MCL coexpression mm9:26: Difference between revisions
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|ontology_enrichment_uberon=UBERON:0002394!3.07e-86!1;UBERON:0001281!3.07e-86!1;UBERON:0000353!3.07e-86!1;UBERON:0003497!3.07e-86!1;UBERON:0003909!3.07e-86!1;UBERON:0003928!3.07e-86!1;UBERON:0003835!3.07e-86!1;UBERON:0003513!3.07e-86!1;UBERON:0001280!3.07e-86!1;UBERON:0004647!3.07e-86!1;UBERON:0002294!3.07e-86!1;UBERON:0001173!3.07e-86!1;UBERON:0004912!3.07e-86!1;UBERON:0005171!3.07e-86!1;UBERON:0000055!1.16e-18!5;UBERON:0007500!1.16e-18!5;UBERON:0001981!1.16e-18!5;UBERON:0002049!1.16e-18!5;UBERON:0007798!1.16e-18!5;UBERON:0004537!1.16e-18!5;UBERON:0006965!1.16e-18!5;UBERON:0000058!8.67e-14!7 | |ontology_enrichment_uberon=UBERON:0002394!3.07e-86!1;UBERON:0001281!3.07e-86!1;UBERON:0000353!3.07e-86!1;UBERON:0003497!3.07e-86!1;UBERON:0003909!3.07e-86!1;UBERON:0003928!3.07e-86!1;UBERON:0003835!3.07e-86!1;UBERON:0003513!3.07e-86!1;UBERON:0001280!3.07e-86!1;UBERON:0004647!3.07e-86!1;UBERON:0002294!3.07e-86!1;UBERON:0001173!3.07e-86!1;UBERON:0004912!3.07e-86!1;UBERON:0005171!3.07e-86!1;UBERON:0000055!1.16e-18!5;UBERON:0007500!1.16e-18!5;UBERON:0001981!1.16e-18!5;UBERON:0002049!1.16e-18!5;UBERON:0007798!1.16e-18!5;UBERON:0004537!1.16e-18!5;UBERON:0006965!1.16e-18!5;UBERON:0000058!8.67e-14!7 | ||
|tfbs_overrepresentation_for_novel_motifs=0.0727436,0.142756,0.0335635,0.881449,0.861832,0.567236,0.12842,0.0359062,1.04906,0.00232189,0.0529019,0.419673,0.000121431,0.365283,0.744122,0,0.0203986,0.0629988,0.391696,0.213075,0.201669,0.609053,3.26985e-05,0.232292,0.183468,0.000930157,0.253235,0.0276745,0.111618,0.356281,0.12744,0.234076,0.0576103,0.0867516,0.149894,0.00174057,1.01528e-07,0.002098,1.18523,0.0124561,0.628164,0.242485,1.50182,0.156899,0.0562378,0.0176485,0.0616054,0.0415895,0.470564,0.399437,0.095861,0.18998,0.520554,0.193512,0.355856,0.177551,0.156659,0.158235,0.308905,0.0557788,0.289036,0.154805,0.337693,0.195322,0.0017554,0.416343,0.178407,0.85302,1.34562,0.274192,0.00426529,1.81686,7.10555e-07,0.441287,0.00287106,0.0176936,0.26506,0.185053,0.353697,1.90653,0.423593,0.0273034,0.151528,1.03026,0.0077003,7.25841e-10,0.00151293,0.318118,0.159419,0.404359,0.469031,0.310993,0.169237,0.063391,0.000164468,0.83294,2.58445,0.391837,0.21507,0.280357,0.279756,0.830433,0.277539,0.224044,0.149638,0.000428521,0.0398056,0.514199,0.073274,0.000295657,1.0441,0.170166,1.06642,0.286311,0.48518,1.40899,2.41705e-08,0.401497,0.0416081,0.250777,0.0847333,0.0978717,0.181951,0.570226,0.190764,0.500072,1.08691,0.00829171,0.176615,0.422166,0.243352,0.0308668,0.439562,1.17526,0.317168,0.471737,1.41476,0.79729,0.423549,0.939809,0.114206,0.184041,1.03395,0.257638,0.0272807,0.105088,0.659582,0.875355,1.45277,0.00183445,0.0958769,2.54582e-14,0.0501579,0.428982,1.16568,0.206564,0.136293,1.81248,0.123822,0.0131479,0.444337,0.808148,0.84441,0.177413,1.18648,0.784425,0.560995,1.35286,0.000250692 | |tfbs_overrepresentation_for_novel_motifs=0.0727436,0.142756,0.0335635,0.881449,0.861832,0.567236,0.12842,0.0359062,1.04906,0.00232189,0.0529019,0.419673,0.000121431,0.365283,0.744122,0,0.0203986,0.0629988,0.391696,0.213075,0.201669,0.609053,3.26985e-05,0.232292,0.183468,0.000930157,0.253235,0.0276745,0.111618,0.356281,0.12744,0.234076,0.0576103,0.0867516,0.149894,0.00174057,1.01528e-07,0.002098,1.18523,0.0124561,0.628164,0.242485,1.50182,0.156899,0.0562378,0.0176485,0.0616054,0.0415895,0.470564,0.399437,0.095861,0.18998,0.520554,0.193512,0.355856,0.177551,0.156659,0.158235,0.308905,0.0557788,0.289036,0.154805,0.337693,0.195322,0.0017554,0.416343,0.178407,0.85302,1.34562,0.274192,0.00426529,1.81686,7.10555e-07,0.441287,0.00287106,0.0176936,0.26506,0.185053,0.353697,1.90653,0.423593,0.0273034,0.151528,1.03026,0.0077003,7.25841e-10,0.00151293,0.318118,0.159419,0.404359,0.469031,0.310993,0.169237,0.063391,0.000164468,0.83294,2.58445,0.391837,0.21507,0.280357,0.279756,0.830433,0.277539,0.224044,0.149638,0.000428521,0.0398056,0.514199,0.073274,0.000295657,1.0441,0.170166,1.06642,0.286311,0.48518,1.40899,2.41705e-08,0.401497,0.0416081,0.250777,0.0847333,0.0978717,0.181951,0.570226,0.190764,0.500072,1.08691,0.00829171,0.176615,0.422166,0.243352,0.0308668,0.439562,1.17526,0.317168,0.471737,1.41476,0.79729,0.423549,0.939809,0.114206,0.184041,1.03395,0.257638,0.0272807,0.105088,0.659582,0.875355,1.45277,0.00183445,0.0958769,2.54582e-14,0.0501579,0.428982,1.16568,0.206564,0.136293,1.81248,0.123822,0.0131479,0.444337,0.808148,0.84441,0.177413,1.18648,0.784425,0.560995,1.35286,0.000250692 | ||
|tfbs_overrepresentation_jaspar=MA0003.1;4.22874e-09,MA0004.1;1.15872,MA0006.1;0.0122016,MA0007.1;0.527564,MA0009.1;1.77136,MA0014.1;4.50362e-07,MA0017.1;0.447274,MA0019.1;0.206472,MA0024.1;0.123358,MA0025.1;0.139167,MA0027.1;0.776932,MA0028.1;0.00926579,MA0029.1;0.347886,MA0030.1;1.28519,MA0031.1;1.24325,MA0038.1;0.31701,MA0040.1;0.637224,MA0041.1;0.0992341,MA0042.1;0.0914232,MA0043.1;0.275446,MA0046.1;0.0463969,MA0048.1;0.00046392,MA0050.1;3.28448,MA0051.1;4.22271,MA0052.1;3.82798,MA0055.1;2.76134e-07,MA0056.1;0,MA0057.1;0.612954,MA0058.1;1.86645,MA0059.1;0.638288,MA0060.1;0.010142,MA0061.1;8.51295,MA0063.1;0,MA0066.1;0.104095,MA0067.1;0.482241,MA0068.1;1.39627,MA0069.1;0.233428,MA0070.1;0.130299,MA0071.1;1.04198,MA0072.1;0.303114,MA0073.1;0.0035717,MA0074.1;0.0326913,MA0076.1;0.0294112,MA0077.1;0.250845,MA0078.1;0.408698,MA0081.1;1.93