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Coexpression cluster:C2209: Difference between revisions

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|full_id=C2209_acute_testis_spinal_Endothelial_rectum_heart_substantia
|full_id=C2209_acute_testis_spinal_Endothelial_rectum_heart_substantia
|id=C2209
|id=C2209
|ontology_enrichment_celltype=CL:0002139!4.80e-18!24;CL:0000071!5.43e-17!18;CL:0002546!5.43e-17!18;CL:1000413!1.31e-12!9;CL:0000115!2.96e-10!35;CL:0002544!1.07e-08!6;CL:0002078!1.06e-07!44
|ontology_enrichment_celltype=CL:1000413!2.29e-19!9;CL:0002139!3.04e-17!24;CL:0000071!8.35e-16!18;CL:0002546!8.35e-16!18;CL:0002544!5.35e-13!6;CL:0000115!3.93e-10!36;CL:0002078!2.37e-07!45
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0007023!1.17e-47!115;UBERON:0001986!5.43e-17!18;UBERON:0004638!5.43e-17!18;UBERON:0004852!5.43e-17!18;UBERON:0001049!1.04e-16!57;UBERON:0005068!1.04e-16!57;UBERON:0006241!1.04e-16!57;UBERON:0007135!1.04e-16!57;UBERON:0004111!4.51e-16!241;UBERON:0003075!3.08e-15!86;UBERON:0007284!3.08e-15!86;UBERON:0002346!5.72e-14!90;UBERON:0000025!2.61e-13!194;UBERON:0000477!4.17e-13!286;UBERON:0000487!6.96e-13!22;UBERON:0003915!1.31e-12!9;UBERON:0004700!1.31e-12!9;UBERON:0001917!1.31e-12!9;UBERON:0005743!1.37e-12!86;UBERON:0002616!4.19e-12!59;UBERON:0000073!1.31e-11!94;UBERON:0001016!1.31e-11!94;UBERON:0001017!3.66e-11!82;UBERON:0006914!1.07e-10!25;UBERON:0003080!2.04e-10!42;UBERON:0000955!3.57e-10!69;UBERON:0006238!3.57e-10!69;UBERON:0002298!1.14e-09!8;UBERON:0002780!1.22e-09!41;UBERON:0001890!1.22e-09!41;UBERON:0006240!1.22e-09!41;UBERON:0000483!1.39e-08!309;UBERON:0000055!2.59e-08!69;UBERON:0000119!2.72e-08!312;UBERON:0003076!4.60e-08!15;UBERON:0003057!4.60e-08!15;UBERON:0003056!3.11e-07!61;UBERON:0000153!5.94e-07!129;UBERON:0007811!5.94e-07!129;UBERON:0001981!6.66e-07!60;UBERON:0007500!6.66e-07!60;UBERON:0004537!6.66e-07!60;UBERON:0006965!6.66e-07!60
|ontology_enrichment_uberon=UBERON:0007023!8.13e-41!114;UBERON:0003915!2.29e-19!9;UBERON:0004700!2.29e-19!9;UBERON:0001917!2.29e-19!9;UBERON:0004638!8.35e-16!18;UBERON:0001986!8.35e-16!18;UBERON:0004852!8.35e-16!18;UBERON:0001049!3.48e-15!56;UBERON:0005068!3.48e-15!56;UBERON:0006241!3.48e-15!56;UBERON:0007135!3.48e-15!56;UBERON:0003075!1.31e-13!82;UBERON:0007284!1.31e-13!82;UBERON:0004111!7.98e-13!240;UBERON:0002346!1.29e-12!86;UBERON:0000487!2.39e-12!22;UBERON:0000073!7.37e-12!53;UBERON:0002616!7.37e-12!53;UBERON:0000025!7.48e-12!192;UBERON:0001017!3.61e-11!81;UBERON:0000477!7.76e-11!373;UBERON:0010314!1.11e-10!132;UBERON:0006914!1.72e-10!25;UBERON:0001016!3.15e-10!89;UBERON:0010371!5.05e-10!104;UBERON:0003296!2.17e-09!4;UBERON:0010133!2.17e-09!4;UBERON:0002780!3.54e-09!41;UBERON:0001890!3.54e-09!41;UBERON:0003080!3.54e-09!41;UBERON:0006240!3.54e-09!41;UBERON:0000955!9.12e-09!68;UBERON:0006238!9.12e-09!68;UBERON:0000055!2.18e-08!68;UBERON:0003076!6.83e-08!15;UBERON:0003057!6.83e-08!15;UBERON:0001894!1.21e-07!7;UBERON:0006222!1.21e-07!7;UBERON:0001896!1.86e-07!3;UBERON:0005290!1.86e-07!3;UBERON:0010096!1.86e-07!3;UBERON:0002240!1.90e-07!3;UBERON:0005174!1.90e-07!3;UBERON:0001137!1.90e-07!3;UBERON:0007500!2.19e-07!59;UBERON:0001981!2.19e-07!59;UBERON:0004537!2.19e-07!59;UBERON:0006965!2.19e-07!59;UBERON:0003978!4.07e-07!3;UBERON:0009751!4.07e-07!3;UBERON:0000946!4.07e-07!3;UBERON:0002523!4.07e-07!3;UBERON:0005983!4.07e-07!3;UBERON:0002165!4.07e-07!3;UBERON:0002062!4.07e-07!3;UBERON:0007280!4.07e-07!3;UBERON:0004872!8.16e-07!83
|tf_chipseq_enrich=USF1#7391;3:4.77112445790597:0.0137046588718802:0.0482846158594033!ZBTB7A#51341;3:5.51393198090692:0.00903835282108109:0.0342310897258808
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926658,0.222091,0.0228412,0.0675312,0.00453107,0.343425,0.132374,0.285122,0.22741,0.203996,0.276721,0.321965,0.264707,0.121257
}}
}}

