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Coexpression cluster:C4795: Difference between revisions

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|full_id=C4795_chronic_hairy_Trabecular_Alveolar_Mesenchymal_Renal_CD14CD16
|full_id=C4795_chronic_hairy_Trabecular_Alveolar_Mesenchymal_Renal_CD14CD16
|id=C4795
|id=C4795
|ontology_enrichment_celltype=CL:0000012!2.67e-25!682;CL:0000548!1.26e-24!679;CL:0000004!1.26e-24!679;CL:0000255!1.26e-24!679;CL:0000003!2.01e-21!722;CL:0000144!7.85e-13!625;CL:0000066!9.48e-13!254;CL:0002371!6.14e-12!591;CL:0000063!4.92e-11!578;CL:0000220!1.36e-08!246;CL:0002321!1.65e-08!248;CL:0000071!5.45e-07!18;CL:0002546!5.45e-07!18;CL:0000222!5.55e-07!119;CL:0000115!7.70e-07!35
|ontology_enrichment_celltype=CL:0000548!1.00e-22!679;CL:0000255!1.00e-22!679;CL:0000003!4.15e-19!722;CL:0000066!1.70e-11!253;CL:0002371!7.01e-11!588;CL:0002321!1.20e-07!250;CL:1000449!2.11e-07!15;CL:0000115!9.08e-07!36
|ontology_enrichment_disease=DOID:162!7.45e-16!235;DOID:14566!4.69e-15!239;DOID:2531!1.51e-13!51;DOID:0060083!1.51e-13!51;DOID:1240!1.83e-11!39;DOID:0050686!1.70e-09!137;DOID:8692!3.56e-09!31;DOID:305!5.27e-07!106
|ontology_enrichment_disease=DOID:162!3.11e-15!235;DOID:14566!1.66e-14!239;DOID:2531!2.44e-14!51;DOID:0060083!2.44e-14!51;DOID:1240!5.00e-12!39;DOID:8692!1.99e-09!31;DOID:0050686!2.07e-09!137
|ontology_enrichment_uberon=UBERON:0000487!7.42e-08!22;UBERON:0001986!5.45e-07!18;UBERON:0004638!5.45e-07!18;UBERON:0004852!5.45e-07!18
|ontology_enrichment_uberon=UBERON:0004211!2.11e-07!15;UBERON:0009773!2.11e-07!15;UBERON:0001231!2.11e-07!15;UBERON:0001285!2.11e-07!15;UBERON:0007684!2.11e-07!15;UBERON:0004208!2.11e-07!15;UBERON:0000487!4.79e-07!22;UBERON:0006555!6.27e-07!16;UBERON:0004819!6.27e-07!16
|tf_chipseq_enrich=CEBPB#1051;3:7.97114762582482:0.00197418705528856:0.011587171061441!CTCF#10664;3:5.36025637307503:0.006492509252767:0.0281661200402814!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0322812800529518!MYC#4609;3:5.2222818716094:0.00702084375574015:0.029638233670402!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0278564041205292!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0331509797113301!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0110219011287719
|tf_chipseq_enrich=CEBPB#1051;3:7.97114762582482:0.00197418705528856:0.011587171061441!CTCF#10664;3:5.36025637307503:0.006492509252767:0.0281661200402814!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0322812800529518!MYC#4609;3:5.2222818716094:0.00702084375574015:0.029638233670402!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0278564041205292!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0331509797113301!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0110219011287719
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}}
}}

Revision as of 16:15, 19 October 2012


Full id: C4795_chronic_hairy_Trabecular_Alveolar_Mesenchymal_Renal_CD14CD16



Phase1 CAGE Peaks

Hg19::chr9:123639433..123639444,-p5@PHF19
Hg19::chr9:123639445..123639476,-p1@PHF19
Hg19::chr9:123639480..123639503,-p2@PHF19


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
animal cell1.00e-22679
eukaryotic cell1.00e-22679
native cell4.15e-19722
epithelial cell1.70e-11253
somatic cell7.01e-11588
embryonic cell1.20e-07250
epithelial cell of nephron2.11e-0715
endothelial cell9.08e-0736
Uber Anatomy
Ontology termp-valuen
nephron epithelium2.11e-0715
renal tubule2.11e-0715
nephron tubule2.11e-0715
nephron2.11e-0715
uriniferous tubule2.11e-0715
nephrogenic mesenchyme2.11e-0715
simple squamous epithelium4.79e-0722
excretory tube6.27e-0716
kidney epithelium6.27e-0716
Disease
Ontology termp-valuen
cancer3.11e-15235
disease of cellular proliferation1.66e-14239
hematologic cancer2.44e-1451
immune system cancer2.44e-1451
leukemia5.00e-1239
myeloid leukemia1.99e-0931
organ system cancer2.07e-09137


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105137.971147625824820.001974187055288560.011587171061441
CTCF#1066435.360256373075030.0064925092527670.0281661200402814
EGR1#195834.988179094810140.008056488137383440.0322812800529518
MYC#460935.22228187160940.007020843755740150.029638233670402
SIN3A#2594235.408884726815140.006318961977991520.0278564041205292
YY1#752834.911170749853860.008441455341808260.0331509797113301
ZNF263#1012738.221841637010680.001799043925565870.0110219011287719



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.