413,MA0083.1;0.802421,MA0084.1;0.28215,MA0087.1;0.822123,MA0088.1;0.119159,MA0089.1;0,MA0090.1;1.41452,MA0091.1;0.310085,MA0092.1;0.554162,MA0093.1;2.18569,MA0095.1;0,MA0098.1;0,MA0100.1;0.0247187,MA0101.1;7.24012,MA0103.1;0.00134689,MA0105.1;0.992065,MA0106.1;0.696422,MA0107.1;10.5762,MA0108.2;4.41412,MA0109.1;0,MA0111.1;0.332825,MA0113.1;0.522151,MA0114.1;0.143342,MA0115.1;0.0149828,MA0116.1;0.0610331,MA0117.1;0.0287108,MA0119.1;1.21985,MA0122.1;0.76293,MA0124.1;0.095649,MA0125.1;0.123226,MA0130.1;0,MA0131.1;0.0142431,MA0132.1;0,MA0133.1;0,MA0135.1;0.222613,MA0136.1;4.65964,MA0139.1;0.000134045,MA0140.1;1.29012,MA0141.1;0.892772,MA0142.1;0.00487565,MA0143.1;0.0252132,MA0144.1;31.9171,MA0145.1;0.461201,MA0146.1;0.000193608,MA0147.1;0.0159017,MA0148.1;1.72819,MA0149.1;14.6917,MA0062.2;0.0748421,MA0035.2;2.62143,MA0039.2;0.000465635,MA0138.2;0.118758,MA0002.2;0.283485,MA0137.2;32.1372,MA0104.2;0.072169,MA0047.2;2.06825,MA0112.2;0.114748,MA0065.2;0.316803,MA0150.1;0.728496,MA0151.1;0,MA0152.1;0.507689,MA0153.1;0.0695438,MA0154.1;0.300208,MA0155.1;0.00948095,MA0156.1;6.90653,MA0157.1;0.727477,MA0158.1;0,MA0159.1;1.99004,MA0160.1;0.719232,MA0161.1;0,MA0162.1;4.04245e-07,MA0163.1;0.0274928,MA0164.1;0.0511113,MA0080.2;8.0155,MA0018.2;0.418188,MA0099.2;1.40513,MA0079.2;2.00188e-06,MA0102.2;0.691473,MA0258.1;0.408585,MA0259.1;0.0241469,MA0442.1;0 | |||
}} | }} |
Revision as of 11:01, 23 January 2013
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0032502 | developmental process | 0.000252198134104392 |
GO:0006950 | response to stress | 0.000479935166683036 |
GO:0048523 | negative regulation of cellular process | 0.00101020896255446 |
GO:0009887 | organ morphogenesis | 0.00110729685206789 |
GO:0048519 | negative regulation of biological process | 0.00110729685206789 |
GO:0048856 | anatomical structure development | 0.00110729685206789 |
GO:0030336 | negative regulation of cell migration | 0.00149530458123058 |
GO:0007275 | multicellular organismal development | 0.00153235395154225 |
GO:0009653 | anatomical structure morphogenesis | 0.00188251691041489 |
GO:0048514 | blood vessel morphogenesis | 0.00211188504987544 |
GO:0051271 | negative regulation of cell motility | 0.00211188504987544 |
GO:0040013 | negative regulation of locomotion | 0.00229312271233903 |
GO:0065007 | biological regulation | 0.00371517193809661 |
GO:0001568 | blood vessel development | 0.00395644696487096 |
GO:0001944 | vasculature development | 0.00400405187010283 |
GO:0050789 | regulation of biological process | 0.00442951576169606 |
GO:0001525 | angiogenesis | 0.00466865319844725 |
GO:0048731 | system development | 0.00472704399680285 |
