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Coexpression cluster:C4331

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Full id: C4331_CD14_acute_Whole_blood_CD4_biphenotypic_CD19



Phase1 CAGE Peaks

Hg19::chr3:46395509..46395522,+p5@CCR2
Hg19::chr3:46395543..46395554,+p6@CCR2
Hg19::chr3:46395563..46395578,+p3@CCR2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
monopoietic cell1.81e-3259
monocyte1.81e-3259
monoblast1.81e-3259
promonocyte1.81e-3259
classical monocyte9.92e-3242
CD14-positive, CD16-negative classical monocyte9.92e-3242
macrophage dendritic cell progenitor4.12e-3161
myeloid leukocyte9.97e-3172
myeloid cell2.09e-29108
common myeloid progenitor2.09e-29108
defensive cell5.37e-2948
phagocyte5.37e-2948
myeloid lineage restricted progenitor cell4.43e-2866
granulocyte monocyte progenitor cell1.58e-2767
hematopoietic stem cell2.26e-22168
angioblastic mesenchymal cell2.26e-22168
nongranular leukocyte9.06e-21115
hematopoietic cell1.49e-20177
hematopoietic oligopotent progenitor cell2.85e-20161
hematopoietic multipotent progenitor cell2.85e-20161
leukocyte2.38e-19136
hematopoietic lineage restricted progenitor cell8.12e-16120
stuff accumulating cell1.39e-1287
single nucleate cell9.51e-083
mononuclear cell9.51e-083
basophil1.51e-073
Uber Anatomy
Ontology termp-valuen
hematopoietic system7.65e-4298
blood island7.65e-4298
hemolymphoid system1.75e-40108
immune system1.51e-2493
bone marrow3.24e-2376
blood7.49e-2215
haemolymphatic fluid7.49e-2215
organism substance7.49e-2215
bone element7.16e-2182
skeletal element3.08e-1890
skeletal system1.49e-15100
lateral plate mesoderm1.30e-13203
mesoderm4.83e-07315
mesoderm-derived structure4.83e-07315
presumptive mesoderm4.83e-07315
Disease
Ontology termp-valuen
myeloid leukemia1.23e-0731


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.