Coexpression cluster:C21
From FANTOM5_SSTAR
Full id: C21_cord_mycosis_hairy_xeroderma_adult_CD4_anaplastic
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 4.41958396189096e-06 | 0.00139879832393849 | 8 | 265 | Cytokine-cytokine receptor interaction (KEGG):04060 |
| 0.000241538166127314 | 0.0117610507045069 | 4 | 86 | Apoptosis (KEGG):04210 |
| 0.000463117162386291 | 0.0172443037523837 | 4 | 102 | Toll-like receptor signaling pathway (KEGG):04620 |
| 1.82044243043083e-05 | 0.00230468011692542 | 6 | 155 | Jak-STAT signaling pathway (KEGG):04630 |
| 0.000531913374485444 | 0.0187056203360715 | 3 | 45 | Type I diabetes mellitus (KEGG):04940 |
| 0.000375081676360726 | 0.0158284467424226 | 3 | 40 | NOD pathway (Wikipathways):WP1433 |
| 0.00150961754034394 | 0.0455041858589388 | 4 | 140 | Regulation of toll-like receptor signaling pathway (Wikipathways):WP1449 |
| 0.000230920835147294 | 0.0117610507045069 | 4 | 85 | Apoptosis (Wikipathways):WP254 |
| 0.000219923213271195 | 0.0117610507045069 | 5 | 155 | Myometrial Relaxation and Contraction Pathways (Wikipathways):WP289 |
| 0.00017459328686974 | 0.0110517550588545 | 3 | 31 | Inflammatory Response Pathway (Wikipathways):WP453 |
| 0.000463117162386291 | 0.0172443037523837 | 4 | 102 | Toll-like receptor signaling pathway (Wikipathways):WP75 |
| 0.000588150706077688 | 0.019594705102483 | 10 | 816 | TGF beta receptor up reg. targets (Netpath):NetPath_7 |
| 4.97466751400034e-05 | 0.00449852076623173 | 11 | 728 | TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9 |
| 2.17842981574292e-07 | 0.000137894607336527 | 9 | 246 | B Cell Receptor up reg. targets (Netpath):NetPath_12 |
| 7.58861832697053e-05 | 0.00600449425121543 | 7 | 291 | T Cell Receptor up reg. targets (Netpath):NetPath_11 |
| 0.000144747517990267 | 0.0101805754319821 | 8 | 433 | IL-2 up reg. targets (Netpath):NetPath_14 |
| 1.17592115203798e-05 | 0.0018608952231001 | 4 | 40 | IL-3 up reg. targets (Netpath):NetPath_15 |
| 6.9703067792969e-06 | 0.00147073473043165 | 6 | 131 | IL-5 up reg. targets (Netpath):NetPath_17 |
| 4.85589573567309e-05 | 0.00449852076623173 | 4 | 57 | IL-7 up reg. targets (Netpath):NetPath_19 |
| 0.00065459895882015 | 0.0207180570466577 | 2 | 11 | {SRF,11} (Static Module):NA |
| 0.000287540278442325 | 0.0130009283038565 | 4 | 90 | {TRAF2,90} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0032502 | developmental process | 1.49500774582632e-07 |
| GO:0048869 | cellular developmental process | 8.43475544657594e-06 |
| GO:0030154 | cell differentiation | 8.43475544657594e-06 |
| GO:0042108 | positive regulation of cytokine biosynthetic process | 1.58861084478819e-05 |
| GO:0042981 | regulation of apoptosis | 3.01525924034047e-05 |
| GO:0045727 | positive regulation of translation | 3.01525924034047e-05 |
| GO:0043067 | regulation of programmed cell death | 3.01525924034047e-05 |
| GO:0048856 | anatomical structure development | 3.01525924034047e-05 |
| GO:0006915 | apoptosis | 3.01525924034047e-05 |
| GO:0012501 | programmed cell death | 3.01525924034047e-05 |
| GO:0042035 | regulation of cytokine biosynthetic process | 3.38194740179612e-05 |
| GO:0031328 | positive regulation of cellular biosynthetic process | 3.38194740179612e-05 |
| GO:0001816 | cytokine production | 3.38194740179612e-05 |
| GO:0048518 | positive regulation of biological process | 3.38194740179612e-05 |
| GO:0008219 | cell death | 3.38194740179612e-05 |
| GO:0016265 | death | 3.38194740179612e-05 |
| GO:0048468 | cell development | 3.43848244501795e-05 |
| GO:0032501 | multicellular organismal process | 3.97653286535832e-05 |
| GO:0042089 | cytokine biosynthetic process | 4.08793527046365e-05 |
| GO:0042107 | cytokine metabolic process | 4.18323821284317e-05 |