Revision as of 12:11, 19 October 2012


Full id: C2209_acute_testis_spinal_Endothelial_rectum_heart_substantia



Phase1 CAGE Peaks

Hg19::chr12:49488535..49488546,-p3@DHH
Hg19::chr12:49488554..49488568,-p2@DHH
Hg19::chr12:49488573..49488590,-p1@DHH
Hg19::chr19:2247294..2247304,+p@chr19:2247294..2247304
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism8.13e-41114
endothelial tube2.29e-199
arterial system endothelium2.29e-199
endothelium of artery2.29e-199
blood vessel endothelium8.35e-1618
endothelium8.35e-1618
cardiovascular system endothelium8.35e-1618
neural tube3.48e-1556
neural rod3.48e-1556
future spinal cord3.48e-1556
neural keel3.48e-1556
neural plate1.31e-1382
presumptive neural plate1.31e-1382
anatomical conduit7.98e-13240
neurectoderm1.29e-1286
simple squamous epithelium2.39e-1222
regional part of nervous system7.37e-1253
regional part of brain7.37e-1253
tube7.48e-12192
central nervous system3.61e-1181
anatomical cluster7.76e-11373
structure with developmental contribution from neural crest1.11e-10132
squamous epithelium1.72e-1025
nervous system3.15e-1089
ecto-epithelium5.05e-10104
gland of diencephalon2.17e-094
neuroendocrine gland2.17e-094
regional part of forebrain3.54e-0941
forebrain3.54e-0941
anterior neural tube3.54e-0941
future forebrain3.54e-0941
brain9.12e-0968
future brain9.12e-0968
vessel2.18e-0868
posterior neural tube6.83e-0815
chordal neural plate6.83e-0815
diencephalon1.21e-077
future diencephalon1.21e-077
medulla oblongata1.86e-073
myelencephalon1.86e-073
future myelencephalon1.86e-073
spinal cord1.90e-073
dorsal region element1.90e-073
dorsum1.90e-073
epithelial tube open at both ends2.19e-0759
blood vessel2.19e-0759
blood vasculature2.19e-0759
vascular cord2.19e-0759
valve4.07e-073
cardiac mesenchyme4.07e-073
cardial valve4.07e-073
tunica intima4.07e-073
heart layer4.07e-073
endocardium4.07e-073
endocardial cushion4.07e-073
presumptive endocardium4.07e-073
splanchnic layer of lateral plate mesoderm8.16e-0783


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
USF1#739134.771124457905970.01370465887188020.0482846158594033
ZBTB7A#5134135.513931980906920.009038352821081090.0342310897258808



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.