Coexpression cluster:C376

Full id: C376_brain_temporal_insula_frontal_occipital_postcentral_paracentral

Phase1 CAGE Peaks

Hg19::chr11:20690677..20690691,+	p4@NELL1
Hg19::chr11:70672700..70672711,-	p21@SHANK2
Hg19::chr15:52043722..52043735,-	p7@LYSMD2
Hg19::chr15:75249573..75249587,-	p12@RPP25
Hg19::chr15:77988485..77988494,-	p27@LINGO1
Hg19::chr16:2230120..2230121,-	p@chr16:2230120..2230121 -
Hg19::chr16:57406456..57406465,+	p3@CX3CL1
Hg19::chr19:12945382..12945400,-	p2@RTBDN
Hg19::chr19:12945478..12945499,-	p6@RTBDN
Hg19::chr19:18311186..18311201,+	p@chr19:18311186..18311201 +
Hg19::chr19:40724239..40724242,-	p3@TTC9B
Hg19::chr19:42482880..42482902,+	p@chr19:42482880..42482902 +
Hg19::chr19:46296190..46296207,-	p4@DMWD
Hg19::chr19:822429..822477,-	p4@MIR3187
Hg19::chr1:155291286..155291312,+	p10@RUSC1
Hg19::chr20:36560066..36560087,-	p@chr20:36560066..36560087 -
Hg19::chr2:73511460..73511470,-	p8@FBXO41
Hg19::chr2:74757308..74757330,+	p6@HTRA2
Hg19::chr3:68053515..68053522,+	p5@FAM19A1
Hg19::chr4:150999349..150999359,+	p13@DCLK2
Hg19::chr4:6564686..6564690,-	p@chr4:6564686..6564690 -
Hg19::chr5:112043148..112043155,+	p14@APC
Hg19::chr5:63257007..63257019,-	p7@HTR1A
Hg19::chr6:33395473..33395504,+	p1@AK124666
Hg19::chr7:45613934..45613945,+	p4@ADCY1
Hg19::chr8:10158713..10158718,+	p22@MSRA
Hg19::chr8:4852171..4852180,-	p14@CSMD1
Hg19::chr9:139872612..139872634,+	p@chr9:139872612..139872634 +
Hg19::chr9:34957921..34957934,+	p7@KIAA1045

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0051983	regulation of chromosome segregation	0.0315259625574002
GO:0051041	positive regulation of calcium-independent cell-cell adhesion	0.0315259625574002
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	0.0315259625574002
GO:0050902	leukocyte adhesive activation	0.0315259625574002
GO:0051040	regulation of calcium-independent cell-cell adhesion	0.0315259625574002
GO:0008608	attachment of spindle microtubules to kinetochore	0.0315259625574002

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	3.71e-38	94
nervous system	3.71e-38	94
central nervous system	1.92e-36	82
neural tube	4.56e-30	57
neural rod	4.56e-30	57
future spinal cord	4.56e-30	57
neural keel	4.56e-30	57
brain	1.09e-29	69
future brain	1.09e-29	69
adult organism	7.78e-29	115
neurectoderm	3.90e-28	90
regional part of brain	1.87e-27	59
neural plate	6.91e-27	86
presumptive neural plate	6.91e-27	86
ectoderm	1.81e-24	173
presumptive ectoderm	1.81e-24	173
ectoderm-derived structure	2.94e-23	169
regional part of forebrain	5.99e-23	41
forebrain	5.99e-23	41
future forebrain	5.99e-23	41
anterior neural tube	2.92e-22	42
telencephalon	4.39e-19	34
gray matter	5.05e-19	34
brain grey matter	5.05e-19	34
head	8.79e-19	123
anterior region of body	9.07e-19	129
craniocervical region	9.07e-19	129
regional part of telencephalon	2.08e-18	33
cerebral hemisphere	3.81e-18	32
pre-chordal neural plate	4.04e-18	61
regional part of cerebral cortex	4.99e-14	22
cerebral cortex	5.61e-14	25
pallium	5.61e-14	25
neocortex	8.25e-13	20
tube	1.92e-09	194
posterior neural tube	6.66e-09	15
chordal neural plate	6.66e-09	15
anatomical cluster	1.45e-08	286
anatomical conduit	1.60e-08	241
organism subdivision	2.93e-08	365
organ part	4.02e-08	219
segmental subdivision of nervous system	8.50e-08	13
segmental subdivision of hindbrain	2.69e-07	12
hindbrain	2.69e-07	12
presumptive hindbrain	2.69e-07	12
epithelium	3.29e-07	309
cell layer	5.49e-07	312

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.