| GO:0048522 | positive regulation of cellular process | 4.39751204868381e-05 |
| GO:0009891 | positive regulation of biosynthetic process | 4.39751204868381e-05 |
| GO:0048523 | negative regulation of cellular process | 4.99493055698714e-05 |
| GO:0048519 | negative regulation of biological process | 7.53024843162657e-05 |
| GO:0006955 | immune response | 7.74224758446347e-05 |
| GO:0002376 | immune system process | 8.7316395532495e-05 |
| GO:0051247 | positive regulation of protein metabolic process | 9.41933570233053e-05 |
| GO:0005515 | protein binding | 0.000110919809929319 |
| GO:0050789 | regulation of biological process | 0.000125913431002938 |
| GO:0043065 | positive regulation of apoptosis | 0.000140457546105976 |
| GO:0043068 | positive regulation of programmed cell death | 0.000143032072665523 |
| GO:0007275 | multicellular organismal development | 0.000200032693877108 |
| GO:0048513 | organ development | 0.000200032693877108 |
| GO:0006417 | regulation of translation | 0.000225269985772436 |
| GO:0007154 | cell communication | 0.000332174770939847 |
| GO:0031326 | regulation of cellular biosynthetic process | 0.000332174770939847 |
| GO:0009889 | regulation of biosynthetic process | 0.000526917710568071 |
| GO:0050794 | regulation of cellular process | 0.000603718383726097 |
| GO:0045624 | positive regulation of T-helper cell differentiation | 0.000893072188027579 |
| GO:0031325 | positive regulation of cellular metabolic process | 0.00103079348207043 |
| GO:0044464 | cell part | 0.0011409662857749 |
| GO:0065007 | biological regulation | 0.00114619649860008 |
| GO:0048731 | system development | 0.00128764694845305 |
| GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | 0.00131708534439334 |
| GO:0009893 | positive regulation of metabolic process | 0.001410548363818 |
| GO:0014706 | striated muscle development | 0.00158449807157633 |
| GO:0007165 | signal transduction | 0.00161768696755108 |
| GO:0004907 | interleukin receptor activity | 0.00173447883537934 |
| GO:0045622 | regulation of T-helper cell differentiation | 0.00247527565454036 |
| GO:0019965 | interleukin binding | 0.00271848924205856 |
| GO:0048741 | skeletal muscle fiber development | 0.00298972826275766 |
| GO:0048747 | muscle fiber development | 0.00298972826275766 |
| GO:0042534 | regulation of tumor necrosis factor biosynthetic process | 0.00298972826275766 |
| GO:0042533 | tumor necrosis factor biosynthetic process | 0.00298972826275766 |
| GO:0044424 | intracellular part | 0.00316563976687119 |
| GO:0001775 | cell activation | 0.00340958086088433 |
| GO:0006917 | induction of apoptosis | 0.00353252198552042 |
| GO:0042692 | muscle cell differentiation | 0.00353252198552042 |
| GO:0012502 | induction of programmed cell death | 0.00353252198552042 |
| GO:0002286 | T cell activation during immune response | 0.00385957739445904 |
| GO:0002292 | T cell differentiation during immune response | 0.00385957739445904 |
| GO:0002293 | alpha-beta T cell differentiation during immune response | 0.00385957739445904 |
| GO:0002263 | cell activation during immune response | 0.00385957739445904 |
| GO:0002294 | CD4-positive, alpha-beta T cell differentiation during immune response | 0.00385957739445904 |
| GO:0042093 | T-helper cell differentiation | 0.00385957739445904 |
| GO:0002366 | leukocyte activation during immune response | 0.00385957739445904 |
| GO:0002285 | lymphocyte activation during immune response | 0.00385957739445904 |
| GO:0005886 | plasma membrane | 0.00429899821630036 |
| GO:0043367 | CD4-positive, alpha beta T cell differentiation | 0.00444399837717761 |
| GO:0051881 | regulation of mitochondrial membrane potential | 0.00444399837717761 |
| GO:0045086 | positive regulation of interleukin-2 biosynthetic process | 0.00444399837717761 |
