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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.00494748756215163,-0

Latest revision as of 14:14, 17 September 2013


Full id: C4512_CD4_Neutrophils_CD14_plasma_CD8_Peripheral_Eosinophils



Phase1 CAGE Peaks

Hg19::chr5:64859206..64859218,+p3@PPWD1
Hg19::chr5:64859227..64859241,+p2@PPWD1
Hg19::chrX:11778228..11778347,+p2@MSL3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0003755peptidyl-prolyl cis-trans isomerase activity0.0406216884493112
GO:0016859cis-trans isomerase activity0.0406216884493112
GO:0005681spliceosome0.0406216884493112
GO:0008380RNA splicing0.0406216884493112
GO:0006397mRNA processing0.0406216884493112
GO:0016853isomerase activity0.0406216884493112
GO:0016071mRNA metabolic process0.0406216884493112
GO:0006457protein folding0.0406216884493112



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte4.81e-47136
hematopoietic stem cell1.08e-46168
angioblastic mesenchymal cell1.08e-46168
hematopoietic cell2.73e-44177
hematopoietic oligopotent progenitor cell7.56e-43161
hematopoietic multipotent progenitor cell7.56e-43161
nongranular leukocyte1.96e-38115
hematopoietic lineage restricted progenitor cell1.71e-36120
myeloid cell8.76e-23108
common myeloid progenitor8.76e-23108
myeloid leukocyte1.01e-2172
classical monocyte1.08e-2142
CD14-positive, CD16-negative classical monocyte1.08e-2142
granulocyte monocyte progenitor cell6.79e-1967
lymphocyte8.52e-1953
common lymphoid progenitor8.52e-1953
macrophage dendritic cell progenitor1.48e-1861
lymphoid lineage restricted progenitor cell2.68e-1852
nucleate cell7.21e-1855
defensive cell1.31e-1748
phagocyte1.31e-1748
monopoietic cell1.32e-1759
monocyte1.32e-1759
monoblast1.32e-1759
promonocyte1.32e-1759
myeloid lineage restricted progenitor cell6.92e-1766
mature alpha-beta T cell2.53e-1118
alpha-beta T cell2.53e-1118
immature T cell2.53e-1118
mature T cell2.53e-1118
immature alpha-beta T cell2.53e-1118
mesenchymal cell1.28e-10354
T cell4.14e-1025
pro-T cell4.14e-1025
motile cell1.04e-09386
connective tissue cell2.79e-09361
B cell3.91e-0814
lymphocyte of B lineage5.76e-0824
pro-B cell5.76e-0824
CD8-positive, alpha-beta T cell1.04e-0711
Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.13e-24108
hematopoietic system3.93e-2398
blood island3.93e-2398
immune system4.08e-1993
bone marrow3.34e-1576
bone element1.61e-1482
skeletal element3.36e-1290
skeletal system8.16e-10100
connective tissue3.34e-09371
lateral plate mesoderm6.45e-07203
blood8.22e-0715
haemolymphatic fluid8.22e-0715
organism substance8.22e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.00160703
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467214.97544968400580.005768294540793880.0259692608649871
BRCA1#672213.45615376214920.007119807716084560.0296426389499763
IRF3#3661231.32130147432640.001339514673320110.00887900310782429
MAFK#7975218.06715542521990.003983674744936810.0191173554512914
NFYA#4800212.28372046655370.008516011403724430.0324908203037033
NFYB#4801211.17319550235760.01025467135054530.0381514541600028
NR3C1#290829.982015554115360.01278474365547170.046074045639538
SIX5#147912211.3911435703060.009873820081429030.0370886165833825



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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