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Coexpression cluster:C3056: Difference between revisions

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|tf_chipseq_enrich=EP300#2033;3:6.7739417262232:0.00321688050010379:0.0166824461269348
|tf_chipseq_enrich=EP300#2033;3:6.7739417262232:0.00321688050010379:0.0166824461269348
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}}
}}

Revision as of 15:54, 26 November 2012


Full id: C3056_epidermoid_Renal_anaplastic_clear_Iris_ductal_Retinal



Phase1 CAGE Peaks

Hg19::chr10:91043420..91043437,+p1@ENST00000444849
Hg19::chr10:91043443..91043456,+p2@ENST00000444849
Hg19::chr10:91043477..91043497,+p1@ENST00000354541


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
kidney4.06e-1626
kidney mesenchyme4.06e-1626
upper urinary tract4.06e-1626
kidney rudiment4.06e-1626
kidney field4.06e-1626
excretory tube5.58e-1316
kidney epithelium5.58e-1316
nephron tubule epithelium8.13e-1310
cavitated compound organ1.41e-1231
nephron epithelium8.74e-1215
renal tubule8.74e-1215
nephron tubule8.74e-1215
nephron8.74e-1215
uriniferous tubule8.74e-1215
nephrogenic mesenchyme8.74e-1215
pigment epithelium of eye1.12e-1111
cortex of kidney2.79e-1012
renal parenchyma2.79e-1012
urinary system structure3.83e-1047
renal system8.48e-1048
eye6.63e-0921
visual system6.63e-0921
sense organ8.69e-0924
sensory system8.69e-0924
entire sense organ system8.69e-0924
camera-type eye4.64e-0820
simple eye4.64e-0820
immature eye4.64e-0820
ocular region4.64e-0820
eyeball of camera-type eye4.64e-0820
optic cup4.64e-0820
optic vesicle4.64e-0820
eye primordium4.64e-0820
cortex9.60e-0815
parenchyma9.60e-0815
atypical epithelium1.28e-074
abdominal segment of trunk2.92e-0760
abdomen2.92e-0760
face4.68e-0722
Disease
Ontology termp-valuen
female reproductive endometrioid cancer3.74e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203336.77394172622320.003216880500103790.0166824461269348



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.