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Coexpression cluster:C4117: Difference between revisions

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|full_id=C4117_Urothelial_small_Corneal_tubular_Smooth_cervical_pharyngeal
|full_id=C4117_Urothelial_small_Corneal_tubular_Smooth_cervical_pharyngeal
|id=C4117
|id=C4117
|ontology_enrichment_celltype=CL:0000066!2.55e-18!254;CL:0000220!1.04e-12!246;CL:0002321!3.04e-12!248;CL:0002078!1.02e-11!44;CL:0000115!2.04e-11!35;CL:0002139!3.08e-11!24;CL:0000071!6.43e-10!18;CL:0002546!6.43e-10!18;CL:0000222!9.91e-10!119;CL:0000076!1.28e-09!62;CL:0002076!4.98e-09!43;CL:1000497!2.29e-08!18;CL:0002518!2.29e-08!18;CL:1000449!7.66e-08!16;CL:0000213!2.82e-07!57;CL:0000215!2.82e-07!57;CL:0000223!5.92e-07!59
|ontology_enrichment_celltype=CL:0000066!1.49e-17!253;CL:0002078!1.39e-13!45;CL:0000115!5.06e-13!36;CL:0002321!1.06e-11!250;CL:0002139!1.14e-11!24;CL:0000222!2.48e-10!121;CL:0000071!3.99e-10!18;CL:0002546!3.99e-10!18;CL:0000076!1.28e-09!63;CL:0002076!1.77e-09!42;CL:1000497!3.12e-09!17;CL:0002518!3.12e-09!17;CL:1000449!1.10e-08!15;CL:0000213!1.17e-08!58;CL:0000215!1.17e-08!58;CL:0002681!2.96e-07!12;CL:0002584!2.96e-07!12;CL:0002368!3.23e-07!13;CL:0000223!3.40e-07!58
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000483!7.09e-25!309;UBERON:0004111!9.43e-25!241;UBERON:0000119!1.79e-24!312;UBERON:0000467!2.27e-22!625;UBERON:0000468!2.81e-22!659;UBERON:0000480!4.80e-22!626;UBERON:0000477!1.11e-21!286;UBERON:0000481!1.02e-20!347;UBERON:0000475!1.57e-19!365;UBERON:0003914!8.92e-19!118;UBERON:0000025!2.57e-17!194;UBERON:0002100!2.90e-15!216;UBERON:0004119!9.07e-15!169;UBERON:0000925!9.07e-15!169;UBERON:0006595!9.07e-15!169;UBERON:0000464!4.05e-14!104;UBERON:0003104!4.33e-14!238;UBERON:0009142!4.33e-14!238;UBERON:0000064!4.55e-14!219;UBERON:0004872!6.31e-14!84;UBERON:0000055!7.43e-14!69;UBERON:0002050!1.16e-13!605;UBERON:0005423!1.16e-13!605;UBERON:0000922!1.74e-13!612;UBERON:0000923!2.49e-13!604;UBERON:0005291!2.49e-13!604;UBERON:0006598!2.49e-13!604;UBERON:0002532!2.49e-13!604;UBERON:0002049!5.02e-13!79;UBERON:0007798!5.02e-13!79;UBERON:0001981!1.07e-12!60;UBERON:0007500!1.07e-12!60;UBERON:0004537!1.07e-12!60;UBERON:0006965!1.07e-12!60;UBERON:0003103!1.51e-12!69;UBERON:0000466!5.04e-12!126;UBERON:0001007!7.71e-12!155;UBERON:0001555!7.71e-12!155;UBERON:0007026!7.71e-12!155;UBERON:0004921!1.40e-11!129;UBERON:0004185!1.40e-11!129;UBERON:0000487!1.42e-11!22;UBERON:0000490!4.36e-11!138;UBERON:0001008!6.37e-11!45;UBERON:0005177!6.53e-11!107;UBERON:0000062!7.28e-11!511;UBERON:0006554!1.08e-10!44;UBERON:0006914!1.61e-10!25;UBERON:0003064!3.19e-10!37;UBERON:0001986!6.43e-10!18;UBERON:0004638!6.43e-10!18;UBERON:0004852!6.43e-10!18;UBERON:0009569!1.19e-09!113;UBERON:0005157!5.61e-09!51;UBERON:0001009!9.14e-09!113;UBERON:0000077!1.01e-08!130;UBERON:0000058!1.19e-08!26;UBERON:0004535!2.80e-08!110;UBERON:0002553!2.86e-08!70;UBERON:0005256!4.06e-08!143;UBERON:0003886!4.83e-08!63