MCL coexpression mm9:3045

Phase1 CAGE Peaks

	Short description
Mm9::chr16:37916526..37916560,+	p1@Gpr156
Mm9::chr18:46372105..46372115,-	p5@Trim36
Mm9::chr18:46372223..46372244,-	p4@Trim36

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004965	GABA-B receptor activity	0.0197217047134236
GO:0007340	acrosome reaction	0.0306571960125222
GO:0017156	calcium ion-dependent exocytosis	0.0306571960125222
GO:0001669	acrosome	0.0306571960125222
GO:0008067	metabotropic glutamate, GABA-B-like receptor activity	0.0306571960125222
GO:0016917	GABA receptor activity	0.0306571960125222
GO:0007338	single fertilization	0.0357461375881951
GO:0008066	glutamate receptor activity	0.0357461375881951
GO:0009566	fertilization	0.0357461375881951

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	2.57e-14	23
neuroblast (sensu Vertebrata)	2.57e-14	23
neuron	7.21e-10	33
neuronal stem cell	7.21e-10	33
neuroblast	7.21e-10	33
electrically signaling cell	7.21e-10	33
ectodermal cell	1.53e-09	44
neurectodermal cell	1.53e-09	44
neural cell	8.19e-09	43
electrically responsive cell	3.14e-07	39
electrically active cell	3.14e-07	39
neuron of cerebral cortex	3.52e-07	6
non-terminally differentiated cell	9.46e-07	49

Uber Anatomy

Ontology term	p-value	n
pre-chordal neural plate	6.28e-13	49
ectoderm-derived structure	9.60e-13	95
ectoderm	9.60e-13	95
presumptive ectoderm	9.60e-13	95
neurectoderm	2.42e-12	64
neural plate	2.42e-12	64
presumptive neural plate	2.42e-12	64
ecto-epithelium	6.07e-12	73
sense organ	2.02e-10	12
sensory system	2.02e-10	12
entire sense organ system	2.02e-10	12
head	2.61e-09	13
nervous system	6.07e-09	75
structure with developmental contribution from neural crest	1.44e-08	92
neural tube	2.36e-08	52
neural rod	2.36e-08	52
future spinal cord	2.36e-08	52
neural keel	2.36e-08	52
regional part of nervous system	3.02e-08	54
central nervous system	4.34e-08	73
eye	5.55e-08	9
camera-type eye	5.55e-08	9
simple eye	5.55e-08	9
immature eye	5.55e-08	9
ocular region	5.55e-08	9
visual system	5.55e-08	9
face	5.55e-08	9
optic cup	5.55e-08	9
optic vesicle	5.55e-08	9
eye primordium	5.55e-08	9
ectodermal placode	6.00e-08	13
anterior neural tube	1.47e-07	40
subdivision of head	2.52e-07	11
regional part of forebrain	3.93e-07	39
forebrain	3.93e-07	39
future forebrain	3.93e-07	39

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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