| GO:0043565 | sequence-specific DNA binding | 0.00529263843539813 |
| GO:0031324 | negative regulation of cellular metabolic process | 0.00575268141348506 |
| GO:0001836 | release of cytochrome c from mitochondria | 0.00594618373458173 |
| GO:0032640 | tumor necrosis factor production | 0.00594618373458173 |
| GO:0045595 | regulation of cell differentiation | 0.00632829546426433 |
| GO:0031323 | regulation of cellular metabolic process | 0.00660163185068976 |
| GO:0030552 | cAMP binding | 0.00660163185068976 |
| GO:0044425 | membrane part | 0.00660163185068976 |
| GO:0045076 | regulation of interleukin-2 biosynthetic process | 0.00747894415439232 |
| GO:0007242 | intracellular signaling cascade | 0.00754971572414546 |
| GO:0008283 | cell proliferation | 0.00754971572414546 |
| GO:0007519 | skeletal muscle development | 0.00754971572414546 |
| GO:0016020 | membrane | 0.00767182557346279 |
| GO:0046632 | alpha-beta T cell differentiation | 0.00767182557346279 |
| GO:0042246 | tissue regeneration | 0.00767182557346279 |
| GO:0042094 | interleukin-2 biosynthetic process | 0.00767182557346279 |
| GO:0015026 | coreceptor activity | 0.00767182557346279 |
| GO:0004896 | hematopoietin/interferon-class (D200-domain) cytokine receptor activity | 0.00767182557346279 |
| GO:0051246 | regulation of protein metabolic process | 0.00795037287864846 |
| GO:0001558 | regulation of cell growth | 0.00821053994651576 |
| GO:0009892 | negative regulation of metabolic process | 0.00920259387819634 |
| GO:0016481 | negative regulation of transcription | 0.009228042657909 |
| GO:0031099 | regeneration | 0.009228042657909 |
| GO:0006916 | anti-apoptosis | 0.00932225822687075 |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.00932225822687075 |
| GO:0002250 | adaptive immune response | 0.00932225822687075 |
| GO:0007517 | muscle development | 0.00952084001990232 |
| GO:0046631 | alpha-beta T cell activation | 0.00967856012843892 |
| GO:0008637 | apoptotic mitochondrial changes | 0.00967856012843892 |
| GO:0031967 | organelle envelope | 0.0102313453710889 |
| GO:0031975 | envelope | 0.0103195321465514 |
| GO:0005789 | endoplasmic reticulum membrane | 0.0104863356898573 |
| GO:0010468 | regulation of gene expression | 0.0104863356898573 |
| GO:0045321 | leukocyte activation | 0.0105090527986157 |
| GO:0016563 | transcription activator activity | 0.0105623175693176 |
| GO:0032623 | interleukin-2 production | 0.0109314920119259 |
| GO:0016208 | AMP binding | 0.0109314920119259 |
| GO:0005622 | intracellular | 0.0109314920119259 |
| GO:0042175 | nuclear envelope-endoplasmic reticulum network | 0.0109314920119259 |
| GO:0012505 | endomembrane system | 0.0109547916133761 |
| GO:0042127 | regulation of cell proliferation | 0.0109715880166056 |
| GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0113983960528402 |
| GO:0019222 | regulation of metabolic process | 0.0114213029962913 |
| GO:0009653 | anatomical structure morphogenesis | 0.0119891606259328 |
| GO:0008632 | apoptotic program | 0.0121863702310502 |
| GO:0019838 | growth factor binding | 0.0121863702310502 |
| GO:0003700 | transcription factor activity | 0.0125549750258581 |
| GO:0043229 | intracellular organelle | 0.0130593415690987 |
| GO:0031090 | organelle membrane | 0.0130593415690987 |
| GO:0043226 | organelle | 0.0130593415690987 |
| GO:0040008 | regulation of growth | 0.0134345163758442 |
| GO:0016049 | cell growth | 0.0134345163758442 |
| GO:0030551 | cyclic nucleotide binding | 0.0135559172849289 |
| GO:0045892 | negative regulation of transcription, DNA-dependent | 0.0137040041133225 |
| GO:0008361 | regulation of cell size | 0.0143388068469794 |
| GO:0019955 | cytokine binding | 0.0148365007816447 |
| GO:0045445 | myoblast differentiation | 0.0148365007816447 |
