MCL coexpression mm9:1148

Phase1 CAGE Peaks

	Short description
Mm9::chr16:49855630..49855685,-	p@chr16:49855630..49855685 -
Mm9::chr18:32557234..32557249,+	p@chr18:32557234..32557249 +
Mm9::chr19:4154620..4154629,+	p2@Ptprcap
Mm9::chr19:4154640..4154668,+	p1@Ptprcap
Mm9::chr19:4156100..4156111,+	p@chr19:4156100..4156111 +
Mm9::chr19:46114855..46114867,-	p@chr19:46114855..46114867 -
Mm9::chr2:79095076..79095083,+	p12@Itga4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001968	fibronectin binding	0.0131481633363305
GO:0007159	leukocyte adhesion	0.0289101108018125
GO:0001974	blood vessel remodeling	0.0289101108018125
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	0.0289101108018125
GO:0007157	heterophilic cell adhesion	0.0289101108018125
GO:0008305	integrin complex	0.0372204718592457

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	8.25e-16	32
hematopoietic oligopotent progenitor cell	8.25e-16	32
hematopoietic stem cell	8.25e-16	32
angioblastic mesenchymal cell	8.25e-16	32
hematopoietic multipotent progenitor cell	8.25e-16	32
lymphoid lineage restricted progenitor cell	5.58e-14	12
T cell	6.49e-13	11
pro-T cell	6.49e-13	11
lymphocyte	1.50e-12	13
common lymphoid progenitor	1.50e-12	13
hematopoietic lineage restricted progenitor cell	5.03e-12	25
nucleate cell	6.92e-11	16
mature alpha-beta T cell	8.56e-11	9
alpha-beta T cell	8.56e-11	9
immature T cell	8.56e-11	9
mature T cell	8.56e-11	9
immature alpha-beta T cell	8.56e-11	9
CD4-positive, alpha-beta T cell	9.01e-10	8
connective tissue cell	3.28e-09	46
mesenchymal cell	3.28e-09	46
leukocyte	1.43e-08	17
nongranular leukocyte	1.43e-08	17
thymocyte	1.51e-07	6
double negative thymocyte	1.51e-07	6
naive T cell	1.51e-07	6
double-positive, alpha-beta thymocyte	1.51e-07	6
CD4-positive, alpha-beta thymocyte	1.51e-07	6
naive thymus-derived CD4-positive, alpha-beta T cell	1.51e-07	6
DN4 thymocyte	1.51e-07	6
DN1 thymic pro-T cell	1.51e-07	6
DN2 thymocyte	1.51e-07	6
DN3 thymocyte	1.51e-07	6
immature single positive thymocyte	1.51e-07	6
early T lineage precursor	1.51e-07	6
mature CD4 single-positive thymocyte	1.51e-07	6
resting double-positive thymocyte	1.51e-07	6
double-positive blast	1.51e-07	6
CD69-positive double-positive thymocyte	1.51e-07	6
CD69-positive, CD4-positive single-positive thymocyte	1.51e-07	6
CD4-positive, CD8-intermediate double-positive thymocyte	1.51e-07	6
CD24-positive, CD4 single-positive thymocyte	1.51e-07	6
motile cell	3.31e-07	54

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	6.67e-21	48
immune system	6.67e-21	48
hematopoietic system	9.26e-19	45
blood island	9.26e-19	45
hemopoietic organ	2.03e-18	29
immune organ	2.03e-18	29
mixed endoderm/mesoderm-derived structure	3.56e-16	35
thymus	1.16e-15	23
neck	1.16e-15	23
respiratory system epithelium	1.16e-15	23
hemolymphoid system gland	1.16e-15	23
pharyngeal epithelium	1.16e-15	23
thymic region	1.16e-15	23
pharyngeal gland	1.16e-15	23
entire pharyngeal arch endoderm	1.16e-15	23
thymus primordium	1.16e-15	23
early pharyngeal endoderm	1.16e-15	23
pharynx	1.06e-14	24
gland of gut	1.06e-14	24
upper respiratory tract	1.06e-14	24
chordate pharynx	1.06e-14	24
pharyngeal arch system	1.06e-14	24
pharyngeal region of foregut	1.06e-14	24
segment of respiratory tract	2.95e-12	27
respiratory tract	1.86e-11	41
respiratory system	5.65e-11	42
foregut	9.46e-11	80
endo-epithelium	6.93e-10	69
lateral plate mesoderm	1.12e-09	87
gut epithelium	2.75e-09	55
connective tissue	3.28e-09	46
endoderm-derived structure	6.11e-09	118
endoderm	6.11e-09	118
presumptive endoderm	6.11e-09	118
digestive system	9.29e-09	116
digestive tract	9.29e-09	116
primitive gut	9.29e-09	116
organ segment	1.03e-08	35
subdivision of digestive tract	6.27e-08	114
endocrine gland	9.39e-08	60
unilaminar epithelium	1.16e-07	66
craniocervical region	1.64e-07	36
gland	3.95e-07	65

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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