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Coexpression cluster:C1163: Difference between revisions

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{{Coexpression_clusters
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|full_id=C1163_Eosinophils_Neutrophils_CD14_Basophils_CD14CD16_Peripheral_Whole
|id=C1163
|ontology_enrichment_celltype=CL:0000037!1.28e-40!172;CL:0000566!1.28e-40!172;CL:0002057!2.79e-39!42;CL:0000738!4.74e-39!140;CL:0000766!9.74e-38!76;CL:0000763!7.50e-37!112;CL:0000049!7.50e-37!112;CL:0000988!4.82e-36!182;CL:0002032!1.72e-35!165;CL:0000837!1.72e-35!165;CL:0000860!2.66e-35!45;CL:0000557!2.38e-32!71;CL:0002009!8.21e-30!65;CL:0000839!1.05e-28!70;CL:0002194!1.70e-28!63;CL:0000576!1.70e-28!63;CL:0000040!1.70e-28!63;CL:0000559!1.70e-28!63;CL:0002031!2.16e-27!124;CL:0002087!3.61e-27!119;CL:0000134!8.02e-13!358;CL:0000219!3.16e-12!390;CL:0002320!3.73e-12!365;CL:0002393!1.89e-10!9;CL:0002397!1.89e-10!9;CL:0000094!1.88e-09!8;CL:0000034!3.21e-07!444
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002390!1.45e-36!102;UBERON:0003061!1.45e-36!102;UBERON:0002193!2.49e-31!112;UBERON:0002371!1.10e-29!80;UBERON:0001474!1.46e-27!86;UBERON:0004765!5.32e-23!101;UBERON:0001434!5.32e-23!101;UBERON:0002405!8.64e-21!115;UBERON:0002384!6.58e-12!375;UBERON:0000178!3.73e-08!15;UBERON:0000179!3.73e-08!15;UBERON:0000463!3.73e-08!15;UBERON:0002204!1.05e-07!167;UBERON:0003081!1.38e-07!216
}}

Latest revision as of 11:39, 17 September 2013


Full id: C1163_Eosinophils_Neutrophils_CD14_Basophils_CD14CD16_Peripheral_Whole



Phase1 CAGE Peaks

Hg19::chr12:116971076..116971098,-p@chr12:116971076..116971098
-
Hg19::chr12:6248302..6248322,+p@chr12:6248302..6248322
+
Hg19::chr15:70046791..70046807,+p@chr15:70046791..70046807
+
Hg19::chr17:72524933..72524943,+p@chr17:72524933..72524943
+
Hg19::chr3:195627624..195627639,-p@chr3:195627624..195627639
-
Hg19::chr6:14728163..14728174,-p@chr6:14728163..14728174
-
Hg19::chr6:166755214..166755237,+p@chr6:166755214..166755237
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte6.61e-9642
CD14-positive, CD16-negative classical monocyte6.61e-9642
myeloid leukocyte4.54e-8472
defensive cell6.27e-8348
phagocyte6.27e-8348
monopoietic cell9.28e-6559
monocyte9.28e-6559
monoblast9.28e-6559
promonocyte9.28e-6559
macrophage dendritic cell progenitor2.05e-6261
myeloid lineage restricted progenitor cell8.13e-6166
granulocyte monocyte progenitor cell8.38e-6067
myeloid cell2.62e-53108
common myeloid progenitor2.62e-53108
leukocyte7.66e-53136
stuff accumulating cell3.36e-4287
nongranular leukocyte4.64e-41115
hematopoietic stem cell5.00e-41168
angioblastic mesenchymal cell5.00e-41168
hematopoietic cell1.81e-38177
hematopoietic oligopotent progenitor cell1.05e-36161
hematopoietic multipotent progenitor cell1.05e-36161
intermediate monocyte1.98e-369
CD14-positive, CD16-positive monocyte1.98e-369
hematopoietic lineage restricted progenitor cell3.41e-34120
granulocyte2.67e-258
blood cell4.07e-1811
mesenchymal cell1.91e-14354
connective tissue cell5.62e-14361
neutrophil1.11e-133
basophil4.15e-133
single nucleate cell5.98e-133
mononuclear cell5.98e-133
non-classical monocyte1.05e-123
CD14-low, CD16-positive monocyte1.05e-123
motile cell2.53e-12386
stem cell1.95e-10441
multi fate stem cell2.65e-10427
somatic stem cell5.04e-10433
Uber Anatomy
Ontology termp-valuen
hematopoietic system9.88e-5998
blood island9.88e-5998
hemolymphoid system1.64e-52108
bone marrow7.24e-5276
bone element1.56e-4782
skeletal element1.22e-4290
immune system5.06e-4193
skeletal system1.28e-37100
lateral plate mesoderm8.19e-24203
musculoskeletal system2.07e-19167
connective tissue2.45e-13371
mesoderm3.83e-12315
mesoderm-derived structure3.83e-12315
presumptive mesoderm3.83e-12315
blood4.61e-1215
haemolymphatic fluid4.61e-1215
organism substance4.61e-1215


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00215847
MA0004.10.502801
MA0006.10.341337
MA0007.10.483857
MA0009.10.973289
MA0014.10.0723474
MA0017.10.380797
MA0019.11.57204
MA0024.10.867125
MA0025.12.50576
MA0027.12.59001
MA0028.10.35747
MA0029.10.886702
MA0030.10.875089
MA0031.10.809638
MA0038.10.60704
MA0040.10.892629
MA0041.10.521615
MA0042.10.48922
MA0043.10.973609
MA0046.10.962263
MA0048.10.382278
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.10.0407081
MA0056.10
MA0057.10.115382
MA0058.10.406232
MA0059.10.404929
MA0060.10.638423
MA0061.10.198335
MA0063.10
MA0066.10.607474
MA0067.11.29359
MA0068.10.162298
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.10.0282921
MA0074.10.60198
MA0076.10.422297
MA0077.10.934645
MA0078.10.703614
MA0081.10.405093
MA0083.10.980893
MA0084.11.48179
MA0087.10.939982
MA0088.10.0723293
MA0089.10
MA0090.10.436918
MA0091.10.505453
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.10.621149
MA0101.10.347695
MA0103.10.332048
MA0105.10.104569
MA0106.10.648997
MA0107.10.274127
MA0108.20.806528
MA0109.10
MA0111.11.14351
MA0113.10.665691
MA0114.10.269076
MA0115.11.21667
MA0116.10.277571
MA0117.11.01134
MA0119.10.388712
MA0122.11.03753
MA0124.11.17486
MA0125.11.0901
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.186511
MA0140.10.564957
MA0141.10.403171
MA0142.10.777365
MA0143.10.66587
MA0144.10.254954
MA0145.10.0807715
MA0146.10.0610556
MA0147.10.281049
MA0148.10.528066
MA0149.10.555119
MA0062.20.193221
MA0035.20.564239
MA0039.20.403603
MA0138.20.704862
MA0002.20.611548
MA0137.20.36398
MA0104.20.223944
MA0047.20.636643
MA0112.20.262665
MA0065.20.0828768
MA0150.10.430951
MA0151.10
MA0152.10.571637
MA0153.11.07307
MA0154.10.102476
MA0155.10.250175
MA0156.10.36627
MA0157.10.749547
MA0158.10
MA0159.11.40717
MA0160.10.543522
MA0161.10
MA0162.10.0249953
MA0163.10.632664
MA0164.10.678332
MA0080.20.911393
MA0018.20.650405
MA0099.20.572
MA0079.20.0232399
MA0102.21.51913
MA0258.11.27333
MA0259.10.289405
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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