| GO:0044432 | endoplasmic reticulum part | 0.0148365007816447 |
| GO:0005783 | endoplasmic reticulum | 0.0148365007816447 |
| GO:0045554 | regulation of TRAIL biosynthetic process | 0.0148365007816447 |
| GO:0051149 | positive regulation of muscle cell differentiation | 0.0148365007816447 |
| GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity | 0.0148365007816447 |
| GO:0005140 | interleukin-9 receptor binding | 0.0148365007816447 |
| GO:0042225 | interleukin-5 biosynthetic process | 0.0148365007816447 |
| GO:0032634 | interleukin-5 production | 0.0148365007816447 |
| GO:0030526 | granulocyte macrophage colony-stimulating factor receptor complex | 0.0148365007816447 |
| GO:0001532 | interleukin-21 receptor activity | 0.0148365007816447 |
| GO:0045405 | regulation of interleukin-5 biosynthetic process | 0.0148365007816447 |
| GO:0043017 | positive regulation of lymphotoxin A biosynthetic process | 0.0148365007816447 |
| GO:0045556 | positive regulation of TRAIL biosynthetic process | 0.0148365007816447 |
| GO:0045407 | positive regulation of interleukin-5 biosynthetic process | 0.0148365007816447 |
| GO:0043416 | regulation of skeletal muscle regeneration | 0.0148365007816447 |
| GO:0019977 | interleukin-21 binding | 0.0148365007816447 |
| GO:0015853 | adenine transport | 0.0148365007816447 |
| GO:0045553 | TRAIL biosynthetic process | 0.0148365007816447 |
| GO:0051155 | positive regulation of striated muscle cell differentiation | 0.0148365007816447 |
| GO:0043415 | positive regulation of skeletal muscle regeneration | 0.0148365007816447 |
| GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity | 0.0148365007816447 |
| GO:0051153 | regulation of striated muscle cell differentiation | 0.0148365007816447 |
| GO:0008434 | vitamin D3 receptor activity | 0.0148365007816447 |
| GO:0043016 | regulation of lymphotoxin A biosynthetic process | 0.0148365007816447 |
| GO:0032639 | TRAIL production | 0.0148365007816447 |
| GO:0042802 | identical protein binding | 0.0148365007816447 |
| GO:0046983 | protein dimerization activity | 0.0150917281923931 |
| GO:0015758 | glucose transport | 0.0154932826258501 |
| GO:0016021 | integral to membrane | 0.0156233320604472 |
| GO:0043066 | negative regulation of apoptosis | 0.0162220196881869 |
| GO:0042391 | regulation of membrane potential | 0.0162220196881869 |
| GO:0008643 | carbohydrate transport | 0.0165875433420822 |
| GO:0031224 | intrinsic to membrane | 0.0165875433420822 |
| GO:0043069 | negative regulation of programmed cell death | 0.0165875433420822 |
| GO:0008645 | hexose transport | 0.0167477849539627 |
| GO:0015749 | monosaccharide transport | 0.0167477849539627 |
| GO:0045087 | innate immune response | 0.0174662855189097 |
| GO:0065008 | regulation of biological quality | 0.0175432616133144 |
| GO:0050793 | regulation of developmental process | 0.0176409802980086 |
| GO:0055082 | cellular chemical homeostasis | 0.0176969134404418 |
| GO:0006873 | cellular ion homeostasis | 0.0176969134404418 |
| GO:0048589 | developmental growth | 0.0215129134125044 |
| GO:0031966 | mitochondrial membrane | 0.0217058515413011 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 0.0223387583004768 |
| GO:0043231 | intracellular membrane-bound organelle | 0.0223387583004768 |
| GO:0005164 | tumor necrosis factor receptor binding | 0.0223387583004768 |
| GO:0003704 | specific RNA polymerase II transcription factor activity | 0.0223387583004768 |
| GO:0015833 | peptide transport | 0.0223387583004768 |
| GO:0043227 | membrane-bound organelle | 0.0223387583004768 |
| GO:0009611 | response to wounding | 0.0223387583004768 |
| GO:0030217 | T cell differentiation | 0.0223387583004768 |
