Coexpression cluster:C2784

Full id: C2784_Mast_vagina_CD14_liver_medulla_thalamus_substantia

Phase1 CAGE Peaks

Hg19::chr4:1713506..1713523,+	p@chr4:1713506..1713523 +
Hg19::chr6:31789994..31790022,+	p@chr6:31789994..31790022 +
Hg19::chr6:31795013..31795063,-	p@chr6:31795013..31795063 -
Hg19::chr6:31795123..31795151,-	p@chr6:31795123..31795151 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
classical monocyte	4.56e-15	42
CD14-positive, CD16-negative classical monocyte	4.56e-15	42
myeloid lineage restricted progenitor cell	2.36e-13	66
defensive cell	3.15e-13	48
phagocyte	3.15e-13	48
granulocyte monocyte progenitor cell	3.48e-12	67
monopoietic cell	1.77e-11	59
monocyte	1.77e-11	59
monoblast	1.77e-11	59
promonocyte	1.77e-11	59
macrophage dendritic cell progenitor	1.13e-10	61
myeloid leukocyte	2.45e-10	72
myeloid cell	3.37e-07	108
common myeloid progenitor	3.37e-07	108

Uber Anatomy

Ontology term	p-value	n
adult organism	5.28e-34	114
neural tube	3.09e-15	56
neural rod	3.09e-15	56
future spinal cord	3.09e-15	56
neural keel	3.09e-15	56
regional part of nervous system	2.22e-14	53
regional part of brain	2.22e-14	53
regional part of forebrain	4.86e-12	41
forebrain	4.86e-12	41
anterior neural tube	4.86e-12	41
future forebrain	4.86e-12	41
brain	1.88e-11	68
future brain	1.88e-11	68
central nervous system	2.01e-11	81
bone marrow	2.22e-10	76
neural plate	1.04e-09	82
presumptive neural plate	1.04e-09	82
bone element	1.61e-09	82
immune system	2.24e-09	93
hematopoietic system	2.46e-09	98
blood island	2.46e-09	98
neurectoderm	2.68e-09	86
nervous system	2.94e-09	89
brain grey matter	4.27e-09	34
gray matter	4.27e-09	34
telencephalon	4.43e-09	34
organ	1.44e-08	503
hemolymphoid system	4.27e-08	108
regional part of telencephalon	4.89e-08	32
skeletal element	7.21e-08	90
cerebral hemisphere	9.03e-08	32
ecto-epithelium	4.53e-07	104

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
EBF1#1879	3	6.67985013492675	0.00518429411827891	0.0240587644265244
EP300#2033	3	5.0804562946674	0.0114429840539824	0.0419110577455327
GTF2B#2959	3	23.9578724507432	0.000119775456285592	0.00162499725630176
GTF2F1#2962	3	9.55474565756824	0.00182036231930478	0.0109011938225844
HSF1#3297	3	123.218	8.95545257123937e-07	3.85690107665018e-05
IRF1#3659	3	5.72787281517293	0.00809711479033333	0.0320178165829026
MXI1#4601	3	7.47117872156947	0.00374131473855096	0.0186403573122566
NR2C2#7182	2	16.3073054526204	0.00541182534464822	0.0245592086195236
PBX3#5090	2	10.9572563433721	0.0117453018068803	0.0428605022854219
PPARGC1A#10891	2	175.025568181818	4.86875556353338e-05	0.000845366520864277
SIRT6#51548	2	76.8192019950125	0.000251781005061704	0.00271146178466069
SP2#6668	2	13.0767652469223	0.00833003653661494	0.0328121251356841
STAT1#6772	2	10.3532937485996	0.0131077747617126	0.0464953601310499
STAT2#6773	3	48.9478283898305	1.42094046481278e-05	0.000340526849941674
STAT3#6774	3	7.88959874786568	0.00319076048168013	0.0167448788476052

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.