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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.0724992894770213

Latest revision as of 11:56, 17 September 2013


Full id: C2008_immature_migratory_CD14CD16_CD14_leukemia_mesothelioma_temporal



Phase1 CAGE Peaks

Hg19::chr8:125740643..125740697,-p1@MTSS1
Hg19::chr8:125740699..125740720,-p2@MTSS1
Hg19::chr8:125740730..125740741,-p3@MTSS1
Hg19::chr8:125740876..125740886,-p6@MTSS1
Hg19::chr8:125740895..125740906,-p4@MTSS1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte4.60e-2242
CD14-positive, CD16-negative classical monocyte4.60e-2242
defensive cell6.08e-2248
phagocyte6.08e-2248
granulocyte monocyte progenitor cell7.49e-2067
myeloid lineage restricted progenitor cell8.29e-1966
macrophage dendritic cell progenitor2.01e-1861
myeloid leukocyte6.95e-1872
monopoietic cell3.38e-1759
monocyte3.38e-1759
monoblast3.38e-1759
promonocyte3.38e-1759
myeloid cell8.16e-14108
common myeloid progenitor8.16e-14108
leukocyte8.86e-14136
hematopoietic lineage restricted progenitor cell2.58e-12120
nongranular leukocyte3.92e-11115
stuff accumulating cell1.02e-1087
hematopoietic oligopotent progenitor cell4.01e-10161
hematopoietic multipotent progenitor cell4.01e-10161
hematopoietic stem cell4.80e-10168
angioblastic mesenchymal cell4.80e-10168
hematopoietic cell3.68e-09177
intermediate monocyte2.16e-079
CD14-positive, CD16-positive monocyte2.16e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system7.75e-1998
blood island7.75e-1998
hemolymphoid system1.41e-17108
bone marrow3.17e-1676
adult organism7.67e-16114
bone element5.89e-1582
immune system1.26e-1493
skeletal element1.48e-1290
developing anatomical structure1.50e-10581
skeletal system3.16e-10100
embryonic structure4.05e-10564
germ layer6.96e-10560
germ layer / neural crest6.96e-10560
embryonic tissue6.96e-10560
presumptive structure6.96e-10560
germ layer / neural crest derived structure6.96e-10560
epiblast (generic)6.96e-10560
embryo1.12e-09592
tissue3.55e-09773
neural tube5.13e-0956
neural rod5.13e-0956
future spinal cord5.13e-0956
neural keel5.13e-0956
regional part of nervous system1.33e-0853
regional part of brain1.33e-0853
lateral plate mesoderm1.46e-07203
regional part of forebrain2.02e-0741
forebrain2.02e-0741
anterior neural tube2.02e-0741
future forebrain2.02e-0741
anatomical system3.65e-07624
anatomical group5.90e-07625


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.80249
MA0004.10.626788
MA0006.14.0459
MA0007.10.606704
MA0009.11.11255
MA0014.10.660087
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.11.08193
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.11.01397
MA0056.10
MA0057.10.554727
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.11.00065
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.11.25946
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.11.99092
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.11.35428
MA0147.17.01805
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.21.12758
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.27.50045
MA0047.20.767096
MA0112.24.17482
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.98952
MA0155.10.409315
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.81299
MA0163.10.168633
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.21.03616
MA0102.21.66336
MA0258.10.345771
MA0259.12.71109
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186954.907389214879320.0003512818099256460.00353546506185068
MYC#460955.22228187160940.0002573944848850610.00276820333713427
TAF1#687253.343046285745290.002394600090870310.0135571984003038



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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