GO:0050794 | regulation of cellular process | 0.00520800907249799 |
GO:0009408 | response to heat | 0.00560817390831012 |
GO:0042060 | wound healing | 0.00580492059428471 |
GO:0048869 | cellular developmental process | 0.00582491384452112 |
GO:0030154 | cell differentiation | 0.00582491384452112 |
GO:0006468 | protein amino acid phosphorylation | 0.00627940931496878 |
GO:0032555 | purine ribonucleotide binding | 0.00838848788160829 |
GO:0032553 | ribonucleotide binding | 0.00838848788160829 |
GO:0016310 | phosphorylation | 0.01252958406668 |
GO:0048646 | anatomical structure formation | 0.01252958406668 |
GO:0005021 | vascular endothelial growth factor receptor activity | 0.0129978081497608 |
GO:0017076 | purine nucleotide binding | 0.0129978081497608 |
GO:0009266 | response to temperature stimulus | 0.0129978081497608 |
GO:0048513 | organ development | 0.0130394936033132 |
GO:0042246 | tissue regeneration | 0.0137922486352231 |
GO:0031099 | regeneration | 0.0137922486352231 |
GO:0000166 | nucleotide binding | 0.0154304620221803 |
GO:0030334 | regulation of cell migration | 0.0160526620935058 |
GO:0051270 | regulation of cell motility | 0.0225776679712753 |
GO:0044421 | extracellular region part | 0.0240864681369983 |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 0.0240864681369983 |
GO:0051726 | regulation of cell cycle | 0.0240864681369983 |
GO:0040012 | regulation of locomotion | 0.0240864681369983 |
GO:0016525 | negative regulation of angiogenesis | 0.0240864681369983 |
GO:0006793 | phosphorus metabolic process | 0.0248680046717384 |
GO:0006796 | phosphate metabolic process | 0.0248680046717384 |
GO:0000723 | telomere maintenance | 0.0248680046717384 |
GO:0032200 | telomere organization and biogenesis | 0.0248680046717384 |
GO:0050878 | regulation of body fluid levels | 0.0291196867049982 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0314995540119739 |
GO:0019199 | transmembrane receptor protein kinase activity | 0.0314995540119739 |
GO:0004713 | protein-tyrosine kinase activity | 0.032238911915182 |
GO:0001889 | liver development | 0.0343230747823438 |
GO:0007157 | heterophilic cell adhesion | 0.0352039167155702 |
GO:0005654 | nucleoplasm | 0.0352039167155702 |
GO:0009888 | tissue development | 0.0352039167155702 |
GO:0022402 | cell cycle process | 0.0352039167155702 |
GO:0001709 | cell fate determination | 0.0352039167155702 |
GO:0005667 | transcription factor complex | 0.0352039167155702 |
GO:0009611 | response to wounding | 0.0352039167155702 |
GO:0005524 | ATP binding | 0.0352039167155702 |
GO:0035026 | leading edge cell differentiation | 0.0352039167155702 |
GO:0031583 | G-protein signaling, phospholipase D activating pathway | 0.0352039167155702 |