| GO:0032813 | tumor necrosis factor receptor superfamily binding | 0.0223387583004768 |
| GO:0051952 | regulation of amine transport | 0.0223387583004768 |
| GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity | 0.0223387583004768 |
| GO:0008160 | protein tyrosine phosphatase activator activity | 0.0223387583004768 |
| GO:0051953 | negative regulation of amine transport | 0.0223387583004768 |
| GO:0051956 | negative regulation of amino acid transport | 0.0223387583004768 |
| GO:0042637 | catagen | 0.0223387583004768 |
| GO:0008269 | JAK pathway signal transduction adaptor activity | 0.0223387583004768 |
| GO:0006863 | purine transport | 0.0223387583004768 |
| GO:0004912 | interleukin-3 receptor activity | 0.0223387583004768 |
| GO:0051955 | regulation of amino acid transport | 0.0223387583004768 |
| GO:0005459 | UDP-galactose transmembrane transporter activity | 0.0223387583004768 |
| GO:0002036 | regulation of L-glutamate transport | 0.0223387583004768 |
| GO:0051902 | negative regulation of mitochondrial depolarization | 0.0223387583004768 |
| GO:0045747 | positive regulation of Notch signaling pathway | 0.0223387583004768 |
| GO:0004949 | cannabinoid receptor activity | 0.0223387583004768 |
| GO:0045630 | positive regulation of T-helper 2 cell differentiation | 0.0223387583004768 |
| GO:0016312 | inositol bisphosphate phosphatase activity | 0.0223387583004768 |
| GO:0045627 | positive regulation of T-helper 1 cell differentiation | 0.0223387583004768 |
| GO:0004240 | mitochondrial processing peptidase activity | 0.0223387583004768 |
| GO:0019978 | interleukin-3 binding | 0.0223387583004768 |
| GO:0005148 | prolactin receptor binding | 0.0223387583004768 |
| GO:0005638 | lamin filament | 0.0223387583004768 |
| GO:0002037 | negative regulation of L-glutamate transport | 0.0223387583004768 |
| GO:0050801 | ion homeostasis | 0.0223387583004768 |
| GO:0005740 | mitochondrial envelope | 0.0229951857836712 |
| GO:0045941 | positive regulation of transcription | 0.0257881464991527 |
| GO:0009605 | response to external stimulus | 0.0257881464991527 |
| GO:0001932 | regulation of protein amino acid phosphorylation | 0.0257881464991527 |
| GO:0033238 | regulation of amine metabolic process | 0.0266140592040035 |
| GO:0006521 | regulation of amino acid metabolic process | 0.0266140592040035 |
| GO:0007267 | cell-cell signaling | 0.0266140592040035 |
| GO:0006366 | transcription from RNA polymerase II promoter | 0.0266140592040035 |
| GO:0045597 | positive regulation of cell differentiation | 0.0274056030594895 |
| GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0280532702359227 |
| GO:0009967 | positive regulation of signal transduction | 0.0287154921574366 |
| GO:0005887 | integral to plasma membrane | 0.0287154921574366 |
| GO:0046649 | lymphocyte activation | 0.0287154921574366 |
| GO:0019976 | interleukin-2 binding | 0.0287154921574366 |
| GO:0008339 | MP kinase activity | 0.0287154921574366 |
| GO:0005594 | collagen type IX | 0.0287154921574366 |
| GO:0005047 | signal recognition particle binding | 0.0287154921574366 |
| GO:0045625 | regulation of T-helper 1 cell differentiation | 0.0287154921574366 |
| GO:0042109 | lymphotoxin A biosynthetic process | 0.0287154921574366 |
| GO:0042097 | interleukin-4 biosynthetic process | 0.0287154921574366 |
| GO:0045663 | positive regulation of myoblast differentiation | 0.0287154921574366 |
| GO:0045425 | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | 0.0287154921574366 |
| GO:0045404 | positive regulation of interleukin-4 biosynthetic process | 0.0287154921574366 |
| GO:0004911 | interleukin-2 receptor activity | 0.0287154921574366 |
| GO:0008268 | receptor signaling protein tyrosine kinase signaling protein activity | 0.0287154921574366 |
