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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=-0.156100469250149,-

Latest revision as of 12:24, 17 September 2013


Full id: C3334_cerebellum_pineal_occipital_Dendritic_parietal_medial_pituitary



Phase1 CAGE Peaks

Hg19::chr12:77158021..77158045,+p1@ZDHHC17
Hg19::chr16:2723378..2723446,-p1@ERVK13-1
Hg19::chr6:83777374..83777456,+p1@DOPEY1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0042953lipoprotein transport0.00255108298212802
GO:0019706protein-cysteine S-palmitoleyltransferase activity0.00255108298212802
GO:0019707protein-cysteine S-acyltransferase activity0.00255108298212802
GO:0016417S-acyltransferase activity0.00640284617945621
GO:0015031protein transport0.00640284617945621
GO:0016409palmitoyltransferase activity0.00640284617945621
GO:0045184establishment of protein localization0.00640284617945621
GO:0008104protein localization0.00640284617945621
GO:0033036macromolecule localization0.00640284617945621
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade0.0308358649373065
GO:0030659cytoplasmic vesicle membrane0.0308358649373065
GO:0044433cytoplasmic vesicle part0.0308358649373065
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascade0.0308358649373065
GO:0012506vesicle membrane0.0308358649373065
GO:0007249I-kappaB kinase/NF-kappaB cascade0.035388549833398
GO:0009967positive regulation of signal transduction0.036510769983116
GO:0006810transport0.0481393143616867
GO:0008415acyltransferase activity0.0481393143616867
GO:0016747transferase activity, transferring groups other than amino-acyl groups0.0481393143616867
GO:0051234establishment of localization0.0481393143616867



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism1.41e-38114
neural tube1.68e-2656
neural rod1.68e-2656
future spinal cord1.68e-2656
neural keel1.68e-2656
regional part of nervous system7.97e-2553
regional part of brain7.97e-2553
central nervous system8.66e-2481
nervous system2.20e-2389
regional part of forebrain2.23e-2341
forebrain2.23e-2341
anterior neural tube2.23e-2341
future forebrain2.23e-2341
brain1.21e-2068
future brain1.21e-2068
brain grey matter6.17e-1934
gray matter6.17e-1934
telencephalon6.79e-1934
cerebral hemisphere6.54e-1832
regional part of telencephalon6.69e-1832
neurectoderm3.34e-1586
neural plate1.47e-1482
presumptive neural plate1.47e-1482
regional part of cerebral cortex1.65e-1422
cerebral cortex7.16e-1425
pallium7.16e-1425
neocortex3.21e-1320
pre-chordal neural plate2.28e-1161
organ system subdivision1.71e-09223
ecto-epithelium3.29e-09104
ectoderm-derived structure9.45e-09171
ectoderm9.45e-09171
presumptive ectoderm9.45e-09171
basal ganglion7.95e-079
nuclear complex of neuraxis7.95e-079
aggregate regional part of brain7.95e-079
collection of basal ganglia7.95e-079
cerebral subcortex7.95e-079


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.11.23283
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.211629
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.11.16674
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.24.04548
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.21.34467
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.14.34338
MA0163.13.19905
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.24.10519
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187635.017155731697390.00791769806886330.0321045334710569
EGR1#195834.988179094810140.008056488137383440.0319551693661536
SIN3A#2594235.408884726815140.006318961977991520.0275839527698832
YY1#752834.911170749853860.008441455341808260.0328397956657645



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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