;UBERON:0001048!6.21e-08!168;UBERON:0004211!7.66e-08!16;UBERON:0001285!7.66e-08!16;UBERON:0007684!7.66e-08!16;UBERON:0003220!7.66e-08!16;UBERON:0004208!7.66e-08!16;UBERON:0006555!9.09e-08!17;UBERON:0005103!9.09e-08!17;UBERON:0000083!9.09e-08!17;UBERON:0009201!9.09e-08!17;UBERON:0004819!9.09e-08!17;UBERON:0006553!9.09e-08!17;UBERON:0003074!9.09e-08!17;UBERON:0003060!9.09e-08!17;UBERON:0004876!1.11e-07!20;UBERON:0000915!1.12e-07!52;UBERON:0001637!1.38e-07!42;UBERON:0003509!1.38e-07!42;UBERON:0004572!1.38e-07!42;UBERON:0000080!1.44e-07!18;UBERON:0002120!1.44e-07!18;UBERON:0004875!1.44e-07!18;UBERON:0005721!1.44e-07!18;UBERON:0005754!1.44e-07!18;UBERON:0007297!1.44e-07!18;UBERON:0005153!2.22e-07!37;UBERON:0005181!3.41e-07!35;UBERON:0005178!4.95e-07!34;UBERON:0002224!4.95e-07!34;UBERON:0000063!5.40e-07!97;UBERON:0005911!5.67e-07!82;UBERON:0000926!6.14e-07!448;UBERON:0004120!6.14e-07!448;UBERON:0006603!6.14e-07!448;UBERON:0007196!9.06e-07!14;UBERON:0001558!9.06e-07!14
|ontology_enrichment_uberon=UBERON:0000477!2.81e-24!373;UBERON:0000467!7.41e-23!624;UBERON:0000480!1.46e-22!625;UBERON:0004111!4.97e-22!240;UBERON:0000483!9.14e-22!306;UBERON:0000468!3.05e-21!656;UBERON:0000119!3.76e-21!309;UBERON:0003914!2.48e-17!117;UBERON:0000475!1.23e-16!264;UBERON:0000481!5.85e-16!342;UBERON:0000025!1.51e-15!192;UBERON:0002100!2.46e-15!199;UBERON:0000055!1.27e-13!68;UBERON:0000064!4.20e-13!218;UBERON:0004872!4.48e-13!83;UBERON:0002049!9.14e-13!78;UBERON:0007798!9.14e-13!78;UBERON:0000464!2.10e-12!95;UBERON:0003103!2.15e-12!68;UBERON:0007500!3.27e-12!59;UBERON:0001981!3.27e-12!59;UBERON:0004537!3.27e-12!59;UBERON:0006965!3.27e-12!59;UBERON:0000487!7.66e-12!22;UBERON:0000922!1.27e-11!592;UBERON:0004119!1.31e-11!160;UBERON:0000925!1.31e-11!160;UBERON:0006595!1.31e-11!160;UBERON:0000062!1.36e-11!503;UBERON:0005177!3.46e-11!101;UBERON:0001008!5.29e-11!48;UBERON:0006914!7.24e-11!25;UBERON:0006554!7.86e-11!47;UBERON:0005423!8.48e-11!581;UBERON:0004638!3.99e-10!18;UBERON:0001986!3.99e-10!18;UBERON:0004852!3.99e-10!18;UBERON:0009569!4.88e-10!112;UBERON:0000466!6.28e-10!117;UBERON:0000490!2.43e-09!148;UBERON:0004921!6.71e-09!118;UBERON:0001007!7.47e-09!145;UBERON:0001555!7.47e-09!145;UBERON:0007026!7.47e-09!145;UBERON:0002050!9.40e-09!564;UBERON:0004211!1.10e-08!15;UBERON:0009773!1.10e-08!15;UBERON:0001231!1.10e-08!15;UBERON:0001285!1.10e-08!15;UBERON:0007684!1.10e-08!15;UBERON:0004208!1.10e-08!15;UBERON:0001009!1.14e-08!112;UBERON:0005157!1.49e-08!47;UBERON:0006555!1.63e-08!16;UBERON:0004819!1.63e-08!16;UBERON:0000923!3.26e-08!560;UBERON:0010316!3.26e-08!560;UBERON:0005291!3.26e-08!560;UBERON:0006598!3.26e-08!560;UBERON:0010317!3.26e-08!560;UBERON:0002532!3.26e-08!560;UBERON:0004535!3.39e-08!109;UBERON:0005181!3.39e-08!35;UBERON:0000915!3.68e-08!52;UBERON:0005178!4.53e-08!34;UBERON:0002224!4.53e-08!34;UBERON:0003064!6.59e-08!28;UBERON:0003104!7.07e-08!160;UBERON:0009142!7.07e-08!160;UBERON:0000058!1.24e-07!19;UBERON:0005153!2.06e-07!37;UBERON:0001225!2.96e-07!12;UBERON:0008987!2.96e-07!12;UBERON:0000353!3.16e-07!15;UBERON:0007196!3.76e-07!15;UBERON:0001558!3.76e-07!15;UBERON:0001637!8.09e-07!42;UBERON:0003509!8.09e-07!42;UBERON:0004572!8.09e-07!42;UBERON:0005911!8.27e-07!82