GO:0001887 | selenium metabolic process | 0.0352039167155702 |
GO:0031953 | negative regulation of protein amino acid autophosphorylation | 0.0352039167155702 |
GO:0046108 | uridine metabolic process | 0.0352039167155702 |
GO:0008665 | 2'-phosphotransferase activity | 0.0352039167155702 |
GO:0031705 | bombesin receptor binding | 0.0352039167155702 |
GO:0031952 | regulation of protein amino acid autophosphorylation | 0.0352039167155702 |
GO:0015559 | multidrug efflux pump activity | 0.0352039167155702 |
GO:0045844 | positive regulation of striated muscle development | 0.0352039167155702 |
GO:0031707 | endothelin A receptor binding | 0.0352039167155702 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.0352039167155702 |
GO:0004672 | protein kinase activity | 0.0352039167155702 |
GO:0031324 | negative regulation of cellular metabolic process | 0.0352039167155702 |
GO:0032559 | adenyl ribonucleotide binding | 0.0366739495243474 |
GO:0015758 | glucose transport | 0.0379798875899485 |
GO:0006953 | acute-phase response | 0.0379798875899485 |
GO:0008645 | hexose transport | 0.0395901316681585 |
GO:0015749 | monosaccharide transport | 0.0395901316681585 |
GO:0022610 | biological adhesion | 0.0395901316681585 |
GO:0007155 | cell adhesion | 0.0395901316681585 |
GO:0045765 | regulation of angiogenesis | 0.0438661192666025 |
GO:0030554 | adenyl nucleotide binding | 0.0476840965503713 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
lining cell | 3.07e-86 | 1 |
meso-epithelial cell | 3.07e-86 | 1 |
endothelial cell | 3.07e-86 | 1 |
endothelial cell of sinusoid | 3.07e-86 | 1 |
endothelial cell of hepatic sinusoid | 3.07e-86 | 1 |
barrier cell | 5.61e-30 | 3 |
metabolising cell | 1.16e-18 | 5 |
endopolyploid cell | 1.16e-18 | 5 |
parenchymal cell | 1.16e-18 | 5 |
polyploid cell | 1.16e-18 | 5 |
hepatocyte | 1.16e-18 | 5 |
mesodermal cell | 8.67e-14 | 7 |
Ontology term | p-value | n |
---|---|---|
bile duct | 3.07e-86 | 1 |
hepatic sinusoid | 3.07e-86 | 1 |
parenchyma | 3.07e-86 | 1 |
abdomen blood vessel | 3.07e-86 | 1 |
sinusoid | 3.07e-86 | 1 |
digestive system duct | 3.07e-86 | 1 |
abdominal segment blood vessel | 3.07e-86 | 1 |
trunk blood vessel | 3.07e-86 | 1 |
liver parenchyma | 3.07e-86 | 1 |
liver lobule | 3.07e-86 | 1 |
biliary system | 3.07e-86 | 1 |
biliary tree | 3.07e-86 | 1 |
biliary bud | 3.07e-86 | 1 |
hepatic duct | 3.07e-86 | 1 |
vessel | 1.16e-18 | 5 |
epithelial tube open at both ends | 1.16e-18 | 5 |
blood vessel | 1.16e-18 | 5 |
vasculature | 1.16e-18 | 5 |
vascular system | 1.16e-18 | 5 |
blood vasculature | 1.16e-18 | 5 |
vascular cord | 1.16e-18 | 5 |
duct | 8.67e-14 | 7 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 4.22874e-09 |
