MCL coexpression mm9:2665: Difference between revisions
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{{MCL_coexpression_mm9| | 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activated inward rectifier potassium channel activity;0.0136734947147237;16524!GO:0005432;calcium:sodium antiporter activity;0.0136734947147237;110891!GO:0015368;calcium:cation antiporter activity;0.0136734947147237;110891!GO:0030001;metal ion transport;0.0136734947147237;110891,16524!GO:0008324;cation transmembrane transporter activity;0.0136734947147237;110891,16524!GO:0006812;cation transport;0.0136734947147237;110891,16524!GO:0006810;transport;0.0136734947147237;74309,110891,16524!GO:0015491;cation:cation antiporter activity;0.0136734947147237;110891!GO:0051234;establishment of localization;0.0136734947147237;74309,110891,16524!GO:0005242;inward rectifier potassium channel activity;0.0137961185645107;16524!GO:0051179;localization;0.0147758858641532;74309,110891,16524!GO:0015298;solute:cation antiporter activity;0.0147758858641532;110891!GO:0015075;ion transmembrane transporter activity;0.0147758858641532;110891,16524!GO:0015300;solute:solute antiporter activity;0.0147758858641532;110891!GO:0006811;ion transport;0.0167436859806347;110891,16524!GO:0022891;substrate-specific transmembrane transporter activity;0.0167436859806347;110891,16524!GO:0005887;integral to plasma membrane;0.018698688541823;110891,16524!GO:0031226;intrinsic to plasma membrane;0.018698688541823;110891,16524!GO:0022857;transmembrane transporter activity;0.018698688541823;110891,16524!GO:0015297;antiporter activity;0.018698688541823;110891!GO:0022892;substrate-specific transporter activity;0.0203986913227776;110891,16524!GO:0006869;lipid transport;0.033037647344639;74309!GO:0005249;voltage-gated potassium channel activity;0.0354271221175463;16524!GO:0006816;calcium ion transport;0.0404093888106348;110891!GO:0005516;calmodulin binding;0.0404093888106348;110891!GO:0030955;potassium ion binding;0.0404093888106348;16524!GO:0044459;plasma membrane part;0.0404093888106348;110891,16524!GO:0022843;voltage-gated cation channel activity;0.0405974668135945;16524!GO:0005267;potassium channel activity;0.0412114347041476;16524!GO:0015674;di-, tri-valent inorganic cation transport;0.0434034188796974;110891!GO:0008202;steroid metabolic process;0.0441970131025135;74309!GO:0006813;potassium ion transport;0.0467582099443818;16524!GO:0005244;voltage-gated ion channel activity;0.0479976399891441;16524!GO:0022832;voltage-gated channel activity;0.0479976399891441;16524!GO:0015291;secondary active transmembrane transporter activity;0.0480191429561284;110891!GO:0031420;alkali metal ion binding;0.0480191429561284;16524!GO:0005886;plasma membrane;0.0486374730126832;110891,16524!