|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.0280021133119857!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0326060606132738!ESR1#2099;3:30.7686032961545:3.43136389821584e-05:0.00067795727235294!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0295070382698489
|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.0280021133119857!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0326060606132738!ESR1#2099;3:30.7686032961545:3.43136389821584e-05:0.00067795727235294!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0295070382698489
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0558058,0.28262,0.517717,0.137332,0.0145999,0.0656973,0.211746,0.220538,0.0801488,0.0757897,0.161801,0.193215,0.0549034,0.0779715,0.0561838,0.0417636,0.0345419,0.0388736,0.254674,0.170307,0.201033,0.0488949,0.00102636,0.370421,0.0330727,0.00956472,0.219556,0.0394698,0.0596469,0.419264,0.122476,0.108872,0.11002,0.26144,0.0286025,0.190156,0.144567,0.038848,0.0874516,0.0550279,0.144067,0.253693,0.217069,0.190048,0.131088,0.090504,0.237101,0.286988,0.0761239,0.172491,0.0818785,0.182701,0.335058,0.147698,0.141463,0.167267,0.140622,0.0889592,0.309588,0.28711,0.0473033,0.094881,0.118532,0.132886,0.0774373,0.109194,0.128564,0.131452,0.687347,0.448776,0.051838,0.0993999,0.0500365,0.061829,0.0755121,0.0936516,0.144075,0.0340203,0.0741807,0.277091,0.739716,0.655293,0.21727,0.289306,0.119215,0.192475,0.177967,0.547859,0.057571,0.047591,0.392974,0.0608699,0.175319,0.300597,0.0713214,0.223874,0.291114,0.0355833,0.125606,0.175094,0.43617,0.297678,0.206454,0.218192,0.108277,0.0673484,0.108748,0.0494066,0.0958493,0.205732,0.0755808,0.045654,0.110216,0.070276,0.226171,0.153469,0.0376916,0.13262,0.0450031,0.0539144,0.114242,0.0929549,0.172425,0.104948,0.221645,0.057168,0.234298,0.0759837,0.0457643,0.152372,0.194941,0.218271,0.101607,0.327067,0.172982,0.340936,0.151597,0.0626744,0.191335,0.148574,0.504592,0.155821,0.0718905,0.0919008,0.0602373,0.144304,0.15063,0.0973823,0.15503,0.0154015,0.193653,0.137219,0.228144,0.251466,0.288096,0.11903,0.0838874,0.331451,0.113145,0.112651,0.186638,0.174776,0.0948451,0.264079,0.249049,0.140533,0.0997756,0.257598,0.103667,0.113069,0.025556,0.16791,0.09066,0.585505,0.166967,0.188651,0.0813902,0.184948,0.156261,0.311847,0.511859,0.0590944,0.247324,0.178389,0.218229,0.231073,0.407281,0.0743925,0.0360851,0.0168763,0.131093,0.0434602,0.133616,0.418146,0.0785808,0.449036,0.407369,0.231447,0.544776,0.43956,0.37006,0.42622,0.022688,0.197484,0.396996,0.36145,0.0966095,0.381071,0.216033,0.643768,0.000302291,0.00207232,0.390366,6.6846e-06,0.50058,0.443185,0.169835,0.875915,0.871256,0.227104,0.518585,0.0734371,0.38649,0.284625,0.504757,0.04783,0.0108655,0.28907