| GO:0045402 | regulation of interleukin-4 biosynthetic process | 0.0287154921574366 |
| GO:0004914 | interleukin-5 receptor activity | 0.0287154921574366 |
| GO:0004875 | complement receptor activity | 0.0287154921574366 |
| GO:0019980 | interleukin-5 binding | 0.0287154921574366 |
| GO:0042825 | TAP complex | 0.0287154921574366 |
| GO:0032641 | lymphotoxin A production | 0.0287154921574366 |
| GO:0016081 | synaptic vesicle docking during exocytosis | 0.0287154921574366 |
| GO:0005782 | peroxisomal matrix | 0.0287154921574366 |
| GO:0048878 | chemical homeostasis | 0.0293547480395403 |
| GO:0031226 | intrinsic to plasma membrane | 0.0296867931153594 |
| GO:0042803 | protein homodimerization activity | 0.0296867931153594 |
| GO:0005792 | microsome | 0.031469153460369 |
| GO:0005125 | cytokine activity | 0.031469153460369 |
| GO:0005624 | membrane fraction | 0.031469153460369 |
| GO:0000267 | cell fraction | 0.0323568625903247 |
| GO:0005737 | cytoplasm | 0.0327997561796075 |
| GO:0042598 | vesicular fraction | 0.0340694946740813 |
| GO:0005126 | hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 0.0340694946740813 |
| GO:0051046 | regulation of secretion | 0.0340694946740813 |
| GO:0008593 | regulation of Notch signaling pathway | 0.0340694946740813 |
| GO:0046977 | TAP binding | 0.0340694946740813 |
| GO:0045423 | regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | 0.0340694946740813 |
| GO:0006002 | fructose 6-phosphate metabolic process | 0.0340694946740813 |
| GO:0032633 | interleukin-4 production | 0.0340694946740813 |
| GO:0043403 | skeletal muscle regeneration | 0.0340694946740813 |
| GO:0042824 | MHC class I peptide loading complex | 0.0340694946740813 |
| GO:0045063 | T-helper 1 cell differentiation | 0.0340694946740813 |
| GO:0045628 | regulation of T-helper 2 cell differentiation | 0.0340694946740813 |
| GO:0046325 | negative regulation of glucose import | 0.0340694946740813 |
| GO:0005652 | nuclear lamina | 0.0340694946740813 |
| GO:0046979 | TAP2 binding | 0.0340694946740813 |
| GO:0015851 | nucleobase transport | 0.0340694946740813 |
| GO:0051900 | regulation of mitochondrial depolarization | 0.0340694946740813 |
| GO:0046978 | TAP1 binding | 0.0340694946740813 |
| GO:0051147 | regulation of muscle cell differentiation | 0.0340694946740813 |
| GO:0031403 | lithium ion binding | 0.0340694946740813 |
| GO:0005131 | growth hormone receptor binding | 0.0340694946740813 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.0341293557606267 |
| GO:0044446 | intracellular organelle part | 0.0343495500712108 |
| GO:0044422 | organelle part | 0.0353336985007209 |
| GO:0002520 | immune system development | 0.038683223776192 |
| GO:0042325 | regulation of phosphorylation | 0.0389018632124227 |
| GO:0030098 | lymphocyte differentiation | 0.0389018632124227 |
| GO:0005615 | extracellular space | 0.0390374584067696 |
| GO:0051882 | mitochondrial depolarization | 0.0399774524393771 |
| GO:0045410 | positive regulation of interleukin-6 biosynthetic process | 0.0399774524393771 |
| GO:0008035 | high-density lipoprotein binding | 0.0399774524393771 |
| GO:0046790 | virion binding | 0.0399774524393771 |
| GO:0032604 | granulocyte macrophage colony-stimulating factor production | 0.0399774524393771 |
| GO:0042253 | granulocyte macrophage colony-stimulating factor biosynthetic process | 0.0399774524393771 |
| GO:0045064 | T-helper 2 cell differentiation | 0.0399774524393771 |
| GO:0005954 | calcium- and calmodulin-dependent protein kinase complex | 0.0399774524393771 |
| GO:0048535 | lymph node development | 0.0399774524393771 |
| GO:0046902 | regulation of mitochondrial membrane permeability | 0.0399774524393771 |
| GO:0051094 | positive regulation of developmental process | 0.0418201482636928 |
