MCL coexpression mm9:2275

Phase1 CAGE Peaks

	Short description
Mm9::chr19:7049103..7049172,+	p4@Ppp1r14b
Mm9::chr4:48598120..48598140,+	p5@Tmeff1
Mm9::chr6:122436142..122436198,-	p4@Rimklb
Mm9::chr6:122436270..122436322,-	p5@Rimklb

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004857	enzyme inhibitor activity	0.00253516577492826
GO:0004864	protein phosphatase inhibitor activity	0.0138721533729309
GO:0019212	phosphatase inhibitor activity	0.0138721533729309
GO:0019888	protein phosphatase regulator activity	0.0153256564215353
GO:0019208	phosphatase regulator activity	0.0153256564215353
GO:0004867	serine-type endopeptidase inhibitor activity	0.0367878587967453
GO:0004866	endopeptidase inhibitor activity	0.039834565154955
GO:0030414	protease inhibitor activity	0.039834565154955

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.75e-14	23
neuroblast (sensu Vertebrata)	1.75e-14	23
neuron	2.60e-14	33
neuronal stem cell	2.60e-14	33
neuroblast	2.60e-14	33
electrically signaling cell	2.60e-14	33
ectodermal cell	5.26e-12	44
neurectodermal cell	5.26e-12	44
neural cell	1.71e-11	43
electrically responsive cell	2.13e-09	39
electrically active cell	2.13e-09	39
non-terminally differentiated cell	7.24e-08	49

Uber Anatomy

Ontology term	p-value	n
neurectoderm	6.34e-23	64
neural plate	6.34e-23	64
presumptive neural plate	6.34e-23	64
central nervous system	7.96e-22	73
nervous system	1.82e-21	75
ectoderm-derived structure	2.27e-21	95
ectoderm	2.27e-21	95
presumptive ectoderm	2.27e-21	95
ecto-epithelium	4.51e-20	73
regional part of nervous system	2.55e-19	54
pre-chordal neural plate	2.95e-19	49
neural tube	1.25e-18	52
neural rod	1.25e-18	52
future spinal cord	1.25e-18	52
neural keel	1.25e-18	52
structure with developmental contribution from neural crest	6.18e-18	92
gray matter	7.01e-16	34
anterior neural tube	3.12e-15	40
regional part of brain	6.06e-15	46
brain	6.34e-15	47
future brain	6.34e-15	47
regional part of forebrain	9.62e-15	39
forebrain	9.62e-15	39
future forebrain	9.62e-15	39
brain grey matter	1.25e-12	29
regional part of telencephalon	1.25e-12	29
telencephalon	1.25e-12	29
cerebral cortex	2.53e-08	21
cerebral hemisphere	2.53e-08	21
pallium	2.53e-08	21

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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