Coexpression cluster:C2301

Full id: C2301_CD14CD16_CD14_migratory_Dendritic_Basophils_Macrophage_myeloma

Phase1 CAGE Peaks

Hg19::chr14:55243185..55243200,+	p16@SAMD4A
Hg19::chr1:40810464..40810514,+	p2@SMAP2
Hg19::chr1:40810516..40810538,+	p5@SMAP2
Hg19::chr1:40811665..40811670,+	p@chr1:40811665..40811670 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030371	translation repressor activity	0.00618156128576475
GO:0045727	positive regulation of translation	0.0150123631225715
GO:0031328	positive regulation of cellular biosynthetic process	0.0150123631225715
GO:0009891	positive regulation of biosynthetic process	0.0150123631225715
GO:0051247	positive regulation of protein metabolic process	0.0150123631225715
GO:0006417	regulation of translation	0.0239535499823384
GO:0031326	regulation of cellular biosynthetic process	0.0239535499823384
GO:0009889	regulation of biosynthetic process	0.0239535499823384
GO:0031325	positive regulation of cellular metabolic process	0.0338781670466587
GO:0009893	positive regulation of metabolic process	0.0338781670466587
GO:0051246	regulation of protein metabolic process	0.0338781670466587

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
monopoietic cell	3.42e-52	59
monocyte	3.42e-52	59
monoblast	3.42e-52	59
promonocyte	3.42e-52	59
macrophage dendritic cell progenitor	1.08e-51	61
defensive cell	2.70e-51	48
phagocyte	2.70e-51	48
nongranular leukocyte	2.43e-48	115
leukocyte	1.01e-47	136
myeloid leukocyte	1.93e-46	72
granulocyte monocyte progenitor cell	4.69e-45	67
classical monocyte	5.32e-45	42
CD14-positive, CD16-negative classical monocyte	5.32e-45	42
myeloid lineage restricted progenitor cell	2.60e-44	66
hematopoietic lineage restricted progenitor cell	8.28e-42	120
hematopoietic stem cell	1.87e-32	168
angioblastic mesenchymal cell	1.87e-32	168
hematopoietic cell	9.96e-32	177
hematopoietic oligopotent progenitor cell	1.06e-31	161
hematopoietic multipotent progenitor cell	1.06e-31	161
myeloid cell	2.29e-28	108
common myeloid progenitor	2.29e-28	108
stuff accumulating cell	1.13e-19	87
intermediate monocyte	1.35e-11	9
CD14-positive, CD16-positive monocyte	1.35e-11	9
conventional dendritic cell	4.42e-08	8
macrophage	1.59e-07	6

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	8.79e-51	98
blood island	8.79e-51	98
hemolymphoid system	1.14e-46	108
bone marrow	7.27e-39	76
immune system	1.59e-34	93
bone element	2.14e-34	82
skeletal element	2.10e-29	90
skeletal system	2.09e-25	100
adult organism	1.36e-24	114
lateral plate mesoderm	3.05e-20	203
blood	1.62e-13	15
haemolymphatic fluid	1.62e-13	15
organism substance	1.62e-13	15
musculoskeletal system	3.73e-13	167
mesoderm	1.92e-09	315
mesoderm-derived structure	1.92e-09	315
presumptive mesoderm	1.92e-09	315
tissue	1.96e-07	773

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.