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Coexpression cluster:C2487

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Full id: C2487_Alveolar_Mesenchymal_Renal_Placental_Bronchial_acute_Tracheal



Phase1 CAGE Peaks

Hg19::chr19:39421556..39421632,+p1@MRPS12
Hg19::chr19:39971470..39971498,+p1@TIMM50
Hg19::chr1:26496382..26496457,+p1@ZNF593
Hg19::chr21:46359907..46359962,+p1@FAM207A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0044429mitochondrial part0.0469200548296613
GO:0005744mitochondrial inner membrane presequence translocase complex0.0469200548296613
GO:0043021ribonucleoprotein binding0.0469200548296613
GO:0007006mitochondrial membrane organization and biogenesis0.0469200548296613
GO:0031974membrane-enclosed lumen0.0469200548296613
GO:0043233organelle lumen0.0469200548296613
GO:0005739mitochondrion0.0469200548296613



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
mesenchyme1.99e-16238
entire embryonic mesenchyme1.99e-16238
trunk6.84e-15216
trunk mesenchyme8.45e-13143
unilaminar epithelium1.38e-11138
multilaminar epithelium9.60e-1182
epithelial tube1.59e-10118
dermomyotome6.49e-1070
somite8.58e-0983
paraxial mesoderm8.58e-0983
presomitic mesoderm8.58e-0983
presumptive segmental plate8.58e-0983
trunk paraxial mesoderm8.58e-0983
presumptive paraxial mesoderm8.58e-0983
subdivision of trunk1.18e-08113
trunk region element6.32e-08107
skeletal muscle tissue8.06e-0861
striated muscle tissue8.06e-0861
myotome8.06e-0861
cell layer9.97e-08312
nephron epithelium1.45e-0716
nephron1.45e-0716
uriniferous tubule1.45e-0716
metanephric mesenchyme1.45e-0716
nephrogenic mesenchyme1.45e-0716
epithelium2.09e-07309
cortex2.24e-0716
primordium4.56e-07168
muscle tissue6.96e-0763
musculature6.96e-0763
musculature of body6.96e-0763
multi-tissue structure8.07e-07347
Disease
Ontology termp-valuen
cancer2.76e-18235
disease of cellular proliferation3.71e-18239
cell type cancer1.70e-10143
organ system cancer2.17e-08137
hematologic cancer7.57e-0851
immune system cancer7.57e-0851
carcinoma9.84e-08106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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