Coexpression cluster:C209

Full id: C209_acute_myelodysplastic_CD34_granulocyte_CD133_liver_spleen

Phase1 CAGE Peaks

Hg19::chr17:56347341..56347343,-	p@chr17:56347341..56347343 -
Hg19::chr17:56347391..56347426,-	p@chr17:56347391..56347426 -
Hg19::chr17:56347979..56347991,-	p@chr17:56347979..56347991 -
Hg19::chr17:56348026..56348034,-	p@chr17:56348026..56348034 -
Hg19::chr17:56349073..56349082,-	p@chr17:56349073..56349082 -
Hg19::chr17:56349229..56349239,-	p@chr17:56349229..56349239 -
Hg19::chr17:56350797..56350801,-	p@chr17:56350797..56350801 -
Hg19::chr17:56351008..56351018,-	p@chr17:56351008..56351018 -
Hg19::chr17:56352942..56352955,-	p@chr17:56352942..56352955 -
Hg19::chr17:56352974..56352992,-	p@chr17:56352974..56352992 -
Hg19::chr17:56353028..56353052,-	p@chr17:56353028..56353052 -
Hg19::chr17:56353056..56353065,-	p@chr17:56353056..56353065 -
Hg19::chr17:56355298..56355312,-	p@chr17:56355298..56355312 -
Hg19::chr17:56355359..56355366,+	p@chr17:56355359..56355366 +
Hg19::chr17:56355384..56355414,-	p@chr17:56355384..56355414 -
Hg19::chr17:56355392..56355416,+	p@chr17:56355392..56355416 +
Hg19::chr17:56355416..56355433,-	p@chr17:56355416..56355433 -
Hg19::chr17:56356430..56356441,-	p@chr17:56356430..56356441 -
Hg19::chr17:56356444..56356472,+	p@chr17:56356444..56356472 +
Hg19::chr17:56356466..56356479,-	p@chr17:56356466..56356479 -
Hg19::chr17:56356480..56356490,-	p@chr17:56356480..56356490 -
Hg19::chr17:56356498..56356520,-	p@chr17:56356498..56356520 -
Hg19::chr17:56356521..56356550,-	p@chr17:56356521..56356550 -
Hg19::chr17:56356555..56356562,-	p@chr17:56356555..56356562 -
Hg19::chr17:56356677..56356692,-	p@chr17:56356677..56356692 -
Hg19::chr17:56356693..56356700,-	p@chr17:56356693..56356700 -
Hg19::chr17:56356703..56356737,-	p@chr17:56356703..56356737 -
Hg19::chr17:56356710..56356716,+	p@chr17:56356710..56356716 +
Hg19::chr17:56356745..56356760,-	p@chr17:56356745..56356760 -
Hg19::chr17:56356761..56356775,-	p@chr17:56356761..56356775 -
Hg19::chr17:56356913..56356926,-	p@chr17:56356913..56356926 -
Hg19::chr17:56356934..56356952,-	p@chr17:56356934..56356952 -
Hg19::chr17:56356957..56356966,-	p@chr17:56356957..56356966 -
Hg19::chr17:56356979..56356990,-	p@chr17:56356979..56356990 -
Hg19::chr17:56356998..56357013,-	p@chr17:56356998..56357013 -
Hg19::chr17:56357123..56357132,-	p@chr17:56357123..56357132 -
Hg19::chr17:56357160..56357171,-	p@chr17:56357160..56357171 -
Hg19::chr17:56357176..56357192,-	p@chr17:56357176..56357192 -
Hg19::chr17:56357207..56357223,-	p@chr17:56357207..56357223 -
Hg19::chr17:56357236..56357244,-	p@chr17:56357236..56357244 -
Hg19::chr17:56357251..56357269,-	p@chr17:56357251..56357269 -
Hg19::chr17:56357272..56357293,-	p@chr17:56357272..56357293 -
Hg19::chr17:56357304..56357313,-	p@chr17:56357304..56357313 -
Hg19::chr17:56357324..56357333,-	p@chr17:56357324..56357333 -
Hg19::chr17:56357337..56357342,-	p@chr17:56357337..56357342 -
Hg19::chr17:56357347..56357357,-	p@chr17:56357347..56357357 -
Hg19::chr17:56357390..56357401,-	p@chr17:56357390..56357401 -
Hg19::chr17:56357785..56357813,-	p@chr17:56357785..56357813 -
Hg19::chr17:56358047..56358058,-	p3@MPO
Hg19::chr17:56358092..56358104,-	p2@MPO
Hg19::chr17:56358287..56358302,-	p1@MPO
Hg19::chr17:76122653..76122662,-	p@chr17:76122653..76122662 -
Hg19::chr19:840991..841006,+	p1@PRTN3
Hg19::chr19:843490..843500,+	p5@PRTN3
Hg19::chr19:843540..843551,+	p3@PRTN3
Hg19::chr19:843564..843580,+	p2@PRTN3
Hg19::chr19:843883..843896,+	p@chr19:843883..843896 +
Hg19::chr19:843899..843953,+	p@chr19:843899..843953 +
Hg19::chr19:843957..843983,+	p@chr19:843957..843983 +
Hg19::chr19:846248..846259,+	p@chr19:846248..846259 +
Hg19::chr19:847897..847908,+	p@chr19:847897..847908 +
Hg19::chr19:847948..847965,+	p@chr19:847948..847965 +
Hg19::chr19:847992..847997,+	p@chr19:847992..847997 +
Hg19::chr19:848054..848078,-	p@chr19:848054..848078 -
Hg19::chr19:848125..848141,+	p@chr19:848125..848141 +
Hg19::chr19:852295..852310,+	p1@ELANE
Hg19::chr19:855581..855593,+	p4@ELANE
Hg19::chr19:856103..856124,-	p@chr19:856103..856124 -
Hg19::chr19:856179..856196,+	p@chr19:856179..856196 +
Hg19::chr1:162934104..162934106,-	p@chr1:162934104..162934106 -
Hg19::chr22:34197370..34197374,-	p@chr22:34197370..34197374 -
Hg19::chr3:74072773..74072775,+	p@chr3:74072773..74072775 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042744	hydrogen peroxide catabolic process	0.00926961244116411
GO:0042743	hydrogen peroxide metabolic process	0.00926961244116411
GO:0009056	catabolic process	0.00926961244116411
GO:0030574	collagen catabolic process	0.00926961244116411
GO:0044256	protein digestion	0.00926961244116411
GO:0044254	multicellular organismal protein catabolic process	0.00926961244116411
GO:0044266	multicellular organismal macromolecule catabolic process	0.00926961244116411
GO:0044259	multicellular organismal macromolecule metabolic process	0.00926961244116411
GO:0042542	response to hydrogen peroxide	0.00926961244116411
GO:0044268	multicellular organismal protein metabolic process	0.00926961244116411
GO:0044243	multicellular organismal catabolic process	0.00926961244116411
GO:0032963	collagen metabolic process	0.00926961244116411
GO:0044236	multicellular organismal metabolic process	0.00937120036595884
GO:0000302	response to reactive oxygen species	0.0102145888597069
GO:0006800	oxygen and reactive oxygen species metabolic process	0.0158851492391733
GO:0004601	peroxidase activity	0.0208619636819112
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	0.0208619636819112
GO:0007586	digestion	0.0279255164146127
GO:0003682	chromatin binding	0.0317352050678504
GO:0006979	response to oxidative stress	0.0317352050678504
GO:0006916	anti-apoptosis	0.0427857746694047
GO:0005764	lysosome	0.0455677970498542
GO:0000323	lytic vacuole	0.0455677970498542
GO:0043066	negative regulation of apoptosis	0.0455677970498542
GO:0043069	negative regulation of programmed cell death	0.0455677970498542
GO:0005773	vacuole	0.0455677970498542
GO:0008284	positive regulation of cell proliferation	0.0455677970498542

