction	0.00592084237439235
GO:0003015	heart process	0.00592084237439235
GO:0030017	sarcomere	0.00592084237439235
GO:0030016	myofibril	0.00624043329801013
GO:0044449	contractile fiber part	0.00675748314468692
GO:0043292	contractile fiber	0.00690764943679108
GO:0007507	heart development	0.00973978570587542
GO:0016459	myosin complex	0.0106603628327401
GO:0005516	calmodulin binding	0.0135274801470492
GO:0008015	blood circulation	0.0137874454484338
GO:0003013	circulatory system process	0.0137874454484338
GO:0003012	muscle system process	0.0137874454484338
GO:0006936	muscle contraction	0.0137874454484338
GO:0007517	muscle development	0.013923230896032
GO:0030705	cytoskeleton-dependent intracellular transport	0.0153852192001256
GO:0030029	actin filament-based process	0.019808700590798
GO:0051239	regulation of multicellular organismal process	0.0205009167213335
GO:0015629	actin cytoskeleton	0.0212985857634392
GO:0009887	organ morphogenesis	0.0253436057039024
GO:0003779	actin binding	0.0298574057892878
GO:0042623	ATPase activity, coupled	0.0350696048329393
GO:0008092	cytoskeletal protein binding	0.0390498057223596
GO:0016887	ATPase activity	0.0397400441683682
GO:0007010	cytoskeleton organization and biogenesis	0.0423093528003454

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
valve	3.54e-74	3
cardiac mesenchyme	3.54e-74	3
cardial valve	3.54e-74	3
tunica intima	3.54e-74	3
heart layer	3.54e-74	3
endocardium	3.54e-74	3
endocardial cushion	3.54e-74	3
presumptive endocardium	3.54e-74	3
primary circulatory organ	3.24e-58	27
atrioventricular valve	3.11e-50	2
cardiac atrium	4.00e-50	2
future cardiac atrium	4.00e-50	2
cardiac chamber	7.70e-34	3
blood vessel layer	2.31e-32	7
mitral valve	2.16e-26	1
left cardiac atrium	2.78e-26	1
heart	4.95e-26	24
primitive heart tube	4.95e-26	24
primary heart field	4.95e-26	24
anterior lateral plate mesoderm	4.95e-26	24
heart tube	4.95e-26	24
heart primordium	4.95e-26	24
cardiac mesoderm	4.95e-26	24
cardiogenic plate	4.95e-26	24
heart rudiment	4.95e-26	24
pulmonary valve	7.62e-26	1
semi-lunar valve	7.62e-26	1
tricuspid valve	9.79e-26	1
right atrium valve	9.79e-26	1
outflow tract of atrium	9.79e-26	1
outflow part of right atrium	9.79e-26	1
right cardiac atrium	9.79e-26	1
compound organ	2.94e-23	68
neural crest-derived structure	6.42e-23	10
neural crest	6.42e-23	10
neural fold	6.42e-23	10
circulatory system	3.77e-14	112
adult organism	1.15e-10	114
outflow tract	1.67e-09	3
splanchnic layer of lateral plate mesoderm	1.03e-07	83

Disease

Ontology term	p-value	n
heart disease	3.11e-50	2
vascular disease	5.93e-26	1
ischemia	5.93e-26	1
extrinsic cardiomyopathy	5.93e-26	1
myocardial ischemia	5.93e-26	1
myocardial infarction	5.93e-26	1
cardiovascular system disease	9.82e-26	4

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.