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Coexpression cluster:C4652

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Full id: C4652_CD14_neuroectodermal_CD8_Neutrophils_CD4_Natural_anaplastic



Phase1 CAGE Peaks

Hg19::chr7:130604898..130604901,-p@chr7:130604898..130604901
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Hg19::chr7:130623634..130623638,-p@chr7:130623634..130623638
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Hg19::chr7:130625196..130625211,-p@chr7:130625196..130625211
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte4.00e-36136
nongranular leukocyte3.86e-33115
hematopoietic lineage restricted progenitor cell2.14e-29120
hematopoietic stem cell3.82e-25168
angioblastic mesenchymal cell3.82e-25168
hematopoietic oligopotent progenitor cell5.25e-24161
hematopoietic multipotent progenitor cell5.25e-24161
hematopoietic cell1.89e-23177
classical monocyte1.49e-1842
CD14-positive, CD16-negative classical monocyte1.49e-1842
lymphocyte2.73e-1753
common lymphoid progenitor2.73e-1753
myeloid leukocyte3.47e-1772
lymphoid lineage restricted progenitor cell3.71e-1752
defensive cell7.57e-1648
phagocyte7.57e-1648
nucleate cell1.90e-1555
monopoietic cell2.33e-1459
monocyte2.33e-1459
monoblast2.33e-1459
promonocyte2.33e-1459
macrophage dendritic cell progenitor2.51e-1461
granulocyte monocyte progenitor cell2.11e-1367
myeloid lineage restricted progenitor cell1.05e-1266
myeloid cell4.06e-09108
common myeloid progenitor4.06e-09108
mature alpha-beta T cell5.52e-0918
alpha-beta T cell5.52e-0918
immature T cell5.52e-0918
mature T cell5.52e-0918
immature alpha-beta T cell5.52e-0918
lymphocyte of B lineage1.15e-0824
pro-B cell1.15e-0824
T cell4.22e-0825
pro-T cell4.22e-0825
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.30e-1698
blood island8.30e-1698
hemolymphoid system6.53e-14108
adult organism3.55e-12114
bone marrow6.50e-1276
bone element7.46e-1182
immune system2.79e-1093
skeletal element7.37e-0890
skeletal system6.26e-07100
regional part of nervous system7.07e-0753
regional part of brain7.07e-0753
neural tube9.67e-0756
neural rod9.67e-0756
future spinal cord9.67e-0756
neural keel9.67e-0756


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.