|ontology_enrichment_celltype=CL:0000117!2.56e-09!23;CL:0000337!2.56e-09!23;CL:0000540!9.53e-09!33;CL:0000047!9.53e-09!33;CL:0000031!9.53e-09!33;CL:0000404!9.53e-09!33;CL:0000221!2.20e-07!44;CL:0000133!2.20e-07!44;CL:0002319!2.67e-07!43|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0001017!6.95e-23!73;UBERON:0001016!1.00e-21!75;UBERON:0000073!1.68e-21!54;UBERON:0010314!5.16e-21!92;UBERON:0004121!9.04e-21!95;UBERON:0000924!9.04e-21!95;UBERON:0006601!9.04e-21!95;UBERON:0002346!9.44e-21!64;UBERON:0003075!9.44e-21!64;UBERON:0007284!9.44e-21!64;UBERON:0001049!2.65e-20!52;UBERON:0005068!2.65e-20!52;UBERON:0006241!2.65e-20!52;UBERON:0007135!2.65e-20!52;UBERON:0010371!1.07e-18!73;UBERON:0000955!1.02e-17!47;UBERON:0006238!1.02e-17!47;UBERON:0002616!4.67e-17!46;UBERON:0003056!3.10e-15!49;UBERON:0002020!5.53e-15!34;UBERON:0003080!1.91e-14!40;UBERON:0002780!6.42e-14!39;UBERON:0001890!6.42e-14!39;UBERON:0006240!6.42e-14!39;UBERON:0003528!1.78e-12!29;UBERON:0002791!1.78e-12!29;UBERON:0001893!1.78e-12!29;UBERON:0000956!1.61e-08!21;UBERON:0001869!1.61e-08!21;UBERON:0000203!1.61e-08!21;UBERON:0004111!5.36e-08!122;UBERON:0002619!5.67e-08!17;UBERON:0000468!6.79e-08!333;UBERON:0002021!8.38e-08!10;UBERON:0000411!8.38e-08!10;UBERON:0001950!8.38e-08!10;UBERON:0000025!2.13e-07!114|tfbs_overrepresentation_for_novel_motifs=0.752782,1.07244,0.722405,0.801166,0.587814,0.81763,0.919454,0.467321,0.479531,0.66329,0.870507,0.906098,0.467629,0.933025,0.608226,0,1.14208,0.578045,0.448066,0.328717,0.679146,0.756749,0.932027,0.585919,0.731217,0.963352,0.437236,0.841386,0.64294,0.380786,0.825437,1.24901,0.575271,0.411696,0.608816,1.40558,0.563758,0.902078,0.536514,0.50014,0.582863,0.831295,0.261619,0.610669,0.156582,0.788421,1.05665,0.859154,0.235354,0.646474,1.12346,0.99279,0.371606,1.3966,1.41464,0.940919,0.657156,0.891887,0.425455,0.938668,1.22795,1.00308,0.494668,1.11142,0.953187,1.15459,1.55483,1.90983,1.22303,1.7608,0.700291,0.474956,0.284975,1.44925,0.416814,1.83166,1.05896,1.04436,1.20986,0.684144,0.476502,1.16055,1.00151,0.459035,1.32978,0.535545,0.195254,0.380977,1.06194,2.07346,1.62608,1.33496,1.26245,0.595071,0.531443,0.509215,0.464141,1.26539,1.05692,0.352122,0.563856,1.24872,1.37854,1.12409,1.12297,0.830796,1.18646,0.854628,0.689894,0.681267,0.744607,1.38039,0.685481,0.876299,1.63327,0.580657,1.1471,0.805461,1.14346,0.559153,1.45481,1.08896,0.965352,1.04338,1.68841,1.21376,0.928483,1.25534,1.55328,0.598722,1.36093,0.792832,1.52297,0.955954,1.65529,0.273451,0.762499,0.832891,1.60513,2.44352,2.04137,1.55966,0.978551,1.26,1.11604,0.831808,1.06002,2.40374,0.765221,0.589976,0.38417,0.260379,1.39822,0.516739,0.954936,1.48249,0.993889,0.622823,0.749933,0.762177,1.61484,1.32889,1.21423,0.741984,1.11251,2.17757,0.562367,0.904