,0.164197,0.462688,0.287881,0.574635,0.00445792,0.336276,0.468444,0.258219,0.446557,0.243383,0.0186777,0.390974,0.382874,0.683217,0.161598,0.00310283,0.277094,0.0323708,0.0239796,0.37357,0.0704414,0.477353,0.452741,0.00292516,0.771991,0.20342,0.200493,0.00171127,0.300504,0.25656,0.425963,0.349197,0.383291,0.156104,0.141318,0.000226517,0.0961477,0.314438,0.354789,0.163828,0.230581,0.120226,0.28424,0.562405,0.314429,0.181415,0.00475227,0.194707,0.0727621,0.408413,0.165147,0.322213,0.0234043,0.33942,0.61031,0.387276,0.0391112,0.802166,0.180745,0.222037,0.416621,0.416292,0.0252635,0.734551,0.579431,0.204817,0.452428,0.138871,0.308032,0.166905,0.19783,0.0833851,0.316453,0.140384,0.175199,0.332919,0.373557,0.523625,0.408861,0.365487,0.534741,0.39088,0.363192,0.236011,0.203486,0.273398,0.000131088,0.119167,0.00977892,0.275347,0.637444,0.305885,0.241132,0.371414,0.30666,0.0516603,0.0323359,0.000154868,0.159081,0.250964,0.383276,0.457886,0.504711,0.220231,0.509064,0.196976,0.191517,0.0254647,0.601877,0.307334,0.459728,0.283463,0.563586,0.472935,0.399569,0.273281,0.368095,0.275089,0.0858306,0.47795,0.359231,0.339729,0.197805,0.0690807,0.387069,0.332774,0.52832,0.299887,0.0193657,0.205413,0.17639,0.0779009,0.276869,0.205298,0.0337138,0.18966,0.258854,0.188263,0.0719199,0.264884,0.162568,0.19104,0.0140817,0.219428,0.208013,0.0900729,0.0953646,0.166124,0.252184,0.378361,0.255516,0.20753,0.447185,0.179412,0.193601,0.0264253,0.222977,0.341681,0.310674,0.21801,0.198614,0.186804,0.123324,0.199468,5.91485e-06,0.0933115,0.12405,0.179889,0.226869,0.27872,0.0855609,0.131118,0.0233967,0.247588,0.222339,0.0673329,0.20847,0.0391817,0.113092,0.145701,0.229428,0.162145,0.228955,0.168748,0.0384949,0.0660995,0.0521984,0.0455518,0.268741,0.201602,0.350452,0.154941,0.120196,0.0986735,0.108462,0.0595618,0.21593,0.0132793,0.220319,0.195218,0.124213,0.000267844,0.30793,0.180606,0.159884,0.0363723,0.150733,0.217112,0.123917,0.184317,0.185335,0.0723291,0.0367308,0.261744,0.203781,0.21382,0.207559,0.141867,0.193031,0.249101,0.115972,0.224568,0.246105,0.000991755,0.200432,0.139785,0.197112,0.00282612,0.156465,0.13108,0.00350063,0.222798,0.172134,0.176789,0.0969345,0.202137,0.310405,0.00467879,0.218161,0.00347819,0.202065,0.106739,0.0536053,0.0537737,0.15113,0.078016,0.0407233,0.0537355,0.0577193,0.261724,0.211332,0.018841,0.233626,0.189559,0.0812887,0.0981146,0.064145,0.121913,0.0638699,0.104603,0.0663259,0.0762523,0.128736,0.109171,0.04411,0.066952,0.089609,0.0367455,0.13497,0.204393,0.295769,0.286691,0.347036,0.141729,0.263159,0.255956,0.200105,0.227491,0.29837,0.253509,0.177664,0.28365,0.264413,0.131761,0.160658,0.206239,0.19924,0.28689,0.236464,0.325148,0.115817,0.218052,0.223831,0.11528,0.194982,0.190993,0.281727,0.283218,0.249955,0.164638,0.224257,0.0935776,0.327622,0.225752,0.207791,0.0958756,0.0859274,0.316866,0.171683,0.158847,0.271275,0.071111,0.270604,0.101021,0.222548,0.1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}}
}}

