MCL coexpression mm9:3289

Phase1 CAGE Peaks

	Short description
Mm9::chr1:9591572..9591585,+	p3@3110035E14Rik
Mm9::chr9:37240723..37240752,-	p1@Robo3
Mm9::chr9:37240831..37240835,-	p2@Robo3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001764	neuron migration	0.0377198268777735
GO:0046982	protein heterodimerization activity	0.0377198268777735
GO:0007411	axon guidance	0.0377198268777735
GO:0042803	protein homodimerization activity	0.0377198268777735
GO:0042330	taxis	0.0377198268777735
GO:0006935	chemotaxis	0.0377198268777735
GO:0007409	axonogenesis	0.0377198268777735
GO:0048667	neuron morphogenesis during differentiation	0.0377198268777735
GO:0048812	neurite morphogenesis	0.0377198268777735
GO:0042802	identical protein binding	0.0377198268777735
GO:0000904	cellular morphogenesis during differentiation	0.0377198268777735
GO:0031175	neurite development	0.0377198268777735
GO:0046983	protein dimerization activity	0.0377198268777735
GO:0007626	locomotory behavior	0.0377198268777735
GO:0048666	neuron development	0.0377198268777735
GO:0032990	cell part morphogenesis	0.0377198268777735
GO:0030030	cell projection organization and biogenesis	0.0377198268777735
GO:0048858	cell projection morphogenesis	0.0377198268777735
GO:0016477	cell migration	0.0377198268777735
GO:0030182	neuron differentiation	0.0377198268777735
GO:0007610	behavior	0.0377198268777735
GO:0048699	generation of neurons	0.0377198268777735
GO:0051674	localization of cell	0.0377198268777735
GO:0006928	cell motility	0.0377198268777735
GO:0022008	neurogenesis	0.0377757081027776
GO:0042221	response to chemical stimulus	0.0443195922446381
GO:0009605	response to external stimulus	0.0443195922446381
GO:0032989	cellular structure morphogenesis	0.0443195922446381
GO:0000902	cell morphogenesis	0.0443195922446381

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	2.41e-08	23
neuroblast (sensu Vertebrata)	2.41e-08	23

Uber Anatomy

Ontology term	p-value	n
pre-chordal neural plate	5.37e-19	49
gray matter	1.74e-17	34
neurectoderm	1.91e-17	64
neural plate	1.91e-17	64
presumptive neural plate	1.91e-17	64
brain grey matter	1.24e-16	29
regional part of telencephalon	1.24e-16	29
telencephalon	1.24e-16	29
regional part of nervous system	1.98e-15	54
anterior neural tube	4.22e-15	40
neural tube	5.80e-15	52
neural rod	5.80e-15	52
future spinal cord	5.80e-15	52
neural keel	5.80e-15	52
regional part of forebrain	3.07e-14	39
forebrain	3.07e-14	39
future forebrain	3.07e-14	39
ecto-epithelium	7.00e-14	73
occipital lobe	7.10e-14	10
visual cortex	7.10e-14	10
neocortex	7.10e-14	10
regional part of brain	3.28e-13	46
regional part of cerebral cortex	4.33e-13	17
cerebral cortex	5.49e-13	21
cerebral hemisphere	5.49e-13	21
pallium	5.49e-13	21
brain	9.45e-13	47
future brain	9.45e-13	47
central nervous system	1.16e-12	73
ectoderm-derived structure	2.25e-12	95
ectoderm	2.25e-12	95
presumptive ectoderm	2.25e-12	95
nervous system	4.87e-12	75
structure with developmental contribution from neural crest	8.67e-09	92

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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