Coexpression cluster:C2932

Full id: C2932_occipital_astrocytoma_gall_medial_postcentral_parietal_brain

Phase1 CAGE Peaks

Hg19::chr8:94929594..94929608,+	p21@PDP1
Hg19::chr8:94929969..94929980,+	p8@PDP1
Hg19::chr8:94930034..94930089,+	p2@PDP1
Hg19::chr8:94930100..94930120,+	p5@PDP1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
embryonic cell	1.19e-12	248
neural cell	8.33e-09	25
vascular associated smooth muscle cell	8.97e-09	32
mesodermal cell	3.05e-08	119
non-terminally differentiated cell	1.05e-07	180
smooth muscle cell	1.23e-07	42
smooth muscle myoblast	1.23e-07	42
electrically responsive cell	1.23e-07	60
electrically active cell	1.23e-07	60

Uber Anatomy

Ontology term	p-value	n
central nervous system	4.52e-31	82
regional part of nervous system	1.71e-30	94
nervous system	1.71e-30	94
brain	4.50e-27	69
future brain	4.50e-27	69
neural tube	9.03e-24	57
neural rod	9.03e-24	57
future spinal cord	9.03e-24	57
neural keel	9.03e-24	57
regional part of brain	1.78e-23	59
neural plate	4.68e-23	86
presumptive neural plate	4.68e-23	86
anatomical conduit	7.60e-23	241
head	2.08e-22	123
tube	6.64e-22	194
ectoderm-derived structure	1.04e-21	169
neurectoderm	1.20e-21	90
regional part of forebrain	5.80e-21	41
forebrain	5.80e-21	41
future forebrain	5.80e-21	41
ectoderm	6.16e-21	173
presumptive ectoderm	6.16e-21	173
anterior region of body	1.09e-20	129
craniocervical region	1.09e-20	129
epithelium	1.58e-20	309
cell layer	1.62e-20	312
anterior neural tube	1.01e-19	42
telencephalon	1.04e-19	34
cerebral hemisphere	1.41e-19	32
gray matter	2.06e-19	34
brain grey matter	2.06e-19	34
anatomical cluster	2.43e-19	286
regional part of telencephalon	4.92e-19	33
pre-chordal neural plate	1.47e-17	61
cerebral cortex	5.41e-16	25
pallium	5.41e-16	25
organism subdivision	6.66e-15	365
anatomical system	1.38e-14	625
anatomical group	1.92e-14	626
regional part of cerebral cortex	3.27e-14	22
neocortex	3.36e-13	20
multi-cellular organism	5.00e-13	659
vasculature	9.80e-13	79
vascular system	9.80e-13	79
artery	9.94e-13	42
arterial blood vessel	9.94e-13	42
arterial system	9.94e-13	42
embryo	2.06e-12	612
blood vessel	2.79e-11	60
epithelial tube open at both ends	2.79e-11	60
blood vasculature	2.79e-11	60
vascular cord	2.79e-11	60
germ layer	2.89e-11	604
embryonic tissue	2.89e-11	604
presumptive structure	2.89e-11	604
epiblast (generic)	2.89e-11	604
embryonic structure	3.30e-11	605
developing anatomical structure	3.30e-11	605
vessel	3.30e-11	69
systemic artery	9.83e-11	33
systemic arterial system	9.83e-11	33
multi-tissue structure	1.75e-10	347
splanchnic layer of lateral plate mesoderm	5.85e-09	84
circulatory system	4.64e-08	113
cardiovascular system	8.07e-08	110
aorta	1.93e-07	21
aortic system	1.93e-07	21

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0323506920625073
TCF7L2#6934	3	8.07763242235301	0.00297838168583462	0.0158736071079241

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.