| GO:0051174 | regulation of phosphorus metabolic process | 0.0426960672384591 |
| GO:0019220 | regulation of phosphate metabolic process | 0.0426960672384591 |
| GO:0005635 | nuclear envelope | 0.0431566496498217 |
| GO:0002449 | lymphocyte mediated immunity | 0.0450464672686323 |
| GO:0017111 | nucleoside-triphosphatase activity | 0.0450464672686323 |
| GO:0015165 | pyrimidine nucleotide sugar transmembrane transporter activity | 0.0450464672686323 |
| GO:0050806 | positive regulation of synaptic transmission | 0.0450464672686323 |
| GO:0008634 | negative regulation of survival gene product activity | 0.0450464672686323 |
| GO:0005786 | signal recognition particle, endoplasmic reticulum targeting | 0.0450464672686323 |
| GO:0045661 | regulation of myoblast differentiation | 0.0450464672686323 |
| GO:0015198 | oligopeptide transporter activity | 0.0450464672686323 |
| GO:0005593 | FACIT collagen | 0.0450464672686323 |
| GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | 0.0450464672686323 |
| GO:0016909 | SAP kinase activity | 0.0450464672686323 |
| GO:0002347 | response to tumor cell | 0.0450464672686323 |
| GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | 0.0450464672686323 |
| GO:0001848 | complement binding | 0.0450464672686323 |
| GO:0004872 | receptor activity | 0.0458888596894514 |
| GO:0006959 | humoral immune response | 0.0471958199067331 |
| GO:0019725 | cellular homeostasis | 0.0476177913335884 |
| GO:0017016 | Ras GTPase binding | 0.0492732528790226 |
| GO:0044459 | plasma membrane part | 0.0499005036276877 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| leukocyte | 3.41e-36 | 140 |
| hematopoietic stem cell | 3.11e-28 | 172 |
| angioblastic mesenchymal cell | 3.11e-28 | 172 |
| hematopoietic lineage restricted progenitor cell | 5.26e-27 | 124 |
| hematopoietic oligopotent progenitor cell | 5.88e-27 | 165 |
| hematopoietic multipotent progenitor cell | 5.88e-27 | 165 |
| nongranular leukocyte | 8.69e-27 | 119 |
| hematopoietic cell | 2.99e-26 | 182 |
| lymphocyte | 1.59e-18 | 53 |
| common lymphoid progenitor | 1.59e-18 | 53 |
| lymphoid lineage restricted progenitor cell | 4.63e-18 | 52 |
| myeloid leukocyte | 2.21e-13 | 76 |
| CD14-positive, CD16-negative classical monocyte | 1.21e-11 | 42 |
| lymphocyte of B lineage | 2.33e-11 | 24 |
| pro-B cell | 2.33e-11 | 24 |
| classical monocyte | 4.09e-11 | 45 |
| granulocyte monocyte progenitor cell | 7.97e-11 | 71 |
| myeloid cell | 1.36e-10 | 112 |
| common myeloid progenitor | 1.36e-10 | 112 |
| macrophage dendritic cell progenitor | 1.27e-09 | 65 |
| myeloid lineage restricted progenitor cell | 2.03e-09 | 70 |
| monopoietic cell | 9.54e-09 | 63 |
| monocyte | 9.54e-09 | 63 |
| monoblast | 9.54e-09 | 63 |
| promonocyte | 9.54e-09 | 63 |
| T cell | 9.39e-07 | 25 |
| pro-T cell | 9.39e-07 | 25 |
| Ontology term | p-value | n |
|---|---|---|
| hematopoietic system | 1.57e-15 | 102 |
| blood island | 1.57e-15 | 102 |
| hemolymphoid system | 5.31e-14 | 112 |
| adult organism | 1.11e-13 | 115 |
| neural tube | 3.06e-09 | 57 |
| neural rod | 3.06e-09 | 57 |
| future spinal cord | 3.06e-09 | 57 |
| neural keel | 3.06e-09 | 57 |
| bone element | 8.69e-09 | 86 |
| bone marrow | 9.00e-09 | 80 |
| regional part of forebrain | 3.83e-08 | 41 |
| forebrain | 3.83e-08 | 41 |
| future forebrain | 3.83e-08 | 41 |
| central nervous system | 4.59e-08 | 82 |
| anterior neural tube | 1.01e-07 | 42 |
| gray matter | 2.29e-07 | 34 |
| brain grey matter | 2.29e-07 | 34 |
| immune system | 4.32e-07 | 115 |
| telencephalon | 5.42e-07 | 34 |
| cerebral hemisphere | 7.97e-07 | 32 |
| regional part of telencephalon | 8.59e-07 | 33 |
| Ontology term | p-value | n |
|---|---|---|
| lymphoma | 3.01e-07 | 10 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.