334,0.135528|tfbs_overrepresentation_jaspar=MA0003.1;0.245953,MA0004.1;0.801718,MA0006.1;1.46714,MA0007.1;0.784593,MA0009.1;1.27673,MA0014.1;0.825079,MA0017.1;0.635031,MA0019.1;1.08369,MA0024.1;1.23079,MA0025.1;1.51835,MA0027.1;2.9431,MA0028.1;0.61552,MA0029.1;1.20789,MA0030.1;1.21482,MA0031.1;1.17722,MA0038.1;0.963265,MA0040.1;1.28983,MA0041.1;0.714279,MA0042.1;0.69885,MA0043.1;1.3775,MA0046.1;1.31428,MA0048.1;0.353763,MA0050.1;0.845669,MA0051.1;0.973068,MA0052.1;2.89013,MA0055.1;0.190475,MA0056.1;0,MA0057.1;0.896032,MA0058.1;0.690848,MA0059.1;0.705317,MA0060.1;0.502699,MA0061.1;0.5406,MA0063.1;0,MA0066.1;0.951196,MA0067.1;1.63197,MA0068.1;0.343188,MA0069.1;1.29861,MA0070.1;1.28847,MA0071.1;0.844726,MA0072.1;1.2796,MA0073.1;2.11706,MA0074.1;0.911576,MA0076.1;0.657929,MA0077.1;1.2569,MA0078.1;1.0091,MA0081.1;0.732313,MA0083.1;1.37668,MA0084.1;1.96428,MA0087.1;1.33189,MA0088.1;1.40099,MA0089.1;0,MA0090.1;0.762482,MA0091.1;0.816659,MA0092.1;0.762845,MA0093.1;1.51475,MA0095.1;0,MA0098.1;0,MA0100.1;0.89873,MA0101.1;0.71579,MA0103.1;0.647985,MA0105.1;0.405648,MA0106.1;1.01755,MA0107.1;0.640607,MA0108.2;1.10817,MA0109.1;0,MA0111.1;0.778753,MA0113.1;0.986839,MA0114.1;0.537669,MA0115.1;1.38041,MA0116.1;0.602598,MA0117.1;1.34691,MA0119.1;0.716476,MA0122.1;1.36752,MA0124.1;1.57762,MA0125.1;1.5017,MA0130.1;0,MA0131.1;1.07881,MA0132.1;0,MA0133.1;0,MA0135.1;1.4152,MA0136.1;0.933582,MA0139.1;1.16863,MA0140.1;0.898603,MA0141.1;0.671467,MA0142.1;1.16183,MA0143.1;1.00467,MA0144.1;0.541532,MA0145.1;0.292366,MA0146.1;1.44443,MA0147.1;0.556853,MA0148.1;0.820161,MA0149.1;0.722227,MA0062.2;0.412742,MA0035.2;0.903829,MA0039.2;3.25387,MA0138.2;1.07027,MA0002.2;0.466067,MA0137.2;0.668025,MA0104.2;0.48458,MA0047.2;0.962424,MA0112.2;0.29236,MA0065.2;0.292912,MA0150.1;0.784464,MA0151.1;0,MA0152.1;0.962542,MA0153.1;1.43238,MA0154.1;0.35067,MA0155.1;0.312898,MA0156.1;0.656895,MA0157.1;1.12772,MA0158.1;0,MA0159.1;0.569393,MA0160.1;0.823568,MA0161.1;0,MA0162.1;0.499274,MA0163.1;0.157796,MA0164.1;0.933981,MA0080.2;0.64167,MA0018.2;0.944669,MA0099.2;1.06348,MA0079.2;0.890297,MA0102.2;2.01714,MA0258.1;0.520639,MA0259.1;0.543506,MA0442.1;0}} | ||
Latest revision as of 18:53, 17 September 2013
Phase1 CAGE Peaks
| Short description | |
|---|---|
| Mm9::chr11:3763898..3763913,- | p2@Osbp2 |
| Mm9::chr1:174259448..174259457,- | p2@Kcnj9 |
| Mm9::chr7:16715105..16715194,+ | p2@Slc8a2 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0015467 | G-protein activated inward rectifier potassium channel activity | 0.0136734947147237 |
| GO:0005432 | calcium:sodium antiporter activity | 0.0136734947147237 |
| GO:0015368 | calcium:cation antiporter activity | 0.0136734947147237 |
| GO:0030001 | metal ion transport | 0.0136734947147237 |
