Coexpression cluster:C4327

Full id: C4327_Mast_heart_spleen_aorta_penis_thyroid_CD34

Phase1 CAGE Peaks

Hg19::chr3:37493590..37493607,+	p2@ITGA9
Hg19::chr3:37493612..37493651,+	p1@ITGA9
Hg19::chr3:37493675..37493680,+	p3@ITGA9

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	3.37e-49	115
neural tube	8.62e-23	57
neural rod	8.62e-23	57
future spinal cord	8.62e-23	57
neural keel	8.62e-23	57
central nervous system	2.88e-19	82
anterior neural tube	1.11e-18	42
regional part of forebrain	4.58e-18	41
forebrain	4.58e-18	41
future forebrain	4.58e-18	41
regional part of brain	1.93e-17	59
regional part of nervous system	1.12e-16	94
nervous system	1.12e-16	94
brain	2.12e-15	69
future brain	2.12e-15	69
telencephalon	2.25e-15	34
gray matter	3.81e-15	34
brain grey matter	3.81e-15	34
regional part of telencephalon	7.53e-15	33
cerebral hemisphere	1.43e-14	32
neural plate	4.75e-14	86
presumptive neural plate	4.75e-14	86
neurectoderm	8.94e-13	90
cerebral cortex	1.27e-11	25
pallium	1.27e-11	25
regional part of cerebral cortex	1.94e-11	22
neocortex	1.77e-10	20
pre-chordal neural plate	4.97e-09	61
multi-cellular organism	4.11e-08	659
organ	2.89e-07	511

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0190648587277783
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0280542479871632
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0321701993722114
GATA2#2624	3	12.744931733554	0.000482952770428379	0.00438029564835167
RAD21#5885	3	10.3550338954563	0.000900491207356542	0.00666570282834431
SMC3#9126	3	15.0449328449328	0.000293582542037187	0.00310087652789459
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0140622456010284

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.