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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.0698571209875989

Latest revision as of 12:09, 17 September 2013


Full id: C2604_Mast_occipital_parietal_temporal_duodenum_Neural_hepatoblastoma



Phase1 CAGE Peaks

Hg19::chr1:93913606..93913625,+p3@FNBP1L
Hg19::chr1:93913627..93913659,+p2@FNBP1L
Hg19::chr1:93913665..93913705,+p1@FNBP1L
Hg19::chr1:93913713..93913724,+p4@FNBP1L


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell5.79e-08253
Uber Anatomy
Ontology termp-valuen
organ system subdivision1.99e-21223
nervous system3.09e-2189
central nervous system4.79e-2081
anatomical cluster1.59e-19373
ectoderm-derived structure1.26e-17171
ectoderm1.26e-17171
presumptive ectoderm1.26e-17171
adult organism5.09e-17114
multi-cellular organism1.18e-14656
brain2.65e-1468
future brain2.65e-1468
neurectoderm4.58e-1486
neural tube8.89e-1456
neural rod8.89e-1456
future spinal cord8.89e-1456
neural keel8.89e-1456
neural plate4.70e-1382
presumptive neural plate4.70e-1382
regional part of nervous system1.60e-1253
regional part of brain1.60e-1253
ecto-epithelium1.74e-11104
regional part of forebrain9.55e-1141
forebrain9.55e-1141
anterior neural tube9.55e-1141
future forebrain9.55e-1141
multi-tissue structure8.23e-10342
embryo9.28e-10592
structure with developmental contribution from neural crest1.14e-09132
pre-chordal neural plate1.86e-0961
anatomical system1.88e-09624
brain grey matter1.95e-0934
gray matter1.95e-0934
anatomical group2.49e-09625
anatomical conduit4.69e-09240
organ7.81e-09503
regional part of telencephalon9.65e-0932
telencephalon1.07e-0834
cerebral hemisphere1.24e-0832
tube8.48e-08192
organ part2.10e-07218
developing anatomical structure3.27e-07581
epithelium6.25e-07306
Disease
Ontology termp-valuen
cell type cancer3.54e-16143
carcinoma3.85e-12106
germ cell and embryonal cancer3.82e-1122
germ cell cancer3.82e-1122


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.8989
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.13.08565
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.11.98521
MA0058.10.605914
MA0059.11.47051
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.214613
MA0074.11.91637
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.12.31225
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.11.29536
MA0105.11.22348
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.11.15856
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.21.5472
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.21.7213
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.13.02177
MA0160.10.756582
MA0161.10
MA0162.12.15942
MA0163.13.83423
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.210.6102
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187645.017155731697390.00157802193473060.00997560879131584
EGR1#195844.988179094810140.001615011500076050.0101498487216538
HEY1#2346244.040111043105710.00375304636917980.0186241760786263
RAD21#5885410.35503389545638.6948481184721e-050.00129503885146193
REST#597849.650028716128020.0001152825614219170.00157180097027984
TAF1#687243.343046285745290.008005664898701650.0322545959553855
TAF7#6879411.43306940492395.85061525419808e-050.000970200709007928
TBP#690843.706770687096390.005296377814784350.0244517904074911
ZNF263#1012748.221841637010680.0002187871180958320.00249153939884534



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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