MA0004.1 | 1.15872 |
MA0006.1 | 0.0122016 |
MA0007.1 | 0.527564 |
MA0009.1 | 1.77136 |
MA0014.1 | 4.50362e-07 |
MA0017.1 | 0.447274 |
MA0019.1 | 0.206472 |
MA0024.1 | 0.123358 |
MA0025.1 | 0.139167 |
MA0027.1 | 0.776932 |
MA0028.1 | 0.00926579 |
MA0029.1 | 0.347886 |
MA0030.1 | 1.28519 |
MA0031.1 | 1.24325 |
MA0038.1 | 0.31701 |
MA0040.1 | 0.637224 |
MA0041.1 | 0.0992341 |
MA0042.1 | 0.0914232 |
MA0043.1 | 0.275446 |
MA0046.1 | 0.0463969 |
MA0048.1 | 0.00046392 |
MA0050.1 | 3.28448 |
MA0051.1 | 4.22271 |
MA0052.1 | 3.82798 |
MA0055.1 | 2.76134e-07 |
MA0056.1 | 0 |
MA0057.1 | 0.612954 |
MA0058.1 | 1.86645 |
MA0059.1 | 0.638288 |
MA0060.1 | 0.010142 |
MA0061.1 | 8.51295 |
MA0063.1 | 0 |
MA0066.1 | 0.104095 |
MA0067.1 | 0.482241 |
MA0068.1 | 1.39627 |
MA0069.1 | 0.233428 |
MA0070.1 | 0.130299 |
MA0071.1 | 1.04198 |
MA0072.1 | 0.303114 |
MA0073.1 | 0.0035717 |
MA0074.1 | 0.0326913 |
MA0076.1 | 0.0294112 |
MA0077.1 | 0.250845 |
MA0078.1 | 0.408698 |
MA0081.1 | 1.93413 |
MA0083.1 | 0.802421 |
MA0084.1 | 0.28215 |
MA0087.1 | 0.822123 |
MA0088.1 | 0.119159 |
MA0089.1 | 0 |
MA0090.1 | 1.41452 |
MA0091.1 | 0.310085 |
MA0092.1 | 0.554162 |
MA0093.1 | 2.18569 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0247187 |
MA0101.1 | 7.24012 |
MA0103.1 | 0.00134689 |
MA0105.1 | 0.992065 |
MA0106.1 | 0.696422 |
MA0107.1 | 10.5762 |
MA0108.2 | 4.41412 |
MA0109.1 | 0 |
MA0111.1 | 0.332825 |
MA0113.1 | 0.522151 |
MA0114.1 | 0.143342 |
MA0115.1 | 0.0149828 |
MA0116.1 | 0.0610331 |
MA0117.1 | 0.0287108 |
MA0119.1 | 1.21985 |
MA0122.1 | 0.76293 |
MA0124.1 | 0.095649 |
MA0125.1 | 0.123226 |
MA0130.1 | 0 |
MA0131.1 | 0.0142431 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.222613 |
MA0136.1 | 4.65964 |
MA0139.1 | 0.000134045 |
MA0140.1 | 1.29012 |
MA0141.1 | 0.892772 |
MA0142.1 | 0.00487565 |
MA0143.1 | 0.0252132 |
MA0144.1 | 31.9171 |
MA0145.1 | 0.461201 |
MA0146.1 | 0.000193608 |
MA0147.1 | 0.0159017 |
MA0148.1 | 1.72819 |
MA0149.1 | 14.6917 |
MA0062.2 | 0.0748421 |
MA0035.2 | 2.62143 |
MA0039.2 | 0.000465635 |
MA0138.2 | 0.118758 |
MA0002.2 | 0.283485 |
MA0137.2 | 32.1372 |
MA0104.2 | 0.072169 |
MA0047.2 | 2.06825 |
MA0112.2 | 0.114748 |
MA0065.2 | 0.316803 |
MA0150.1 | 0.728496 |
MA0151.1 | 0 |
MA0152.1 | 0.507689 |
MA0153.1 | 0.0695438 |
MA0154.1 | 0.300208 |
MA0155.1 | 0.00948095 |
MA0156.1 | 6.90653 |
MA0157.1 | 0.727477 |
MA0158.1 | 0 |
MA0159.1 | 1.99004 |
MA0160.1 | 0.719232 |
MA0161.1 | 0 |
MA0162.1 | 4.04245e-07 |
MA0163.1 | 0.0274928 |
MA0164.1 | 0.0511113 |
MA0080.2 | 8.0155 |
MA0018.2 | 0.418188 |
MA0099.2 | 1.40513 |
MA0079.2 | 2.00188e-06 |
MA0102.2 | 0.691473 |
MA0258.1 | 0.408585 |
MA0259.1 | 0.0241469 |
MA0442.1 | 0 |