| GO:0008324 | cation transmembrane transporter activity | 0.0136734947147237 |
| GO:0006812 | cation transport | 0.0136734947147237 |
| GO:0006810 | transport | 0.0136734947147237 |
| GO:0015491 | cation:cation antiporter activity | 0.0136734947147237 |
| GO:0051234 | establishment of localization | 0.0136734947147237 |
| GO:0005242 | inward rectifier potassium channel activity | 0.0137961185645107 |
| GO:0051179 | localization | 0.0147758858641532 |
| GO:0015298 | solute:cation antiporter activity | 0.0147758858641532 |
| GO:0015075 | ion transmembrane transporter activity | 0.0147758858641532 |
| GO:0015300 | solute:solute antiporter activity | 0.0147758858641532 |
| GO:0006811 | ion transport | 0.0167436859806347 |
| GO:0022891 | substrate-specific transmembrane transporter activity | 0.0167436859806347 |
| GO:0005887 | integral to plasma membrane | 0.018698688541823 |
| GO:0031226 | intrinsic to plasma membrane | 0.018698688541823 |
| GO:0022857 | transmembrane transporter activity | 0.018698688541823 |
| GO:0015297 | antiporter activity | 0.018698688541823 |
| GO:0022892 | substrate-specific transporter activity | 0.0203986913227776 |
| GO:0006869 | lipid transport | 0.033037647344639 |
| GO:0005249 | voltage-gated potassium channel activity | 0.0354271221175463 |
| GO:0006816 | calcium ion transport | 0.0404093888106348 |
| GO:0005516 | calmodulin binding | 0.0404093888106348 |
| GO:0030955 | potassium ion binding | 0.0404093888106348 |
| GO:0044459 | plasma membrane part | 0.0404093888106348 |
| GO:0022843 | voltage-gated cation channel activity | 0.0405974668135945 |
| GO:0005267 | potassium channel activity | 0.0412114347041476 |
| GO:0015674 | di-, tri-valent inorganic cation transport | 0.0434034188796974 |
| GO:0008202 | steroid metabolic process | 0.0441970131025135 |
| GO:0006813 | potassium ion transport | 0.0467582099443818 |
| GO:0005244 | voltage-gated ion channel activity | 0.0479976399891441 |
| GO:0022832 | voltage-gated channel activity | 0.0479976399891441 |
| GO:0015291 | secondary active transmembrane transporter activity | 0.0480191429561284 |
| GO:0031420 | alkali metal ion binding | 0.0480191429561284 |
| GO:0005886 | plasma membrane | 0.0486374730126832 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| CNS neuron (sensu Vertebrata) | 2.56e-09 | 23 |
| neuroblast (sensu Vertebrata) | 2.56e-09 | 23 |
| neuron | 9.53e-09 | 33 |
| neuronal stem cell | 9.53e-09 | 33 |
| neuroblast | 9.53e-09 | 33 |
| electrically signaling cell | 9.53e-09 | 33 |
| ectodermal cell | 2.20e-07 | 44 |
| neurectodermal cell | 2.20e-07 | 44 |
| neural cell | 2.67e-07 | 43 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.245953 |
| MA0004.1 | 0.801718 |
| MA0006.1 | 1.46714 |
| MA0007.1 | 0.784593 |
