MCL coexpression mm9:856

Phase1 CAGE Peaks

	Short description
Mm9::chr10:126628600..126628612,-	p@chr10:126628600..126628612 -
Mm9::chr1:173286693..173286705,+	p3@Pfdn2
Mm9::chr5:136387174..136387192,-	p@chr5:136387174..136387192 -
Mm9::chr5:136387318..136387336,-	p@chr5:136387318..136387336 -
Mm9::chr5:136387343..136387354,-	p@chr5:136387343..136387354 -
Mm9::chr5:136387416..136387428,-	p@chr5:136387416..136387428 -
Mm9::chr5:136387440..136387453,-	p@chr5:136387440..136387453 -
Mm9::chr7:31229435..31229449,-	p@chr7:31229435..31229449 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005080	protein kinase C binding	0.0207043861153407
GO:0016272	prefoldin complex	0.0207043861153407
GO:0019901	protein kinase binding	0.0444163745222791
GO:0019900	kinase binding	0.0444163745222791
GO:0019904	protein domain specific binding	0.0444163745222791
GO:0051082	unfolded protein binding	0.0444163745222791

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	2.51e-18	49
electrically responsive cell	7.96e-18	39
electrically active cell	7.96e-18	39
neural cell	9.13e-17	43
neuron	1.90e-16	33
neuronal stem cell	1.90e-16	33
neuroblast	1.90e-16	33
electrically signaling cell	1.90e-16	33
ectodermal cell	3.10e-16	44
neurectodermal cell	3.10e-16	44
CNS neuron (sensu Vertebrata)	6.94e-15	23
neuroblast (sensu Vertebrata)	6.94e-15	23
embryonic cell	3.80e-08	70

Uber Anatomy

Ontology term	p-value	n
central nervous system	5.35e-30	73
nervous system	7.49e-30	75
regional part of nervous system	7.16e-24	54
ectoderm-derived structure	1.63e-23	95
ectoderm	1.63e-23	95
presumptive ectoderm	1.63e-23	95
neural tube	3.59e-22	52
neural rod	3.59e-22	52
future spinal cord	3.59e-22	52
neural keel	3.59e-22	52
neurectoderm	1.54e-21	64
neural plate	1.54e-21	64
presumptive neural plate	1.54e-21	64
gray matter	7.66e-20	34
structure with developmental contribution from neural crest	1.45e-19	92
brain	9.94e-19	47
future brain	9.94e-19	47
regional part of brain	2.68e-18	46
anterior neural tube	7.91e-18	40
ecto-epithelium	1.40e-17	73
regional part of forebrain	2.24e-17	39
forebrain	2.24e-17	39
future forebrain	2.24e-17	39
pre-chordal neural plate	1.05e-16	49
brain grey matter	1.82e-16	29
regional part of telencephalon	1.82e-16	29
telencephalon	1.82e-16	29
cerebral cortex	8.69e-12	21
cerebral hemisphere	8.69e-12	21
pallium	8.69e-12	21
tube	4.85e-10	114
regional part of cerebral cortex	8.75e-10	17
anatomical conduit	5.60e-08	122
occipital lobe	1.92e-07	10
visual cortex	1.92e-07	10
neocortex	1.92e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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