Revision as of 15:41, 19 October 2012


Full id: C4117_Urothelial_small_Corneal_tubular_Smooth_cervical_pharyngeal



Phase1 CAGE Peaks

Hg19::chr2:110873370..110873379,-p3@MALL
Hg19::chr2:110873388..110873405,-p1@MALL
Hg19::chr2:110873422..110873434,-p2@MALL


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
anatomical cluster2.81e-24373
anatomical system7.41e-23624
anatomical group1.46e-22625
anatomical conduit4.97e-22240
epithelium9.14e-22306
multi-cellular organism3.05e-21656
cell layer3.76e-21309
epithelial tube2.48e-17117
organism subdivision1.23e-16264
multi-tissue structure5.85e-16342
tube1.51e-15192
trunk2.46e-15199
vessel1.27e-1368
organ part4.20e-13218
splanchnic layer of lateral plate mesoderm4.48e-1383
vasculature9.14e-1378
vascular system9.14e-1378
anatomical space2.10e-1295
compound organ2.15e-1268
epithelial tube open at both ends3.27e-1259
blood vessel3.27e-1259
blood vasculature3.27e-1259
vascular cord3.27e-1259
simple squamous epithelium7.66e-1222
embryo1.27e-11592
endoderm-derived structure1.31e-11160
endoderm1.31e-11160
presumptive endoderm1.31e-11160
organ1.36e-11503
trunk region element3.46e-11101
renal system5.29e-1148
squamous epithelium7.24e-1125
urinary system structure7.86e-1147
developing anatomical structure8.48e-11581
blood vessel endothelium3.99e-1018
endothelium3.99e-1018
cardiovascular system endothelium3.99e-1018
subdivision of trunk4.88e-10112
immaterial anatomical entity6.28e-10117
unilaminar epithelium2.43e-09148
subdivision of digestive tract6.71e-09118
digestive system7.47e-09145
digestive tract7.47e-09145
primitive gut7.47e-09145
embryonic structure9.40e-09564
nephron epithelium1.10e-0815
renal tubule1.10e-0815
nephron tubule1.10e-0815
nephron1.10e-0815
uriniferous tubule1.10e-0815
nephrogenic mesenchyme1.10e-0815
circulatory system1.14e-08112
epithelial fold1.49e-0847
excretory tube1.63e-0816
kidney epithelium1.63e-0816
germ layer3.26e-08560
germ layer / neural crest3.26e-08560
embryonic tissue3.26e-08560
presumptive structure3.26e-08560
germ layer / neural crest derived structure3.26e-08560
epiblast (generic)3.26e-08560
cardiovascular system3.39e-08109
thoracic segment organ3.39e-0835
thoracic segment of trunk3.68e-0852
thoracic cavity element4.53e-0834
thoracic cavity4.53e-0834
intermediate mesoderm6.59e-0828
mesenchyme7.07e-08160
entire embryonic mesenchyme7.07e-08160
duct1.24e-0719
epithelial bud2.06e-0737
cortex of kidney2.96e-0712
renal parenchyma2.96e-0712
parenchyma3.16e-0715
tracheobronchial tree3.76e-0715
lower respiratory tract3.76e-0715
artery8.09e-0742
arterial blood vessel8.09e-0742
arterial system8.09e-0742
endo-epithelium8.27e-0782


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0280021133119857
E2F1#186934.907389214879320.008460985347239390.0326060606132738
ESR1#2099330.76860329615453.43136389821584e-050.00067795727235294
MYC#460935.22228187160940.007020843755740150.0295070382698489



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.