Coexpression cluster:C2566

Full id: C2566_Lens_gall_papillotubular_anaplastic_Ciliary_osteoclastoma_alveolar

Phase1 CAGE Peaks

Hg19::chr1:218518669..218518689,+	p1@TGFB2
Hg19::chr1:218518858..218518869,+	p21@TGFB2
Hg19::chr1:218518942..218518953,+	p28@TGFB2
Hg19::chr1:218519057..218519070,+	p11@TGFB2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
anatomical cluster	3.12e-24	373
cell layer	1.17e-20	309
anatomical conduit	3.70e-20	240
epithelium	2.68e-19	306
tube	2.37e-18	192
multi-tissue structure	9.08e-18	342
structure with developmental contribution from neural crest	9.19e-18	132
brain	1.59e-17	68
future brain	1.59e-17	68
central nervous system	2.45e-17	81
neural plate	5.88e-17	82
presumptive neural plate	5.88e-17	82
neurectoderm	1.50e-16	86
nervous system	2.00e-15	89
ectoderm-derived structure	1.46e-14	171
ectoderm	1.46e-14	171
presumptive ectoderm	1.46e-14	171
ecto-epithelium	2.57e-14	104
neural tube	6.28e-14	56
neural rod	6.28e-14	56
future spinal cord	6.28e-14	56
neural keel	6.28e-14	56
regional part of nervous system	2.56e-13	53
regional part of brain	2.56e-13	53
pre-chordal neural plate	8.63e-12	61
organ system subdivision	2.55e-11	223
regional part of forebrain	2.18e-10	41
forebrain	2.18e-10	41
anterior neural tube	2.18e-10	41
future forebrain	2.18e-10	41
brain grey matter	7.51e-10	34
gray matter	7.51e-10	34
telencephalon	7.73e-10	34
cerebral hemisphere	2.61e-09	32
embryo	2.68e-09	592
regional part of telencephalon	3.71e-09	32
multi-cellular organism	9.35e-09	656
vasculature of organ	2.46e-08	11
epithelial tube	3.76e-08	117
anatomical system	4.86e-08	624
anatomical group	6.32e-08	625
developing anatomical structure	7.23e-08	581
embryonic structure	8.45e-08	564
vasculature	2.60e-07	78
vascular system	2.60e-07	78
germ layer	3.02e-07	560
germ layer / neural crest	3.02e-07	560
embryonic tissue	3.02e-07	560
presumptive structure	3.02e-07	560
germ layer / neural crest derived structure	3.02e-07	560
epiblast (generic)	3.02e-07	560
cerebral cortex	4.82e-07	25
pallium	4.82e-07	25
organ part	9.47e-07	218

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CEBPB#1051	3	5.97836071936861	0.00715383248472697	0.0297309634250856
CTBP2#1488	4	62.7170003393281	6.45042639894877e-08	3.96047079764733e-06
CTCF#10664	4	5.36025637307503	0.00121114538164362	0.0081770516848845
E2F6#1876	4	5.01715573169739	0.0015780219347306	0.00997379767860863
GATA2#2624	4	12.744931733554	3.78864877853583e-05	0.000722312321616473
GATA3#2625	4	27.236516357206	1.81561517799785e-06	6.77702049946094e-05
MAX#4149	3	4.83941663175534	0.0131573713783684	0.0466269454509658
TAL1#6886	4	29.8686166774402	1.25525650806991e-06	5.04222055562743e-05
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0244431463808335
USF1#7391	3	4.77112445790597	0.0137046588718802	0.0483090612906808
USF2#7392	3	9.7441480388022	0.00171834184841007	0.0107218248480165
ZNF263#10127	4	8.22184163701068	0.000218787118095832	0.00249072463776004

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.