| MA0009.1 | 1.27673 |
| MA0014.1 | 0.825079 |
| MA0017.1 | 0.635031 |
| MA0019.1 | 1.08369 |
| MA0024.1 | 1.23079 |
| MA0025.1 | 1.51835 |
| MA0027.1 | 2.9431 |
| MA0028.1 | 0.61552 |
| MA0029.1 | 1.20789 |
| MA0030.1 | 1.21482 |
| MA0031.1 | 1.17722 |
| MA0038.1 | 0.963265 |
| MA0040.1 | 1.28983 |
| MA0041.1 | 0.714279 |
| MA0042.1 | 0.69885 |
| MA0043.1 | 1.3775 |
| MA0046.1 | 1.31428 |
| MA0048.1 | 0.353763 |
| MA0050.1 | 0.845669 |
| MA0051.1 | 0.973068 |
| MA0052.1 | 2.89013 |
| MA0055.1 | 0.190475 |
| MA0056.1 | 0 |
| MA0057.1 | 0.896032 |
| MA0058.1 | 0.690848 |
| MA0059.1 | 0.705317 |
| MA0060.1 | 0.502699 |
| MA0061.1 | 0.5406 |
| MA0063.1 | 0 |
| MA0066.1 | 0.951196 |
| MA0067.1 | 1.63197 |
| MA0068.1 | 0.343188 |
| MA0069.1 | 1.29861 |
| MA0070.1 | 1.28847 |
| MA0071.1 | 0.844726 |
| MA0072.1 | 1.2796 |
| MA0073.1 | 2.11706 |
| MA0074.1 | 0.911576 |
| MA0076.1 | 0.657929 |
| MA0077.1 | 1.2569 |
| MA0078.1 | 1.0091 |
| MA0081.1 | 0.732313 |
| MA0083.1 | 1.37668 |
| MA0084.1 | 1.96428 |
| MA0087.1 | 1.33189 |
| MA0088.1 | 1.40099 |
| MA0089.1 | 0 |
| MA0090.1 | 0.762482 |
| MA0091.1 | 0.816659 |
| MA0092.1 | 0.762845 |
| MA0093.1 | 1.51475 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.89873 |
| MA0101.1 | 0.71579 |
| MA0103.1 | 0.647985 |
| MA0105.1 | 0.405648 |
| MA0106.1 | 1.01755 |
| MA0107.1 | 0.640607 |
| MA0108.2 | 1.10817 |
| MA0109.1 | 0 |
| MA0111.1 | 0.778753 |
| MA0113.1 | 0.986839 |
| MA0114.1 | 0.537669 |
| MA0115.1 | 1.38041 |
| MA0116.1 | 0.602598 |
| MA0117.1 | 1.34691 |
| MA0119.1 | 0.716476 |
| MA0122.1 | 1.36752 |
| MA0124.1 | 1.57762 |
| MA0125.1 | 1.5017 |
| MA0130.1 | 0 |
| MA0131.1 | 1.07881 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.4152 |
| MA0136.1 | 0.933582 |
| MA0139.1 | 1.16863 |
| MA0140.1 | 0.898603 |
| MA0141.1 | 0.671467 |
| MA0142.1 | 1.16183 |
| MA0143.1 | 1.00467 |
| MA0144.1 | 0.541532 |
| MA0145.1 | 0.292366 |
| MA0146.1 | 1.44443 |
| MA0147.1 | 0.556853 |
| MA0148.1 | 0.820161 |
| MA0149.1 | 0.722227 |
| MA0062.2 | 0.412742 |
| MA0035.2 | 0.903829 |
| MA0039.2 | 3.25387 |
| MA0138.2 | 1.07027 |
| MA0002.2 | 0.466067 |
| MA0137.2 | 0.668025 |
| MA0104.2 | 0.48458 |
| MA0047.2 | 0.962424 |
| MA0112.2 | 0.29236 |
| MA0065.2 | 0.292912 |
| MA0150.1 | 0.784464 |
| MA0151.1 | 0 |
| MA0152.1 | 0.962542 |
| MA0153.1 | 1.43238 |
| MA0154.1 | 0.35067 |
| MA0155.1 | 0.312898 |
| MA0156.1 | 0.656895 |
| MA0157.1 | 1.12772 |
| MA0158.1 | 0 |
| MA0159.1 | 0.569393 |
| MA0160.1 | 0.823568 |
| MA0161.1 | 0 |
| MA0162.1 | 0.499274 |
| MA0163.1 | 0.157796 |
| MA0164.1 | 0.933981 |
| MA0080.2 | 0.64167 |
| MA0018.2 | 0.944669 |
| MA0099.2 | 1.06348 |
| MA0079.2 | 0.890297 |
| MA0102.2 | 2.01714 |
| MA0258.1 | 0.520639 |
| MA0259.1 | 0.543506 |
| MA0442.1 | 0 |
