Coexpression cluster:C221
From FANTOM5_SSTAR
Full id: C221_alveolar_Osteoblast_Myoblast_mesenchymal_liposarcoma_Smooth_hepatocellular
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0019887 | protein kinase regulator activity | 0.0272063216252323 |
| GO:0051302 | regulation of cell division | 0.0272063216252323 |
| GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity | 0.0272063216252323 |
| GO:0019207 | kinase regulator activity | 0.0272063216252323 |
| GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity | 0.0292212530700774 |
| GO:0030971 | receptor tyrosine kinase binding | 0.0292212530700774 |
| GO:0006002 | fructose 6-phosphate metabolic process | 0.0292212530700774 |
| GO:0030296 | protein tyrosine kinase activator activity | 0.0383416067561451 |
| GO:0005031 | tumor necrosis factor receptor activity | 0.0454285307791918 |
| GO:0043120 | tumor necrosis factor binding | 0.0459896188608919 |
| GO:0005035 | death receptor activity | 0.0464473247508643 |
| GO:0016538 | cyclin-dependent protein kinase regulator activity | 0.0468274943289149 |
| GO:0030295 | protein kinase activator activity | 0.0471480208963674 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| pneumocyte | 2.39e-66 | 3 |
| epithelial cell of tracheobronchial tree | 2.62e-23 | 9 |
| epithelial cell of lower respiratory tract | 2.62e-23 | 9 |
| respiratory epithelial cell | 1.21e-16 | 13 |
| epithelial cell of lung | 6.95e-12 | 19 |
| Ontology term | p-value | n |
|---|---|---|
| bronchoalveolar duct junction | 1.55e-98 | 2 |
| alveolar duct | 1.55e-98 | 2 |
| bronchiole | 1.55e-98 | 2 |
| pulmonary alveolus epithelium | 2.39e-66 | 3 |
| alveolus | 2.39e-66 | 3 |
| pulmonary lobule | 2.39e-66 | 3 |
| lobule | 2.39e-66 | 3 |
| alveolus of lung | 2.39e-66 | 3 |
| alveolar system | 2.39e-66 | 3 |
| pulmonary acinus | 2.39e-66 | 3 |
| alveolar sac | 2.39e-66 | 3 |
| alveolar wall | 2.39e-66 | 3 |
| anatomical wall | 6.76e-18 | 12 |
| tracheobronchial tree | 1.22e-14 | 15 |
| lower respiratory tract | 1.22e-14 | 15 |
| duct | 6.95e-12 | 19 |
| respiratory tract epithelium | 6.95e-12 | 19 |
| lung epithelium | 6.95e-12 | 19 |
| lung | 1.80e-10 | 22 |
| simple squamous epithelium | 1.80e-10 | 22 |
| respiratory tube | 1.80e-10 | 22 |
| respiration organ | 1.80e-10 | 22 |
| pair of lungs | 1.80e-10 | 22 |
| lung primordium | 1.80e-10 | 22 |
| lung bud | 1.80e-10 | 22 |
| epithelial sac | 2.15e-09 | 25 |
| squamous epithelium | 2.15e-09 | 25 |
| sac | 4.34e-09 | 26 |
| respiratory system epithelium | 1.52e-08 | 28 |
| thoracic cavity element | 2.74e-07 | 34 |
| thoracic cavity | 2.74e-07 | 34 |
| thoracic segment organ | 4.03e-07 | 35 |
| epithelial bud | 8.21e-07 | 37 |
| Ontology term | p-value | n |
|---|---|---|
| lung adenocarcinoma | 1.55e-98 | 2 |
| non-small cell lung carcinoma | 1.48e-40 | 5 |
| bronchus cancer | 1.78e-29 | 7 |
| bronchogenic carcinoma | 1.78e-29 | 7 |
| lung carcinoma | 2.62e-23 | 9 |
| lung cancer | 1.22e-14 | 15 |
| respiratory system cancer | 8.02e-14 | 16 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| JUN#3725 | 16 | 3.08008103195971 | 3.99486758543661e-05 | 0.000741988219376515 |
| STAT3#6774 | 19 | 3.0749205376297 | 6.20075441492697e-06 | 0.000183196772373567 |
| TCF7L2#6934 | 19 | 3.14820545691707 | 4.39975432367538e-06 | 0.000137782891097551 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
