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Coexpression cluster:C2147

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Full id: C2147_argyrophil_lung_trachea_gastrointestinal_throat_caudate_aorta



Phase1 CAGE Peaks

Hg19::chr11:6260298..6260333,+p1@CNGA4
Hg19::chr12:52487297..52487308,+p1@ENST00000546981
Hg19::chr12:52487330..52487335,+p2@ENST00000546981
Hg19::chr21:47738093..47738106,-p6@C21orf58


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism1.28e-20114
neural nucleus1.72e-179
nucleus of brain1.72e-179
brainstem3.41e-176
corpus striatum8.21e-154
striatum8.21e-154
ventral part of telencephalon8.21e-154
future corpus striatum8.21e-154
open tracheal system trachea1.65e-142
throat2.02e-142
caudate nucleus8.06e-142
future caudate nucleus8.06e-142
locus ceruleus8.60e-142
brainstem nucleus8.60e-142
hindbrain nucleus8.60e-142
regional part of nervous system5.70e-1053
regional part of brain5.70e-1053
caudate-putamen1.64e-093
dorsal striatum1.64e-093
pons1.71e-093
medulla oblongata2.12e-093
myelencephalon2.12e-093
future myelencephalon2.12e-093
neural tube2.33e-0956
neural rod2.33e-0956
future spinal cord2.33e-0956
neural keel2.33e-0956
telencephalic nucleus1.10e-087
segmental subdivision of hindbrain1.11e-0812
hindbrain1.11e-0812
presumptive hindbrain1.11e-0812
lower lobe of right lung3.32e-081
right lung lobe3.32e-081
lower lobe of lung3.32e-081
lobe of lung3.32e-081
right lung3.32e-081
maxillary sinus4.35e-081
paranasal sinus4.35e-081
epididymis4.99e-081
segmental subdivision of nervous system5.08e-0813
uterus or analog1.18e-071
corpus callosum1.54e-071
central nervous system cell part cluster1.54e-071
axon tract1.54e-071
intercerebral commissure1.54e-071
dorsal telencephalic commissure1.54e-071
brain white matter1.54e-071
brain commissure1.54e-071
white matter1.54e-071
nervous system commissure1.54e-071
cerebral hemisphere white matter1.54e-071
nucleus accumbens1.87e-071
ventral striatum1.87e-071
brain2.57e-0768
future brain2.57e-0768
posterior neural tube5.78e-0715
chordal neural plate5.78e-0715
basal ganglion7.41e-079
nuclear complex of neuraxis7.41e-079
aggregate regional part of brain7.41e-079
collection of basal ganglia7.41e-079
cerebral subcortex7.41e-079
Disease
Ontology termp-valuen
paranasal sinus cancer4.35e-081
maxillary sinus cancer4.35e-081


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.12.98182
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.11.9583
MA0101.10.539569
MA0103.11.29536
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.13.57466
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.257871
MA0138.20.928035
MA0002.21.75253
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.00910927
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.