Coexpression cluster:C138
From FANTOM5_SSTAR
Full id: C138_diffuse_Burkitt_lymphangiectasia_lymphoma_acute_CD19_pineal
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0006468 | protein amino acid phosphorylation | 0.00792695412488815 |
| GO:0016310 | phosphorylation | 0.00792695412488815 |
| GO:0001932 | regulation of protein amino acid phosphorylation | 0.00792695412488815 |
| GO:0033238 | regulation of amine metabolic process | 0.00792695412488815 |
| GO:0006521 | regulation of amino acid metabolic process | 0.00792695412488815 |
| GO:0042325 | regulation of phosphorylation | 0.00841869775108913 |
| GO:0006793 | phosphorus metabolic process | 0.00841869775108913 |
| GO:0006796 | phosphate metabolic process | 0.00841869775108913 |
| GO:0051174 | regulation of phosphorus metabolic process | 0.00841869775108913 |
| GO:0019220 | regulation of phosphate metabolic process | 0.00841869775108913 |
| GO:0043126 | regulation of 1-phosphatidylinositol 4-kinase activity | 0.00841869775108913 |
| GO:0043128 | positive regulation of 1-phosphatidylinositol 4-kinase activity | 0.00841869775108913 |
| GO:0046813 | virion attachment, binding of host cell surface receptor | 0.00841869775108913 |
| GO:0031648 | protein destabilization | 0.0156319629705365 |
| GO:0018193 | peptidyl-amino acid modification | 0.0172743813151962 |
| GO:0043687 | post-translational protein modification | 0.0172743813151962 |
| GO:0018210 | peptidyl-threonine modification | 0.0172743813151962 |
| GO:0018107 | peptidyl-threonine phosphorylation | 0.0172743813151962 |
| GO:0019062 | virion attachment to host cell surface receptor | 0.0172743813151962 |
| GO:0007165 | signal transduction | 0.0191047159318527 |
| GO:0008593 | regulation of Notch signaling pathway | 0.0202675609349334 |
| GO:0005515 | protein binding | 0.0202675609349334 |
| GO:0007154 | cell communication | 0.0266769412154499 |
| GO:0006661 | phosphatidylinositol biosynthetic process | 0.0272081182847486 |
| GO:0006464 | protein modification process | 0.0272081182847486 |
| GO:0043550 | regulation of lipid kinase activity | 0.0294342336391061 |
| GO:0043412 | biopolymer modification | 0.0300437386506703 |
| GO:0005112 | Notch binding | 0.0300437386506703 |
| GO:0043621 | protein self-association | 0.0300437386506703 |
| GO:0018209 | peptidyl-serine modification | 0.0300437386506703 |
| GO:0018105 | peptidyl-serine phosphorylation | 0.0300437386506703 |
| GO:0044409 | entry into host | 0.0300437386506703 |
| GO:0045665 | negative regulation of neuron differentiation | 0.0300437386506703 |
| GO:0052192 | movement in environment of other organism during symbiotic interaction | 0.0300437386506703 |
| GO:0046718 | entry of virus into host cell | 0.0300437386506703 |
| GO:0030260 | entry into host cell | 0.0300437386506703 |
| GO:0019059 | initiation of viral infection | 0.0300437386506703 |
| GO:0052126 | movement in host environment | 0.0300437386506703 |
| GO:0051828 | entry into other organism during symbiotic interaction | 0.0300437386506703 |
| GO:0051806 | entry into cell of other organism during symbiotic interaction | 0.0300437386506703 |
| GO:0007004 | telomere maintenance via telomerase | 0.0441734036898593 |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 0.0441734036898593 |
| GO:0030165 | PDZ domain binding | 0.0495802336358574 |
| GO:0005626 | insoluble fraction | 0.0495802336358574 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| lymphocyte | 3.79e-17 | 53 |
| common lymphoid progenitor | 3.79e-17 | 53 |
| lymphoid lineage restricted progenitor cell | 1.58e-16 | 52 |
| lymphocyte of B lineage | 1.74e-16 | 24 |
| pro-B cell | 1.74e-16 | 24 |
| hematopoietic cell | 1.11e-12 | 182 |
| hematopoietic stem cell | 1.11e-12 | 172 |
| angioblastic mesenchymal cell | 1.11e-12 | 172 |
| B cell | 1.01e-10 | 14 |
| hematopoietic oligopotent progenitor cell | 1.88e-10 | 165 |
| hematopoietic multipotent progenitor cell | 1.88e-10 | 165 |
| leukocyte | 9.08e-10 | 140 |
| nongranular leukocyte | 3.08e-08 | 119 |
| hematopoietic lineage restricted progenitor cell | 2.60e-07 | 124 |
| Ontology term | p-value | n |
|---|---|---|
| adult organism | 1.93e-35 | 115 |
| central nervous system | 4.35e-18 | 82 |
| neural tube | 3.30e-17 | 57 |
| neural rod | 3.30e-17 | 57 |
| future spinal cord | 3.30e-17 | 57 |
| neural keel | 3.30e-17 | 57 |
| regional part of nervous system | 5.22e-16 | 94 |
| nervous system | 5.22e-16 | 94 |
| anterior neural tube | 2.02e-14 | 42 |
| regional part of brain | 5.32e-14 | 59 |
| regional part of forebrain | 6.00e-14 | 41 |
| forebrain | 6.00e-14 | 41 |
| future forebrain | 6.00e-14 | 41 |
| brain | 7.06e-14 | 69 |
| future brain | 7.06e-14 | 69 |
| gray matter | 1.09e-11 | 34 |
| brain grey matter | 1.09e-11 | 34 |
| telencephalon | 1.31e-11 | 34 |
| cerebral hemisphere | 2.89e-11 | 32 |
| regional part of telencephalon | 3.84e-11 | 33 |
| regional part of cerebral cortex | 1.02e-09 | 22 |
| cerebral cortex | 2.90e-09 | 25 |
| pallium | 2.90e-09 | 25 |
| neocortex | 3.32e-09 | 20 |
| neurectoderm | 2.73e-08 | 90 |
| neural plate | 9.20e-08 | 86 |
| presumptive neural plate | 9.20e-08 | 86 |
| Ontology term | p-value | n |
|---|---|---|
| hematologic cancer | 5.33e-09 | 51 |
| immune system cancer | 5.33e-09 | 51 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
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