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{{Coexpression_clusters
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|full_id=C2706_amniotic_Small_Amniotic_Placental_mesothelioma_papillotubular_Smooth
|id=C2706
|ontology_enrichment_celltype=CL:0000220!3.14e-19!246;CL:0002321!1.32e-18!248;CL:0000066!9.87e-16!254;CL:0000222!1.17e-12!119;CL:0000076!5.32e-10!62;CL:0000055!2.04e-09!180;CL:0000213!3.56e-08!57;CL:0000215!3.56e-08!57
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000483!1.23e-19!309;UBERON:0000119!3.60e-19!312;UBERON:0004111!2.29e-17!241;UBERON:0000025!2.40e-16!194;UBERON:0000468!1.35e-15!659;UBERON:0004872!5.13e-15!84;UBERON:0000477!1.18e-14!286;UBERON:0000475!1.41e-14!365;UBERON:0002049!3.33e-14!79;UBERON:0007798!3.33e-14!79;UBERON:0000467!3.48e-14!625;UBERON:0000481!3.80e-14!347;UBERON:0003914!4.64e-14!118;UBERON:0000480!7.96e-14!626;UBERON:0001981!8.93e-14!60;UBERON:0007500!8.93e-14!60;UBERON:0004537!8.93e-14!60;UBERON:0006965!8.93e-14!60;UBERON:0000055!1.47e-13!69;UBERON:0001637!3.19e-11!42;UBERON:0003509!3.19e-11!42;UBERON:0004572!3.19e-11!42;UBERON:0004535!8.14e-11!110;UBERON:0002050!8.40e-11!605;UBERON:0005423!8.40e-11!605;UBERON:0000923!1.26e-10!604;UBERON:0005291!1.26e-10!604;UBERON:0006598!1.26e-10!604;UBERON:0002532!1.26e-10!604;UBERON:0001009!1.69e-10!113;UBERON:0000922!4.46e-10!612;UBERON:0004573!6.43e-10!33;UBERON:0004571!6.43e-10!33;UBERON:0000064!1.23e-09!219;UBERON:0002100!1.66e-08!216;UBERON:0004121!6.91e-08!169;UBERON:0000924!2.43e-07!173;UBERON:0006601!2.43e-07!173;UBERON:0003104!6.80e-07!238;UBERON:0009142!6.80e-07!238
}}

Latest revision as of 12:11, 17 September 2013


Full id: C2706_amniotic_Small_Amniotic_Placental_mesothelioma_papillotubular_Smooth



Phase1 CAGE Peaks

Hg19::chr2:9346892..9346948,+p1@ASAP2
Hg19::chr2:9346949..9346975,+p2@ASAP2
Hg19::chr2:9346976..9346986,+p3@ASAP2
Hg19::chr2:9347003..9347010,+p4@ASAP2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
embryonic cell8.32e-18250
epithelial cell9.04e-16253
mesodermal cell5.00e-12121
squamous epithelial cell2.67e-0963
extraembryonic cell1.01e-0719
lining cell2.17e-0758
barrier cell2.17e-0758
vascular associated smooth muscle cell8.54e-0732
Uber Anatomy
Ontology termp-valuen
epithelium1.24e-18306
cell layer2.72e-18309
anatomical conduit7.31e-17240
tube4.59e-16192
anatomical cluster4.98e-16373
multi-cellular organism2.57e-15656
splanchnic layer of lateral plate mesoderm2.49e-1483
epithelial tube4.39e-14117
anatomical system1.52e-13624
anatomical group3.32e-13625
vasculature4.08e-1378
vascular system4.08e-1378
multi-tissue structure5.81e-13342
epithelial tube open at both ends8.31e-1359
blood vessel8.31e-1359
blood vasculature8.31e-1359
vascular cord8.31e-1359
vessel1.98e-1268
artery2.84e-1142
arterial blood vessel2.84e-1142
arterial system2.84e-1142
embryo7.53e-10592
systemic artery8.95e-1033
systemic arterial system8.95e-1033
cardiovascular system9.04e-10109
circulatory system1.66e-09112
organ part3.20e-09218
developing anatomical structure3.32e-09581
trunk1.57e-08199
organism subdivision1.78e-08264
embryonic structure1.98e-08564
germ layer4.71e-08560
germ layer / neural crest4.71e-08560
embryonic tissue4.71e-08560
presumptive structure4.71e-08560
germ layer / neural crest derived structure4.71e-08560
epiblast (generic)4.71e-08560
structure with developmental contribution from neural crest8.57e-08132
mesenchyme9.69e-08160
entire embryonic mesenchyme9.69e-08160
unilaminar epithelium4.74e-07148
ectoderm-derived structure9.43e-07171
ectoderm9.43e-07171
presumptive ectoderm9.43e-07171


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.120.2533
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.18.67501
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.12.82503
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.12.70115
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.11.18043
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.12.13662
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.11.63368
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.11.70272
MA0146.15.02892
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.26.36864
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.21.01696
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.12.30186
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.12.15942
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.24.43857
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186944.907389214879320.001724022357361790.0106636168777322
E2F6#187645.017155731697390.00157802193473060.00998165058696196
EGR1#195844.988179094810140.001615011500076050.0101571833106373
GABPB1#255347.067683836182170.0004006876864423170.00390695745349165
HMGN3#932436.133910792512940.006640696683324720.0283069148569344
TAF1#687243.343046285745290.008005664898701650.0322807473207792
TFAP2C#7022410.80922860986027.32289634782688e-050.001147136600676



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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