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
myeloid cell	8.65e-30	112
common myeloid progenitor	8.65e-30	112
myeloid leukocyte	2.39e-25	76
monopoietic cell	2.23e-24	63
monocyte	2.23e-24	63
monoblast	2.23e-24	63
promonocyte	2.23e-24	63
macrophage dendritic cell progenitor	1.55e-23	65
myeloid lineage restricted progenitor cell	1.75e-22	70
CD14-positive, CD16-negative classical monocyte	5.75e-22	42
granulocyte monocyte progenitor cell	3.60e-21	71
classical monocyte	6.73e-20	45
hematopoietic stem cell	1.21e-17	172
angioblastic mesenchymal cell	1.21e-17	172
hematopoietic oligopotent progenitor cell	7.84e-17	165
hematopoietic multipotent progenitor cell	7.84e-17	165
hematopoietic cell	4.47e-16	182
nongranular leukocyte	2.89e-11	119
leukocyte	3.39e-11	140
hematopoietic lineage restricted progenitor cell	7.56e-10	124

Uber Anatomy

Ontology term	p-value	n
adult organism	3.28e-38	115
hematopoietic system	6.48e-22	102
blood island	6.48e-22	102
hemolymphoid system	2.31e-20	112
bone marrow	9.32e-18	80
neural tube	8.22e-16	57
neural rod	8.22e-16	57
future spinal cord	8.22e-16	57
neural keel	8.22e-16	57
bone element	9.89e-15	86
regional part of forebrain	6.16e-13	41
forebrain	6.16e-13	41
future forebrain	6.16e-13	41
immune system	1.16e-12	115
regional part of brain	2.45e-12	59
anterior neural tube	2.82e-12	42
central nervous system	4.27e-11	82
skeletal element	4.96e-11	101
skeletal system	4.96e-11	101
telencephalon	7.53e-11	34
gray matter	1.27e-10	34
brain grey matter	1.27e-10	34
brain	2.05e-10	69
future brain	2.05e-10	69
regional part of telencephalon	2.27e-10	33
cerebral hemisphere	5.11e-10	32
neural plate	2.61e-09	86
presumptive neural plate	2.61e-09	86
regional part of cerebral cortex	2.95e-09	22
regional part of nervous system	1.03e-08	94
nervous system	1.03e-08	94
neocortex	1.29e-08	20
neurectoderm	4.55e-08	90
cerebral cortex	3.35e-07	25
pallium	3.35e-07	25
lateral plate mesoderm	5.04e-07	216

Disease

Ontology term	p-value	n
myeloid leukemia	3.27e-07	31

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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