Coexpression cluster:C2604

Full id: C2604_Mast_occipital_parietal_temporal_duodenum_Neural_hepatoblastoma

Phase1 CAGE Peaks

Hg19::chr1:93913606..93913625,+	p3@FNBP1L
Hg19::chr1:93913627..93913659,+	p2@FNBP1L
Hg19::chr1:93913665..93913705,+	p1@FNBP1L
Hg19::chr1:93913713..93913724,+	p4@FNBP1L

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	1.04e-08	254

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	4.13e-20	94
nervous system	4.13e-20	94
central nervous system	7.97e-20	82
ectoderm	9.76e-18	173
presumptive ectoderm	9.76e-18	173
adult organism	1.52e-17	115
ectoderm-derived structure	1.09e-16	169
multi-cellular organism	2.59e-15	659
neurectoderm	1.62e-14	90
brain	2.56e-14	69
future brain	2.56e-14	69
neural tube	8.88e-14	57
neural rod	8.88e-14	57
future spinal cord	8.88e-14	57
neural keel	8.88e-14	57
neural plate	1.87e-13	86
presumptive neural plate	1.87e-13	86
regional part of brain	2.35e-12	59
head	1.35e-11	123
embryo	1.63e-11	612
anterior region of body	6.13e-11	129
craniocervical region	6.13e-11	129
anterior neural tube	6.99e-11	42
regional part of forebrain	2.11e-10	41
forebrain	2.11e-10	41
future forebrain	2.11e-10	41
multi-tissue structure	6.08e-10	347
anatomical system	7.26e-10	625
anatomical conduit	8.22e-10	241
anatomical group	9.25e-10	626
pre-chordal neural plate	2.46e-09	61
embryonic structure	2.51e-09	605
developing anatomical structure	2.51e-09	605
gray matter	3.81e-09	34
brain grey matter	3.81e-09	34
germ layer	5.20e-09	604
embryonic tissue	5.20e-09	604
presumptive structure	5.20e-09	604
epiblast (generic)	5.20e-09	604
anatomical cluster	1.20e-08	286
regional part of telencephalon	1.69e-08	33
tube	1.83e-08	194
telencephalon	2.21e-08	34
cerebral hemisphere	2.44e-08	32
organism subdivision	2.93e-08	365
organ	5.33e-08	511
epithelium	9.18e-08	309
cell layer	1.36e-07	312
organ part	4.89e-07	219

Disease

Ontology term	p-value	n
cell type cancer	9.14e-17	143
carcinoma	1.20e-12	106
germ cell and embryonal cancer	2.76e-11	22
germ cell cancer	2.76e-11	22

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F6#1876	4	5.01715573169739	0.0015780219347306	0.00997560879131584
EGR1#1958	4	4.98817909481014	0.00161501150007605	0.0101498487216538
HEY1#23462	4	4.04011104310571	0.0037530463691798	0.0186241760786263
RAD21#5885	4	10.3550338954563	8.6948481184721e-05	0.00129503885146193
REST#5978	4	9.65002871612802	0.000115282561421917	0.00157180097027984
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0322545959553855
TAF7#6879	4	11.4330694049239	5.85061525419808e-05	0.000970200709007928
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0244517904074911
ZNF263#10127	4	8.22184163701068	0.000218787118095832	0.00249153939884534

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.